Q9UI10: Translation initiation factor eIF-2B subunit delta

General Information

Protein names	- Translation initiation factor eIF-2B subunit delta - eIF-2B GDP-GTP exchange factor subunit delta
Gene names	EIF2B4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UI10

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Translation initiation factor eIF-2B subunit delta - Isoform 3 of Translation initiation factor eIF-2B subunit delta

Sequence View

        10         20         30         40         50         60
MAAVAVAVRE DSGSGMKAEL PPGPGAVGRE MTKEEKLQLR KEKKQQKKKR KEEKGAEPET
        70         80         90        100        110        120
GSAVSAAQCQ VGPTRELPES GIQLGTPREK VPAGRSKAEL RAERRAKQEA ERALKQARKG
       130        140        150        160        170        180
EQGGPPPKAS PSTAGETPSG VKRLPEYPQV DDLLLRRLVK KPERQQVPTR KDYGSKVSLF
       190        200        210        220        230        240
SHLPQYSRQN SLTQFMSIPS SVIHPAMVRL GLQYSQGLVS GSNARCIALL RALQQVIQDY
       250        260        270        280        290        300
TTPPNEELSR DLVNKLKPYM SFLTQCRPLS ASMHNAIKFL NKEITSVGSS KREEEAKSEL
       310        320        330        340        350        360
RAAIDRYVQE KIVLAAQAIS RFAYQKISNG DVILVYGCSS LVSRILQEAW TEGRRFRVVV
       370        380        390        400        410        420
VDSRPWLEGR HTLRSLVHAG VPASYLLIPA ASYVLPEVSK VLLGAHALLA NGSVMSRVGT
       430        440        450        460        470        480
AQLALVARAH NVPVLVCCET YKFCERVQTD AFVSNELDDP DDLQCKRGEH VALANWQNHA
       490        500        510        520
SLRLLNLVYD VTPPELVDLV ITELGMIPCS SVPVVLRVKS SDQ         10         20         30         40         50         60
MAAVAVAVRE DSGSGMKAEL PPGPGAVGRE MTKEEKLQLR KEKKQQKKKR KEEKGAEPET
        70         80         90        100        110        120
GSAVSAAQCQ VGPTRELPES GIQLGTPREK VPAGRSKAEL RAERRAKQEA ERALKQARKG
       130        140        150        160        170        180
EQGGPPPKAS PSTAGETPSG VKRLPEYPQV DDLLLRRLVK KPERQQVPTR KDYGSKVSLF
       190        200        210        220        230        240
SHLPQYSRQN SLTQFMSIPS SVIHPAMVRL GLQYSQGLVS GSNARCIALL RALQQVIQDY
       250        260        270        280        290        300
TTPPNEELSR DLVNKLKPYM SFLTQCRPLS ASMHNAIKFL NKEITSVGSS KREEEAKSEL
       310        320        330        340        350        360
RAAIDRYVQE KIVLAAQAIS RFAYQKISNG DVILVYGCSS LVSRILQEAW TEGRRFRVVV
       370        380        390        400        410        420
VDSRPWLEGR HTLRSLVHAG VPASYLLIPA ASYVLPEVSK VLLGAHALLA NGSVMSRVGT
       430        440        450        460        470        480
AQLALVARAH NVPVLVCCET YKFCERVQTD AFVSNELDDP DDLQCKRGEH VALANWQNHA
       490        500        510        520
SLRLLNLVYD VTPPELVDLV ITELGMIPCS SVPVVLRVKS SDQ

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UI10-2-unknown	MAAVAV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UI10-1-unknown	MAAVAV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73756
Q9UI10-2-Acetylation	AAVAVA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UI10-2-Acetylation	AAVAVA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9UI10-2-Acetylation	AAVAVA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9UI10-2-Acetylation	AAVAVA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111087
Q9UI10-119-unknown	KGEQGG...	119		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10579
Q9UI10-119-unknown	KGEQGG...	119		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143363
Q9UI10-119-unknown	KGEQGG...	119		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144249

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LKQARK	118	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10579
...LKQARK	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126595
...LKQARK	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127504
...KSSDQ	523	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KSSDQ	523	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69374
...KSSDQ	523	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69373

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	118	QARK.\|.KGEQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)