Q9NSI8: SAM domain-containing protein SAMSN-1

General Information

Protein names	- SAM domain-containing protein SAMSN-1 - Hematopoietic adaptor containing SH3 and SAM domains 1 - Nash1 - SAM domain, SH3 domain and nuclear localization signals protein 1 - SH3-SAM adaptor protein
Gene names	SAMSN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NSI8

6 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of SAM domain-containing protein SAMSN-1 - Isoform 3 of SAM domain-containing protein SAMSN-1

Sequence View

        10         20         30         40         50         60
MLKRKPSNVS EKEKHQKPKR SSSFGNFDRF RNNSLSKPDD STEAHEGDPT NGSGEQSKTS
        70         80         90        100        110        120
NNGGGLGKKM RAISWTMKKK VGKKYIKALS EEKDEEDGEN AHPYRNSDPV IGTHTEKVSL
       130        140        150        160        170        180
KASDSMDSLY SGQSSSSGIT SCSDGTSNRD SFRLDDDGPY SGPFCGRARV HTDFTPSPYD
       190        200        210        220        230        240
TDSLKIKKGD IIDIICKTPM GMWTGMLNNK VGNFKFIYVD VISEEEAAPK KIKANRRSNS
       250        260        270        280        290        300
KKSKTLQEFL ERIHLQEYTS TLLLNGYETL EDLKDIKESH LIELNIENPD DRRRLLSAAE
       310        320        330        340        350        360
NFLEEEIIQE QENEPEPLSL SSDISLNKSQ LDDCPRDSGC YISSGNSDNG KEDLESENLS
       370
DMVHKIIITE PSD         10         20         30         40         50         60
MLKRKPSNVS EKEKHQKPKR SSSFGNFDRF RNNSLSKPDD STEAHEGDPT NGSGEQSKTS
        70         80         90        100        110        120
NNGGGLGKKM RAISWTMKKK VGKKYIKALS EEKDEEDGEN AHPYRNSDPV IGTHTEKVSL
       130        140        150        160        170        180
KASDSMDSLY SGQSSSSGIT SCSDGTSNRD SFRLDDDGPY SGPFCGRARV HTDFTPSPYD
       190        200        210        220        230        240
TDSLKIKKGD IIDIICKTPM GMWTGMLNNK VGNFKFIYVD VISEEEAAPK KIKANRRSNS
       250        260        270        280        290        300
KKSKTLQEFL ERIHLQEYTS TLLLNGYETL EDLKDIKESH LIELNIENPD DRRRLLSAAE
       310        320        330        340        350        360
NFLEEEIIQE QENEPEPLSL SSDISLNKSQ LDDCPRDSGC YISSGNSDNG KEDLESENLS
       370
DMVHKIIITE PSD

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NSI8-1-unknown	MLKRKP...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NSI8-121-unknown	KASDSM...	121	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15036
Q9NSI8-121-unknown	KASDSM...	121	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146222
Q9NSI8-123-unknown	SDSMDS...	123	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15038
Q9NSI8-123-unknown	SDSMDS...	123	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146292
Q9NSI8-145-unknown	GTSNRD...	145	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178461
Q9NSI8-145-	GTSNRD...	145		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9NSI8-319-unknown	SLSSDI...	319	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15040
Q9NSI8-319-unknown	SLSSDI...	319	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144795
Q9NSI8-319-unknown	SLSSDI...	319	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151786

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EKVSLK	120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15036
...EKVSLK	120	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129526
...VSLKAS	122	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15038
...VSLKAS	122	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129596
...EPEPLS	318	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15040
...EPEPLS	318	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128070
...EPEPLS	318	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135190
...TEPSD	373	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TEPSD	373	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84491
...TEPSD	373	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84492

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	120	VSLK.\|.KASD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	122	LKAS.\|.SDSM	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	318	EPLS.\|.SLSS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)