TopFIND 4.0

Q9NZ08: Endoplasmic reticulum aminopeptidase 1

General Information

Protein names
- Endoplasmic reticulum aminopeptidase 1
- 3.4.11.-
- ARTS-1
- Adipocyte-derived leucine aminopeptidase
- A-LAP
- Aminopeptidase PILS
- Puromycin-insensitive leucyl-specific aminopeptidase
- PILS-AP
- Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
Gene names ERAP1
Organism Homo sapiens
Protease Family M01.018
Protease ID M01.018
Chromosome location
UniProt ID Q9NZ08

1

N-termini

1

C-termini

0

Cleavages

5

Substrates

Sequence

        10         20         30         40         50         60 
MVFLPLKWSL ATMSFLLSSL LALLTVSTPS WCQSTEASPK RSDGTPFPWN KIRLPEYVIP 
        70         80         90        100        110        120 
VHYDLLIHAN LTTLTFWGTT KVEITASQPT STIILHSHHL QISRATLRKG AGERLSEEPL 
       130        140        150        160        170        180 
QVLEHPRQEQ IALLAPEPLL VGLPYTVVIH YAGNLSETFH GFYKSTYRTK EGELRILAST 
       190        200        210        220        230        240 
QFEPTAARMA FPCFDEPAFK ASFSIKIRRE PRHLAISNMP LVKSVTVAEG LIEDHFDVTV 
       250        260        270        280        290        300 
KMSTYLVAFI ISDFESVSKI TKSGVKVSVY AVPDKINQAD YALDAAVTLL EFYEDYFSIP 
       310        320        330        340        350        360 
YPLPKQDLAA IPDFQSGAME NWGLTTYRES ALLFDAEKSS ASSKLGITMT VAHELAHQWF 
       370        380        390        400        410        420 
GNLVTMEWWN DLWLNEGFAK FMEFVSVSVT HPELKVGDYF FGKCFDAMEV DALNSSHPVS 
       430        440        450        460        470        480 
TPVENPAQIR EMFDDVSYDK GACILNMLRE YLSADAFKSG IVQYLQKHSY KNTKNEDLWD 
       490        500        510        520        530        540 
SMASICPTDG VKGMDGFCSR SQHSSSSSHW HQEGVDVKTM MNTWTLQKGF PLITITVRGR 
       550        560        570        580        590        600 
NVHMKQEHYM KGSDGAPDTG YLWHVPLTFI TSKSDMVHRF LLKTKTDVLI LPEEVEWIKF 
       610        620        630        640        650        660 
NVGMNGYYIV HYEDDGWDSL TGLLKGTHTA VSSNDRASLI NNAFQLVSIG KLSIEKALDL 
       670        680        690        700        710        720 
SLYLKHETEI MPVFQGLNEL IPMYKLMEKR DMNEVETQFK AFLIRLLRDL IDKQTWTDEG 
       730        740        750        760        770        780 
SVSERMLRSQ LLLLACVHNY QPCVQRAEGY FRKWKESNGN LSLPVDVTLA VFAVGAQSTE 
       790        800        810        820        830        840 
GWDFLYSKYQ FSLSSTEKSQ IEFALCRTQN KEKLQWLLDE SFKGDKIKTQ EFPQILTLIG 
       850        860        870        880        890        900 
RNPVGYPLAW QFLRKNWNKL VQKFELGSSS IAHMVMGTTN QFSTRTRLEE VKGFFSSLKE 
       910        920        930        940    
NGSQLRCVQQ TIETIEENIG WMDKNFDKIR VWLQSEKLER M

Isoforms

- Isoform 2 of Endoplasmic reticulum aminopeptidase 1

Sequence View

        10         20         30         40         50         60 
MVFLPLKWSL ATMSFLLSSL LALLTVSTPS WCQSTEASPK RSDGTPFPWN KIRLPEYVIP 
        70         80         90        100        110        120 
VHYDLLIHAN LTTLTFWGTT KVEITASQPT STIILHSHHL QISRATLRKG AGERLSEEPL 
       130        140        150        160        170        180 
QVLEHPRQEQ IALLAPEPLL VGLPYTVVIH YAGNLSETFH GFYKSTYRTK EGELRILAST 
       190        200        210        220        230        240 
QFEPTAARMA FPCFDEPAFK ASFSIKIRRE PRHLAISNMP LVKSVTVAEG LIEDHFDVTV 
       250        260        270        280        290        300 
KMSTYLVAFI ISDFESVSKI TKSGVKVSVY AVPDKINQAD YALDAAVTLL EFYEDYFSIP 
       310        320        330        340        350        360 
YPLPKQDLAA IPDFQSGAME NWGLTTYRES ALLFDAEKSS ASSKLGITMT VAHELAHQWF 
       370        380        390        400        410        420 
GNLVTMEWWN DLWLNEGFAK FMEFVSVSVT HPELKVGDYF FGKCFDAMEV DALNSSHPVS 
       430        440        450        460        470        480 
TPVENPAQIR EMFDDVSYDK GACILNMLRE YLSADAFKSG IVQYLQKHSY KNTKNEDLWD 
       490        500        510        520        530        540 
SMASICPTDG VKGMDGFCSR SQHSSSSSHW HQEGVDVKTM MNTWTLQKGF PLITITVRGR 
       550        560        570        580        590        600 
NVHMKQEHYM KGSDGAPDTG YLWHVPLTFI TSKSDMVHRF LLKTKTDVLI LPEEVEWIKF 
       610        620        630        640        650        660 
NVGMNGYYIV HYEDDGWDSL TGLLKGTHTA VSSNDRASLI NNAFQLVSIG KLSIEKALDL 
       670        680        690        700        710        720 
SLYLKHETEI MPVFQGLNEL IPMYKLMEKR DMNEVETQFK AFLIRLLRDL IDKQTWTDEG 
       730        740        750        760        770        780 
SVSERMLRSQ LLLLACVHNY QPCVQRAEGY FRKWKESNGN LSLPVDVTLA VFAVGAQSTE 
       790        800        810        820        830        840 
GWDFLYSKYQ FSLSSTEKSQ IEFALCRTQN KEKLQWLLDE SFKGDKIKTQ EFPQILTLIG 
       850        860        870        880        890        900 
RNPVGYPLAW QFLRKNWNKL VQKFELGSSS IAHMVMGTTN QFSTRTRLEE VKGFFSSLKE 
       910        920        930        940    
NGSQLRCVQQ TIETIEENIG WMDKNFDKIR VWLQSEKLER M



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 5 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9NZ08-1-unknown MVFLPL... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9NZ08-1-unknown MVFLPL... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt74086

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...KLERM 941 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates