Q9NYA1: Sphingosine kinase 1 {ECO:0000305}

General Information

Protein names	- Sphingosine kinase 1 {ECO:0000305} - SK 1 {ECO:0000303\|PubMed:23935096} - SPK 1 - 2.7.1.91 {ECO:0000269\|PubMed:10802064, ECO:0000269\|PubMed:20577214, ECO:0000269\|PubMed:23602659, ECO:0000269\|PubMed:24929359} - Acetyltransferase SPHK1 - 2.3.1.-
Gene names	SPHK1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NYA1

3 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Sphingosine kinase 1 - Isoform 3 of Sphingosine kinase 1

Sequence View

        10         20         30         40         50         60
MDPAGGPRGV LPRPCRVLVL LNPRGGKGKA LQLFRSHVQP LLAEAEISFT LMLTERRNHA
        70         80         90        100        110        120
RELVRSEELG RWDALVVMSG DGLMHEVVNG LMERPDWETA IQKPLCSLPA GSGNALAASL
       130        140        150        160        170        180
NHYAGYEQVT NEDLLTNCTL LLCRRLLSPM NLLSLHTASG LRLFSVLSLA WGFIADVDLE
       190        200        210        220        230        240
SEKYRRLGEM RFTLGTFLRL AALRTYRGRL AYLPVGRVGS KTPASPVVVQ QGPVDAHLVP
       250        260        270        280        290        300
LEEPVPSHWT VVPDEDFVLV LALLHSHLGS EMFAAPMGRC AAGVMHLFYV RAGVSRAMLL
       310        320        330        340        350        360
RLFLAMEKGR HMEYECPYLV YVPVVAFRLE PKDGKGVFAV DGELMVSEAV QGQVHPNYFW
       370        380
MVSGCVEPPP SWKPQQMPPP EEPL         10         20         30         40         50         60
MDPAGGPRGV LPRPCRVLVL LNPRGGKGKA LQLFRSHVQP LLAEAEISFT LMLTERRNHA
        70         80         90        100        110        120
RELVRSEELG RWDALVVMSG DGLMHEVVNG LMERPDWETA IQKPLCSLPA GSGNALAASL
       130        140        150        160        170        180
NHYAGYEQVT NEDLLTNCTL LLCRRLLSPM NLLSLHTASG LRLFSVLSLA WGFIADVDLE
       190        200        210        220        230        240
SEKYRRLGEM RFTLGTFLRL AALRTYRGRL AYLPVGRVGS KTPASPVVVQ QGPVDAHLVP
       250        260        270        280        290        300
LEEPVPSHWT VVPDEDFVLV LALLHSHLGS EMFAAPMGRC AAGVMHLFYV RAGVSRAMLL
       310        320        330        340        350        360
RLFLAMEKGR HMEYECPYLV YVPVVAFRLE PKDGKGVFAV DGELMVSEAV QGQVHPNYFW
       370        380
MVSGCVEPPP SWKPQQMPPP EEPL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9NYA1-1-unknown	MDPAGG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9NYA1-1-unknown	MDPAGG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt102968
Q9NYA1-123-unknown	YAGYEQ...	123	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4264
Q9NYA1-123-unknown	YAGYEQ...	123	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144188
Q9NYA1-123-unknown	YAGYEQ...	123	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146897
Q9NYA1-200-unknown	LAALRT...	200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4267
Q9NYA1-200-unknown	LAALRT...	200	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147148
Q9NYA1-200-unknown	LAALRT...	200	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149493

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ASLNHY	122	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4264
...ASLNHY	122	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127441
...ASLNHY	122	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130228
...GTFLRL	199	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4267
...GTFLRL	199	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130483
...GTFLRL	199	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132878
...PEEPL	384	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PEEPL	384	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86063
...PEEPL	384	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86062

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	122	LNHY.\|.YAGY	inferred from experiment	unknown	MEROPS	Obeid LM	Taha TA et al.:Sphingosine kinase-1 is cleaved... (C01.060)	17064696,
CATB_HUMAN	199	FLRL.\|.LAAL	inferred from experiment	unknown	MEROPS	Obeid LM	Taha TA et al.:Sphingosine kinase-1 is cleaved... (C01.060)	17064696,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)