P46060: Ran GTPase-activating protein 1

General Information

Protein names	- Ran GTPase-activating protein 1 - RanGAP1
Gene names	RANGAP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P46060

6 N-termini

8 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASEDIAKLA ETLAKTQVAG GQLSFKGKSL KLNTAEDAKD VIKEIEDFDS LEALRLEGNT
        70         80         90        100        110        120
VGVEAARVIA KALEKKSELK RCHWSDMFTG RLRTEIPPAL ISLGEGLITA GAQLVELDLS
       130        140        150        160        170        180
DNAFGPDGVQ GFEALLKSSA CFTLQELKLN NCGMGIGGGK ILAAALTECH RKSSAQGKPL
       190        200        210        220        230        240
ALKVFVAGRN RLENDGATAL AEAFRVIGTL EEVHMPQNGI NHPGITALAQ AFAVNPLLRV
       250        260        270        280        290        300
INLNDNTFTE KGAVAMAETL KTLRQVEVIN FGDCLVRSKG AVAIADAIRG GLPKLKELNL
       310        320        330        340        350        360
SFCEIKRDAA LAVAEAMADK AELEKLDLNG NTLGEEGCEQ LQEVLEGFNM AKVLASLSDD
       370        380        390        400        410        420
EDEEEEEEGE EEEEEAEEEE EEDEEEEEEE EEEEEEEPQQ RGQGEKSATP SRKILDPNTG
       430        440        450        460        470        480
EPAPVLSSPP PADVSTFLAF PSPEKLLRLG PKSSVLIAQQ TDTSDPEKVV SAFLKVSSVF
       490        500        510        520        530        540
KDEATVRMAV QDAVDALMQK AFNSSSFNSN TFLTRLLVHM GLLKSEDKVK AIANLYGPLM
       550        560        570        580
ALNHMVQQDY FPKALAPLLL AFVTKPNSAL ESCSFARHSL LQTLYKV

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

6 N-termini - 8 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P46060-2-unknown	MASEDI...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P46060-2-Acetylation	ASEDIA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P46060-2-Acetylation	ASEDIA...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P46060-65-unknown	AARVIA...	65		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11527
P46060-219-	GINHPG...	219			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P46060-320-unknown	KAELEK...	320		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11528
P46060-525-unknown	SEDKVK...	525		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31581

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NTAEDA	37	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000404842
...TVGVEA	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11527
...IPPALI	100	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000408743
...VQGFEA	133	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000394787
...EAMADK	319	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11528
...VLASLS	357	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000393407
...MGLLKS	524	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31581
...TLYKV	587	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	64	GVEA.\|.AARV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	319	MADK.\|.KAEL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
SENP1_HUMAN	524	LLKS.\|.SEDK	inferred from experiment	unknown	MEROPS	Hay RT	Shen LN et al.:Characterization of SENP7, a SU... (C48.002)	19392659,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)