TopFIND 4.0

Q9P0U3: Sentrin-specific protease 1

General Information

Protein names
- Sentrin-specific protease 1
- 3.4.22.- {ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:29506078}
- Sentrin/SUMO-specific protease SENP1
Gene names SENP1
Organism Homo sapiens
Protease Family C48.002
Protease ID C48.002
Chromosome location
UniProt ID Q9P0U3

2

N-termini

1

C-termini

0

Cleavages

3

Substrates

Sequence

        10         20         30         40         50         60 
MDDIADRMRM DAGEVTLVNH NSVFKTHLLP QTGFPEDQLS LSDQQILSSR QGHLDRSFTC 
        70         80         90        100        110        120 
STRSAAYNPS YYSDNPSSDS FLGSGDLRTF GQSANGQWRN STPSSSSSLQ KSRNSRSLYL 
       130        140        150        160        170        180 
ETRKTSSGLS NSFAGKSNHH CHVSAYEKSF PIKPVPSPSW SGSCRRSLLS PKKTQRRHVS 
       190        200        210        220        230        240 
TAEETVQEEE REIYRQLLQM VTGKQFTIAK PTTHFPLHLS RCLSSSKNTL KDSLFKNGNS 
       250        260        270        280        290        300 
CASQIIGSDT SSSGSASILT NQEQLSHSVY SLSSYTPDVA FGSKDSGTLH HPHHHHSVPH 
       310        320        330        340        350        360 
QPDNLAASNT QSEGSDSVIL LKVKDSQTPT PSSTFFQAEL WIKELTSVYD SRARERLRQI 
       370        380        390        400        410        420 
EEQKALALQL QNQRLQEREH SVHDSVELHL RVPLEKEIPV TVVQETQKKG HKLTDSEDEF 
       430        440        450        460        470        480 
PEITEEMEKE IKNVFRNGNQ DEVLSEAFRL TITRKDIQTL NHLNWLNDEI INFYMNMLME 
       490        500        510        520        530        540 
RSKEKGLPSV HAFNTFFFTK LKTAGYQAVK RWTKKVDVFS VDILLVPIHL GVHWCLAVVD 
       550        560        570        580        590        600 
FRKKNITYYD SMGGINNEAC RILLQYLKQE SIDKKRKEFD TNGWQLFSKK SQEIPQQMNG 
       610        620        630        640    
SDCGMFACKY ADCITKDRPI NFTQQHMPYF RKRMVWEILH RKLL

Isoforms

- Isoform 2 of Sentrin-specific protease 1

Sequence View

        10         20         30         40         50         60 
MDDIADRMRM DAGEVTLVNH NSVFKTHLLP QTGFPEDQLS LSDQQILSSR QGHLDRSFTC 
        70         80         90        100        110        120 
STRSAAYNPS YYSDNPSSDS FLGSGDLRTF GQSANGQWRN STPSSSSSLQ KSRNSRSLYL 
       130        140        150        160        170        180 
ETRKTSSGLS NSFAGKSNHH CHVSAYEKSF PIKPVPSPSW SGSCRRSLLS PKKTQRRHVS 
       190        200        210        220        230        240 
TAEETVQEEE REIYRQLLQM VTGKQFTIAK PTTHFPLHLS RCLSSSKNTL KDSLFKNGNS 
       250        260        270        280        290        300 
CASQIIGSDT SSSGSASILT NQEQLSHSVY SLSSYTPDVA FGSKDSGTLH HPHHHHSVPH 
       310        320        330        340        350        360 
QPDNLAASNT QSEGSDSVIL LKVKDSQTPT PSSTFFQAEL WIKELTSVYD SRARERLRQI 
       370        380        390        400        410        420 
EEQKALALQL QNQRLQEREH SVHDSVELHL RVPLEKEIPV TVVQETQKKG HKLTDSEDEF 
       430        440        450        460        470        480 
PEITEEMEKE IKNVFRNGNQ DEVLSEAFRL TITRKDIQTL NHLNWLNDEI INFYMNMLME 
       490        500        510        520        530        540 
RSKEKGLPSV HAFNTFFFTK LKTAGYQAVK RWTKKVDVFS VDILLVPIHL GVHWCLAVVD 
       550        560        570        580        590        600 
FRKKNITYYD SMGGINNEAC RILLQYLKQE SIDKKRKEFD TNGWQLFSKK SQEIPQQMNG 
       610        620        630        640    
SDCGMFACKY ADCITKDRPI NFTQQHMPYF RKRMVWEILH RKLL



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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 3 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...HRKLL 644 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...HRKLL 644 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt84873

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates