Q9UEW8: STE20/SPS1-related proline-alanine-rich protein kinase

General Information

Protein names	- STE20/SPS1-related proline-alanine-rich protein kinase - Ste-20-related kinase - 2.7.11.1 - DCHT - Serine/threonine-protein kinase 39
Gene names	STK39
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UEW8

4 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAEPSGSPVH VQLPQQAAPV TAAAAAAPAA ATAAPAPAAP AAPAPAPAPA AQAVGWPICR
        70         80         90        100        110        120
DAYELQEVIG SGATAVVQAA LCKPRQERVA IKRINLEKCQ TSMDELLKEI QAMSQCSHPN
       130        140        150        160        170        180
VVTYYTSFVV KDELWLVMKL LSGGSMLDII KYIVNRGEHK NGVLEEAIIA TILKEVLEGL
       190        200        210        220        230        240
DYLHRNGQIH RDLKAGNILL GEDGSVQIAD FGVSAFLATG GDVTRNKVRK TFVGTPCWMA
       250        260        270        280        290        300
PEVMEQVRGY DFKADMWSFG ITAIELATGA APYHKYPPMK VLMLTLQNDP PTLETGVEDK
       310        320        330        340        350        360
EMMKKYGKSF RKLLSLCLQK DPSKRPTAAE LLKCKFFQKA KNREYLIEKL LTRTPDIAQR
       370        380        390        400        410        420
AKKVRRVPGS SGHLHKTEDG DWEWSDDEMD EKSEEGKAAF SQEKSRRVKE ENPEIAVSAS
       430        440        450        460        470        480
TIPEQIQSLS VHDSQGPPNA NEDYREASSC AVNLVLRLRN SRKELNDIRF EFTPGRDTAD
       490        500        510        520        530        540
GVSQELFSAG LVDGHDVVIV AANLQKIVDD PKALKTLTFK LASGCDGSEI PDEVKLIGFA

QLSVS

Isoforms

- Isoform 2 of STE20/SPS1-related proline-alanine-rich protein kinase

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UEW8-1-unknown	MAEPSG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UEW8-89-unknown	VAIKRI...	89	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13512
Q9UEW8-391-unknown	EKSEEG...	391	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2340
Q9UEW8-434-	SQGPPN...	434		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9UEW8-434-	SQGPPN...	434		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PRQERV	88	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13512
...DDEMDE	390	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2340
...QLSVS	545	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	88	QERV.\|.VAIK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CASP3_HUMAN	390	EMDE.\|.EKSE	inferred from experiment	unknown	MEROPS	DeAizpurua HJ	Johnston AM et al.:SPAK, a STE20/SPS1-related kina... (C14.003)	10980603,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)