Q9P0L0: Vesicle-associated membrane protein-associated protein A

General Information

Protein names	- Vesicle-associated membrane protein-associated protein A - VAMP-A - VAMP-associated protein A - VAP-A - 33 kDa VAMP-associated protein - VAP-33
Gene names	VAPA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9P0L0

6 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASASGAMAK HEQILVLDPP TDLKFKGPFT DVVTTNLKLR NPSDRKVCFK VKTTAPRRYC
        70         80         90        100        110        120
VRPNSGIIDP GSTVTVSVML QPFDYDPNEK SKHKFMVQTI FAPPNTSDME AVWKEAKPDE
       130        140        150        160        170        180
LMDSKLRCVF EMPNENDKLN DMEPSKAVPL NASKQDGPMP KPHSVSLNDT ETRKLMEECK
       190        200        210        220        230        240
RLQGEMMKLS EENRHLRDEG LRLRKVAHSD KPGSTSTASF RDNVTSPLPS LLVVIAAIFI

GFFLGKFIL

Isoforms

- Isoform 2 of Vesicle-associated membrane protein-associated protein A

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9P0L0-1-unknown	MASASG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9P0L0-1-unknown	MASASG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt94047
Q9P0L0-151-unknown	NASKQD...	151	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15084
Q9P0L0-151-unknown	NASKQD...	151	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146478
Q9P0L0-152-unknown	ASKQDG...	152	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167635
Q9P0L0-152-	ASKQDG...	152		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9P0L0-152-	ASKQDG...	152		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9P0L0-157-	GPMPKP...	157		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9P0L0-157-unknown	GPMPKP...	157		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9P0L0-157-unknown	GPMPKP...	157		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9P0L0-157-unknown	GPMPKP...	157	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160381

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KAVPLN	150	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15084
...GKFIL	249	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GKFIL	249	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89665

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	150	VPLN.\|.NASK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)