Q9UG56: Phosphatidylserine decarboxylase proenzyme, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03208}

General Information

Protein names	- Phosphatidylserine decarboxylase proenzyme, mitochondrial {ECO:0000255\|HAMAP-Rule:MF_03208} - 4.1.1.65 {ECO:0000255\|HAMAP-Rule:MF_03208} - Phosphatidylserine decarboxylase beta chain {ECO:0000255\|HAMAP-Rule:MF_03208} - Phosphatidylserine decarboxylase alpha chain {ECO:0000255\|HAMAP-Rule:MF_03208}
Gene names	PISD
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UG56

4 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Phosphatidylserine decarboxylase proenzyme - Isoform 2 of Phosphatidylserine decarboxylase proenzyme, mitochondrial

Sequence View

        10         20         30         40         50         60
MATSVGHRCL GLLHGVAPWR SSLHPCEITA LSQSLQPLRK LPFRAFRTDA RKIHTAPART
        70         80         90        100        110        120
MFLLRPLPIL LVTGGGYAGY RQYEKYRERE LEKLGLEIPP KLAGHWEVAL YKSVPTRLLS
       130        140        150        160        170        180
RAWGRLNQVE LPHWLRRPVY SLYIWTFGVN MKEAAVEDLH HYRNLSEFFR RKLKPQARPV
       190        200        210        220        230        240
CGLHSVISPS DGRILNFGQV KNCEVEQVKG VTYSLESFLG PRMCTEDLPF PPAASCDSFK
       250        260        270        280        290        300
NQLVTREGNE LYHCVIYLAP GDYHCFHSPT DWTVSHRRHF PGSLMSVNPG MARWIKELFC
       310        320        330        340        350        360
HNERVVLTGD WKHGFFSLTA VGATNVGSIR IYFDRDLHTN SPRHSKGSYN DFSFVTHTNR
       370        380        390        400
EGVPMRKGEH LGEFNLGSTI VLIFEAPKDF NFQLKTGQKI RFGEALGSL         10         20         30         40         50         60
MATSVGHRCL GLLHGVAPWR SSLHPCEITA LSQSLQPLRK LPFRAFRTDA RKIHTAPART
        70         80         90        100        110        120
MFLLRPLPIL LVTGGGYAGY RQYEKYRERE LEKLGLEIPP KLAGHWEVAL YKSVPTRLLS
       130        140        150        160        170        180
RAWGRLNQVE LPHWLRRPVY SLYIWTFGVN MKEAAVEDLH HYRNLSEFFR RKLKPQARPV
       190        200        210        220        230        240
CGLHSVISPS DGRILNFGQV KNCEVEQVKG VTYSLESFLG PRMCTEDLPF PPAASCDSFK
       250        260        270        280        290        300
NQLVTREGNE LYHCVIYLAP GDYHCFHSPT DWTVSHRRHF PGSLMSVNPG MARWIKELFC
       310        320        330        340        350        360
HNERVVLTGD WKHGFFSLTA VGATNVGSIR IYFDRDLHTN SPRHSKGSYN DFSFVTHTNR
       370        380        390        400
EGVPMRKGEH LGEFNLGSTI VLIFEAPKDF NFQLKTGQKI RFGEALGSL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UG56-1-unknown	MATSVG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UG56-155-unknown	AVEDLH...	155	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171944
Q9UG56-155-	AVEDLH...	155		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UG56-155-	AVEDLH...	155		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q9UG56-155-	AVEDLH...	155		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9UG56-378-unknown	STIVLI...	378	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UG56-378-unknown	STIVLI...	378	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt116182

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LAPGDY	262	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000412169
...EFNLGS	377	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EFNLGS	377	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92588
...ALGSL	409	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ALGSL	409	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80875

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)