Q9NWZ3: Interleukin-1 receptor-associated kinase 4

General Information

Protein names	- Interleukin-1 receptor-associated kinase 4 - IRAK-4 - 2.7.11.1 - Renal carcinoma antigen NY-REN-64
Gene names	IRAK4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NWZ3

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MNKPITPSTY VRCLNVGLIR KLSDFIDPQE GWKKLAVAIK KPSGDDRYNQ FHIRRFEALL
        70         80         90        100        110        120
QTGKSPTSEL LFDWGTTNCT VGDLVDLLIQ NEFFAPASLL LPDAVPKTAN TLPSKEAITV
       130        140        150        160        170        180
QQKQMPFCDK DRTLMTPVQN LEQSYMPPDS SSPENKSLEV SDTRFHSFSF YELKNVTNNF
       190        200        210        220        230        240
DERPISVGGN KMGEGGFGVV YKGYVNNTTV AVKKLAAMVD ITTEELKQQF DQEIKVMAKC
       250        260        270        280        290        300
QHENLVELLG FSSDGDDLCL VYVYMPNGSL LDRLSCLDGT PPLSWHMRCK IAQGAANGIN
       310        320        330        340        350        360
FLHENHHIHR DIKSANILLD EAFTAKISDF GLARASEKFA QTVMTSRIVG TTAYMAPEAL
       370        380        390        400        410        420
RGEITPKSDI YSFGVVLLEI ITGLPAVDEH REPQLLLDIK EEIEDEEKTI EDYIDKKMND
       430        440        450        460
ADSTSVEAMY SVASQCLHEK KNKRPDIKKV QQLLQEMTAS

Isoforms

- Isoform 2 of Interleukin-1 receptor-associated kinase 4

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NWZ3-1-Acetylation	MNKPIT...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NWZ3-1-Acetylation	MNKPIT...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9NWZ3-1-Acetylation	MNKPIT...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q9NWZ3-125-unknown	MPFCDK...	125		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt78069

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...EMTAS	460	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...EMTAS	460	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt73687

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)