Q9NXH9: tRNA (guanine(26)-N(2))-dimethyltransferase

General Information

Protein names	- tRNA (guanine(26)-N(2))-dimethyltransferase - 2.1.1.216 - tRNA 2,2-dimethylguanosine-26 methyltransferase - tRNA(guanine-26,N(2)-N(2)) methyltransferase - tRNA(m(2,2)G26)dimethyltransferase
Gene names	TRMT1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NXH9

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQGSSLWLSL TFRSARVLSR ARFFEWQSPG LPNTAAMENG TGPYGEERPR EVQETTVTEG
        70         80         90        100        110        120
AAKIAFPSAN EVFYNPVQEF NRDLTCAVIT EFARIQLGAK GIQIKVPGEK DTQKVVVDLS
       130        140        150        160        170        180
EQEEEKVELK ESENLASGDQ PRTAAVGEIC EEGLHVLEGL AASGLRSIRF ALEVPGLRSV
       190        200        210        220        230        240
VANDASTRAV DLIRRNVQLN DVAHLVQPSQ ADARMLMYQH QRVSERFDVI DLDPYGSPAT
       250        260        270        280        290        300
FLDAAVQAVS EGGLLCVTCT DMAVLAGNSG ETCYSKYGAM ALKSRACHEM ALRIVLHSLD
       310        320        330        340        350        360
LRANCYQRFV VPLLSISADF YVRVFVRVFT GQAKVKASAS KQALVFQCVG CGAFHLQRLG
       370        380        390        400        410        420
KASGVPSGRA KFSAACGPPV TPECEHCGQR HQLGGPMWAE PIHDLDFVGR VLEAVSANPG
       430        440        450        460        470        480
RFHTSERIRG VLSVITEELP DVPLYYTLDQ LSSTIHCNTP SLLQLRSALL HADFRVSLSH
       490        500        510        520        530        540
ACKNAVKTDA PASALWDIMR CWEKECPVKR ERLSETSPAF RILSVEPRLQ ANFTIREDAN
       550        560        570        580        590        600
PSSRQRGLKR FQANPEANWG PRPRARPGGK AADEAMEERR RLLQNKRKEP PEDVAQRAAR
       610        620        630        640        650
LKTFPCKRFK EGTCQRGDQC CYSHSPPTPR VSADAAPDCP ETSNQTPPGP GAAAGPGID

Isoforms

- Isoform 2 of tRNA (guanine(26)-N(2))-dimethyltransferase

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9NXH9-1-unknown	MQGSSL...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9NXH9-1-unknown	MQGSSL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt93109
Q9NXH9-37-unknown	MENGTG...	37	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q9NXH9-37-unknown	MENGTG...	37	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195826
Q9NXH9-130-unknown	KESENL...	130	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15064
Q9NXH9-130-unknown	KESENL...	130	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143917

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EKVELK	129	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15064
...EKVELK	129	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127161
...GPGID	659	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GPGID	659	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88727

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	129	VELK.\|.KESE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)