P46060: Ran GTPase-activating protein 1
Protein names | - Ran GTPase-activating protein 1 - RanGAP1 |
---|---|
Gene names | RANGAP1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P46060 |
6
N-termini
8
C-termini
3
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MASEDIAKLA ETLAKTQVAG GQLSFKGKSL KLNTAEDAKD VIKEIEDFDS LEALRLEGNT
70 80 90 100 110 120
VGVEAARVIA KALEKKSELK RCHWSDMFTG RLRTEIPPAL ISLGEGLITA GAQLVELDLS
130 140 150 160 170 180
DNAFGPDGVQ GFEALLKSSA CFTLQELKLN NCGMGIGGGK ILAAALTECH RKSSAQGKPL
190 200 210 220 230 240
ALKVFVAGRN RLENDGATAL AEAFRVIGTL EEVHMPQNGI NHPGITALAQ AFAVNPLLRV
250 260 270 280 290 300
INLNDNTFTE KGAVAMAETL KTLRQVEVIN FGDCLVRSKG AVAIADAIRG GLPKLKELNL
310 320 330 340 350 360
SFCEIKRDAA LAVAEAMADK AELEKLDLNG NTLGEEGCEQ LQEVLEGFNM AKVLASLSDD
370 380 390 400 410 420
EDEEEEEEGE EEEEEAEEEE EEDEEEEEEE EEEEEEEPQQ RGQGEKSATP SRKILDPNTG
430 440 450 460 470 480
EPAPVLSSPP PADVSTFLAF PSPEKLLRLG PKSSVLIAQQ TDTSDPEKVV SAFLKVSSVF
490 500 510 520 530 540
KDEATVRMAV QDAVDALMQK AFNSSSFNSN TFLTRLLVHM GLLKSEDKVK AIANLYGPLM
550 560 570 580
ALNHMVQQDY FPKALAPLLL AFVTKPNSAL ESCSFARHSL LQTLYKV
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
6 N-termini - 8 C-termini - 3 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P46060-2-unknown | MASEDI... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P46060-2-Acetylation | ASEDIA... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
P46060-2-Acetylation | ASEDIA... | 2 | acetylation- | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC | |||
P46060-65-unknown | AARVIA... | 65 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11527 | |||
P46060-219- | GINHPG... | 219 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P46060-320-unknown | KAELEK... | 320 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11528 | |||
P46060-525-unknown | SEDKVK... | 525 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC31581 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...NTAEDA | 37 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000404842 | |||
...TVGVEA | 64 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11527 | |||
...IPPALI | 100 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000408743 | |||
...VQGFEA | 133 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000394787 | |||
...EAMADK | 319 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11528 | |||
...VLASLS | 357 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000393407 | |||
...MGLLKS | 524 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC31581 | |||
...TLYKV | 587 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 64 | GVEA.|.AARV | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
GRAB_HUMAN | 319 | MADK.|.KAEL | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
SENP1_HUMAN | 524 | LLKS.|.SEDK | inferred from experiment | unknown | MEROPS | Hay RT | Shen LN et al.:Characterization of SENP7, a SU... (C48.002) | 19392659, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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