P00738: Haptoglobin

General Information

Protein names	- Haptoglobin - Zonulin - Haptoglobin alpha chain - Haptoglobin beta chain
Gene names	HP
Organism	Homo sapiens
Protease Family
Protease ID	S01.972
Chromosome location
UniProt ID	P00738

4 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSALGAVIAL LLWGQLFAVD SGNDVTDIAD DGCPKPPEIA HGYVEHSVRY QCKNYYKLRT
        70         80         90        100        110        120
EGDGVYTLND KKQWINKAVG DKLPECEADD GCPKPPEIAH GYVEHSVRYQ CKNYYKLRTE
       130        140        150        160        170        180
GDGVYTLNNE KQWINKAVGD KLPECEAVCG KPKNPANPVQ RILGGHLDAK GSFPWQAKMV
       190        200        210        220        230        240
SHHNLTTGAT LINEQWLLTT AKNLFLNHSE NATAKDIAPT LTLYVGKKQL VEIEKVVLHP
       250        260        270        280        290        300
NYSQVDIGLI KLKQKVSVNE RVMPICLPSK DYAEVGRVGY VSGWGRNANF KFTDHLKYVM
       310        320        330        340        350        360
LPVADQDQCI RHYEGSTVPE KKTPKSPVGV QPILNEHTFC AGMSKYQEDT CYGDAGSAFA
       370        380        390        400
VHDLEEDTWY ATGILSFDKS CAVAEYGVYV KVTSIQDWVQ KTIAEN

Isoforms

- Isoform 2 of Haptoglobin

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P00738-19-unknown	VDSGND...	19	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P00738-33-	CPKPPE...	33		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P00738-162-unknown	ILGGHL...	162	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P00738-162-unknown	ILGGHL...	162	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC704
P00738-298-unknown	YVMLPV...	298		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PECEAV	147	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000462662
...ANPVQR	160	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...NPVQRI	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC704
...TVPEKK	321	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000456503
...TIAEN	406	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
C1RL_HUMAN	161	VQRI.\|.ILGG	inferred from experiment	unknown	MEROPS	Fries E	Wicher KB et al.:Prohaptoglobin is proteolytical... (S01.189)	15385675,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)