Q9NZP8: Complement C1r subcomponent-like protein

General Information

Protein names	- Complement C1r subcomponent-like protein - C1r-LP - C1r-like protein - 3.4.21.- - C1r-like serine protease analog protein - CLSPa
Gene names	C1RL
Organism	Homo sapiens
Protease Family	S01.189
Protease ID	S01.189
Chromosome location
UniProt ID	Q9NZP8

3 N-termini

3 C-termini

0 Cleavages

1 Substrates

Sequence

        10         20         30         40         50         60
MPGPRVWGKY LWRSPHSKGC PGAMWWLLLW GVLQACPTRG SVLLAQELPQ QLTSPGYPEP
        70         80         90        100        110        120
YGKGQESSTD IKAPEGFAVR LVFQDFDLEP SQDCAGDSVT ISFVGSDPSQ FCGQQGSPLG
       130        140        150        160        170        180
RPPGQREFVS SGRSLRLTFR TQPSSENKTA HLHKGFLALY QTVAVNYSQP ISEASRGSEA
       190        200        210        220        230        240
INAPGDNPAK VQNHCQEPYY QAAAAGALTC ATPGTWKDRQ DGEEVLQCMP VCGRPVTPIA
       250        260        270        280        290        300
QNQTTLGSSR AKLGNFPWQA FTSIHGRGGG ALLGDRWILT AAHTIYPKDS VSLRKNQSVN
       310        320        330        340        350        360
VFLGHTAIDE MLKLGNHPVH RVVVHPDYRQ NESHNFSGDI ALLELQHSIP LGPNVLPVCL
       370        380        390        400        410        420
PDNETLYRSG LLGYVSGFGM EMGWLTTELK YSRLPVAPRE ACNAWLQKRQ RPEVFSDNMF
       430        440        450        460        470        480
CVGDETQRHS VCQGDSGSVY VVWDNHAHHW VATGIVSWGI GCGEGYDFYT KVLSYVDWIK

GVMNGKN

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 0 Cleavages - 1 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NZP8-36-unknown	CPTRGS...	36	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NZP8-41-	SVLLAQ...	41		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9NZP8-177-unknown	GSEAIN...	177		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MPVCGR	233	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000437398
...PVCLPD	361	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000439180
...MNGKN	487	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
HPT_HUMAN	161	VQRI.\|.ILGG	inferred from experiment	unknown	MEROPS	Fries E	Wicher KB et al.:Prohaptoglobin is proteolytical... (S01.189)	15385675,