Q9NSD9: Phenylalanine--tRNA ligase beta subunit

General Information

Protein names	- Phenylalanine--tRNA ligase beta subunit - 6.1.1.20 {ECO:0000269\|PubMed:20223217} - Phenylalanyl-tRNA synthetase beta subunit - PheRS
Gene names	FARSB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NSD9

6 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPTVSVKRDL LFQALGRTYT DEEFDELCFE FGLELDEITS EKEIISKEQG NVKAAGASDV
        70         80         90        100        110        120
VLYKIDVPAN RYDLLCLEGL VRGLQVFKER IKAPVYKRVM PDGKIQKLII TEETAKIRPF
       130        140        150        160        170        180
AVAAVLRNIK FTKDRYDSFI ELQEKLHQNI CRKRALVAIG THDLDTLSGP FTYTAKRPSD
       190        200        210        220        230        240
IKFKPLNKTK EYTACELMNI YKTDNHLKHY LHIIENKPLY PVIYDSNGVV LSMPPIINGD
       250        260        270        280        290        300
HSRITVNTRN IFIECTGTDF TKAKIVLDII VTMFSEYCEN QFTVEAAEVV FPNGKSHTFP
       310        320        330        340        350        360
ELAYRKEMVR ADLINKKVGI RETPENLAKL LTRMYLKSEV IGDGNQIEIE IPPTRADIIH
       370        380        390        400        410        420
ACDIVEDAAI AYGYNNIQMT LPKTYTIANQ FPLNKLTELL RHDMAAAGFT EALTFALCSQ
       430        440        450        460        470        480
EDIADKLGVD ISATKAVHIS NPKTAEFQVA RTTLLPGLLK TIAANRKMPL PLKLFEISDI
       490        500        510        520        530        540
VIKDSNTDVG AKNYRHLCAV YYNKNPGFEI IHGLLDRIMQ LLDVPPGEDK GGYVIKASEG
       550        560        570        580
PAFFPGRCAE IFARGQSVGK LGVLHPDVIT KFELTMPCSS LEINVGPFL

Isoforms

- Isoform 2 of Phenylalanine--tRNA ligase beta subunit

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NSD9-1-unknown	MPTVSV...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NSD9-2-unknown	PTVSVK...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9NSD9-2-unknown	PTVSVK...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9NSD9-54-	AAGASD...	54		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9NSD9-100-unknown	MPDGKI...	100	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000442950
Q9NSD9-373-	GYNNIQ...	373		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9NSD9-387-unknown	IANQFP...	387	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8103

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...PKTYTI	386	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8103
	...VGPFL	589	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	386	TYTI.\|.IANQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)