Q9UKU0: Long-chain-fatty-acid--CoA ligase 6

General Information

Protein names	- Long-chain-fatty-acid--CoA ligase 6 - 6.2.1.3 - Long-chain acyl-CoA synthetase 6 - LACS 6
Gene names	ACSL6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UKU0

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 1 of Long-chain-fatty-acid--CoA ligase 6 - Isoform 2 of Long-chain-fatty-acid--CoA ligase 6 - Isoform 3 of Long-chain-fatty-acid--CoA ligase 6 - Isoform 5 of Long-chain-fatty-acid--CoA ligase 6 - Isoform 6 of Long-chain-fatty-acid--CoA ligase 6 - Isoform 7 of Long-chain-fatty-acid--CoA ligase 6 - Isoform 8 of Long-chain-fatty-acid--CoA ligase 6 - Isoform 9 of Long-chain-fatty-acid--CoA ligase 6

Sequence View

        10         20         30         40         50         60
MQTQEILRIL RLPELGDLGQ FFRSLSATTL VSMGALAAIL AYWFTHRPKA LQPPCNLLMQ
        70         80         90        100        110        120
SEEVEDSGGA RRSVIGSGPQ LLTHYYDDAR TMYQVFRRGL SISGNGPCLG FRKPKQPYQW
       130        140        150        160        170        180
LSYQEVADRA EFLGSGLLQH NCKACTDQFI GVFAQNRPEW IIVELACYTY SMVVVPLYDT
       190        200        210        220        230        240
LGPGAIRYII NTADISTVIV DKPQKAVLLL EHVERKETPG LKLIILMDPF EEALKERGQK
       250        260        270        280        290        300
CGVVIKSMQA VEDCGQENHQ APVPPQPDDL SIVCFTSGTT GNPKGAMLTH GNVVADFSGF
       310        320        330        340        350        360
LKVTEKVIFP RQDDVLISFL PLAHMFERVI QSVVYCHGGR VGFFQGDIRL LSDDMKALCP
       370        380        390        400        410        420
TIFPVVPRLL NRMYDKIFSQ ANTPLKRWLL EFAAKRKQAE VRSGIIRNDS IWDELFFNKI
       430        440        450        460        470        480
QASLGGCVRM IVTGAAPASP TVLGFLRAAL GCQVYEGYGQ TECTAGCTFT TPGDWTSGHV
       490        500        510        520        530        540
GAPLPCNHIK LVDVEELNYW ACKGEGEICV RGPNVFKGYL KDPDRTKEAL DSDGWLHTGD
       550        560        570        580        590        600
IGKWLPAGTL KIIDRKKHIF KLAQGEYVAP EKIENIYIRS QPVAQIYVHG DSLKAFLVGI
       610        620        630        640        650        660
VVPDPEVMPS WAQKRGIEGT YADLCTNKDL KKAILEDMVR LGKESGLHSF EQVKAIHIHS
       670        680        690
DMFSVQNGLL TPTLKAKRPE LREYFKKQIE ELYSISM         10         20         30         40         50         60
MQTQEILRIL RLPELGDLGQ FFRSLSATTL VSMGALAAIL AYWFTHRPKA LQPPCNLLMQ
        70         80         90        100        110        120
SEEVEDSGGA RRSVIGSGPQ LLTHYYDDAR TMYQVFRRGL SISGNGPCLG FRKPKQPYQW
       130        140        150        160        170        180
LSYQEVADRA EFLGSGLLQH NCKACTDQFI GVFAQNRPEW IIVELACYTY SMVVVPLYDT
       190        200        210        220        230        240
LGPGAIRYII NTADISTVIV DKPQKAVLLL EHVERKETPG LKLIILMDPF EEALKERGQK
       250        260        270        280        290        300
CGVVIKSMQA VEDCGQENHQ APVPPQPDDL SIVCFTSGTT GNPKGAMLTH GNVVADFSGF
       310        320        330        340        350        360
LKVTEKVIFP RQDDVLISFL PLAHMFERVI QSVVYCHGGR VGFFQGDIRL LSDDMKALCP
       370        380        390        400        410        420
TIFPVVPRLL NRMYDKIFSQ ANTPLKRWLL EFAAKRKQAE VRSGIIRNDS IWDELFFNKI
       430        440        450        460        470        480
QASLGGCVRM IVTGAAPASP TVLGFLRAAL GCQVYEGYGQ TECTAGCTFT TPGDWTSGHV
       490        500        510        520        530        540
GAPLPCNHIK LVDVEELNYW ACKGEGEICV RGPNVFKGYL KDPDRTKEAL DSDGWLHTGD
       550        560        570        580        590        600
IGKWLPAGTL KIIDRKKHIF KLAQGEYVAP EKIENIYIRS QPVAQIYVHG DSLKAFLVGI
       610        620        630        640        650        660
VVPDPEVMPS WAQKRGIEGT YADLCTNKDL KKAILEDMVR LGKESGLHSF EQVKAIHIHS
       670        680        690
DMFSVQNGLL TPTLKAKRPE LREYFKKQIE ELYSISM         10         20         30         40         50         60
MQTQEILRIL RLPELGDLGQ FFRSLSATTL VSMGALAAIL AYWFTHRPKA LQPPCNLLMQ
        70         80         90        100        110        120
SEEVEDSGGA RRSVIGSGPQ LLTHYYDDAR TMYQVFRRGL SISGNGPCLG FRKPKQPYQW
       130        140        150        160        170        180
LSYQEVADRA EFLGSGLLQH NCKACTDQFI GVFAQNRPEW IIVELACYTY SMVVVPLYDT
       190        200        210        220        230        240
LGPGAIRYII NTADISTVIV DKPQKAVLLL EHVERKETPG LKLIILMDPF EEALKERGQK
       250        260        270        280        290        300
CGVVIKSMQA VEDCGQENHQ APVPPQPDDL SIVCFTSGTT GNPKGAMLTH GNVVADFSGF
       310        320        330        340        350        360
LKVTEKVIFP RQDDVLISFL PLAHMFERVI QSVVYCHGGR VGFFQGDIRL LSDDMKALCP
       370        380        390        400        410        420
TIFPVVPRLL NRMYDKIFSQ ANTPLKRWLL EFAAKRKQAE VRSGIIRNDS IWDELFFNKI
       430        440        450        460        470        480
QASLGGCVRM IVTGAAPASP TVLGFLRAAL GCQVYEGYGQ TECTAGCTFT TPGDWTSGHV
       490        500        510        520        530        540
GAPLPCNHIK LVDVEELNYW ACKGEGEICV RGPNVFKGYL KDPDRTKEAL DSDGWLHTGD
       550        560        570        580        590        600
IGKWLPAGTL KIIDRKKHIF KLAQGEYVAP EKIENIYIRS QPVAQIYVHG DSLKAFLVGI
       610        620        630        640        650        660
VVPDPEVMPS WAQKRGIEGT YADLCTNKDL KKAILEDMVR LGKESGLHSF EQVKAIHIHS
       670        680        690
DMFSVQNGLL TPTLKAKRPE LREYFKKQIE ELYSISM         10         20         30         40         50         60
MQTQEILRIL RLPELGDLGQ FFRSLSATTL VSMGALAAIL AYWFTHRPKA LQPPCNLLMQ
        70         80         90        100        110        120
SEEVEDSGGA RRSVIGSGPQ LLTHYYDDAR TMYQVFRRGL SISGNGPCLG FRKPKQPYQW
       130        140        150        160        170        180
LSYQEVADRA EFLGSGLLQH NCKACTDQFI GVFAQNRPEW IIVELACYTY SMVVVPLYDT
       190        200        210        220        230        240
LGPGAIRYII NTADISTVIV DKPQKAVLLL EHVERKETPG LKLIILMDPF EEALKERGQK
       250        260        270        280        290        300
CGVVIKSMQA VEDCGQENHQ APVPPQPDDL SIVCFTSGTT GNPKGAMLTH GNVVADFSGF
       310        320        330        340        350        360
LKVTEKVIFP RQDDVLISFL PLAHMFERVI QSVVYCHGGR VGFFQGDIRL LSDDMKALCP
       370        380        390        400        410        420
TIFPVVPRLL NRMYDKIFSQ ANTPLKRWLL EFAAKRKQAE VRSGIIRNDS IWDELFFNKI
       430        440        450        460        470        480
QASLGGCVRM IVTGAAPASP TVLGFLRAAL GCQVYEGYGQ TECTAGCTFT TPGDWTSGHV
       490        500        510        520        530        540
GAPLPCNHIK LVDVEELNYW ACKGEGEICV RGPNVFKGYL KDPDRTKEAL DSDGWLHTGD
       550        560        570        580        590        600
IGKWLPAGTL KIIDRKKHIF KLAQGEYVAP EKIENIYIRS QPVAQIYVHG DSLKAFLVGI
       610        620        630        640        650        660
VVPDPEVMPS WAQKRGIEGT YADLCTNKDL KKAILEDMVR LGKESGLHSF EQVKAIHIHS
       670        680        690
DMFSVQNGLL TPTLKAKRPE LREYFKKQIE ELYSISM         10         20         30         40         50         60
MQTQEILRIL RLPELGDLGQ FFRSLSATTL VSMGALAAIL AYWFTHRPKA LQPPCNLLMQ
        70         80         90        100        110        120
SEEVEDSGGA RRSVIGSGPQ LLTHYYDDAR TMYQVFRRGL SISGNGPCLG FRKPKQPYQW
       130        140        150        160        170        180
LSYQEVADRA EFLGSGLLQH NCKACTDQFI GVFAQNRPEW IIVELACYTY SMVVVPLYDT
       190        200        210        220        230        240
LGPGAIRYII NTADISTVIV DKPQKAVLLL EHVERKETPG LKLIILMDPF EEALKERGQK
       250        260        270        280        290        300
CGVVIKSMQA VEDCGQENHQ APVPPQPDDL SIVCFTSGTT GNPKGAMLTH GNVVADFSGF
       310        320        330        340        350        360
LKVTEKVIFP RQDDVLISFL PLAHMFERVI QSVVYCHGGR VGFFQGDIRL LSDDMKALCP
       370        380        390        400        410        420
TIFPVVPRLL NRMYDKIFSQ ANTPLKRWLL EFAAKRKQAE VRSGIIRNDS IWDELFFNKI
       430        440        450        460        470        480
QASLGGCVRM IVTGAAPASP TVLGFLRAAL GCQVYEGYGQ TECTAGCTFT TPGDWTSGHV
       490        500        510        520        530        540
GAPLPCNHIK LVDVEELNYW ACKGEGEICV RGPNVFKGYL KDPDRTKEAL DSDGWLHTGD
       550        560        570        580        590        600
IGKWLPAGTL KIIDRKKHIF KLAQGEYVAP EKIENIYIRS QPVAQIYVHG DSLKAFLVGI
       610        620        630        640        650        660
VVPDPEVMPS WAQKRGIEGT YADLCTNKDL KKAILEDMVR LGKESGLHSF EQVKAIHIHS
       670        680        690
DMFSVQNGLL TPTLKAKRPE LREYFKKQIE ELYSISM         10         20         30         40         50         60
MQTQEILRIL RLPELGDLGQ FFRSLSATTL VSMGALAAIL AYWFTHRPKA LQPPCNLLMQ
        70         80         90        100        110        120
SEEVEDSGGA RRSVIGSGPQ LLTHYYDDAR TMYQVFRRGL SISGNGPCLG FRKPKQPYQW
       130        140        150        160        170        180
LSYQEVADRA EFLGSGLLQH NCKACTDQFI GVFAQNRPEW IIVELACYTY SMVVVPLYDT
       190        200        210        220        230        240
LGPGAIRYII NTADISTVIV DKPQKAVLLL EHVERKETPG LKLIILMDPF EEALKERGQK
       250        260        270        280        290        300
CGVVIKSMQA VEDCGQENHQ APVPPQPDDL SIVCFTSGTT GNPKGAMLTH GNVVADFSGF
       310        320        330        340        350        360
LKVTEKVIFP RQDDVLISFL PLAHMFERVI QSVVYCHGGR VGFFQGDIRL LSDDMKALCP
       370        380        390        400        410        420
TIFPVVPRLL NRMYDKIFSQ ANTPLKRWLL EFAAKRKQAE VRSGIIRNDS IWDELFFNKI
       430        440        450        460        470        480
QASLGGCVRM IVTGAAPASP TVLGFLRAAL GCQVYEGYGQ TECTAGCTFT TPGDWTSGHV
       490        500        510        520        530        540
GAPLPCNHIK LVDVEELNYW ACKGEGEICV RGPNVFKGYL KDPDRTKEAL DSDGWLHTGD
       550        560        570        580        590        600
IGKWLPAGTL KIIDRKKHIF KLAQGEYVAP EKIENIYIRS QPVAQIYVHG DSLKAFLVGI
       610        620        630        640        650        660
VVPDPEVMPS WAQKRGIEGT YADLCTNKDL KKAILEDMVR LGKESGLHSF EQVKAIHIHS
       670        680        690
DMFSVQNGLL TPTLKAKRPE LREYFKKQIE ELYSISM         10         20         30         40         50         60
MQTQEILRIL RLPELGDLGQ FFRSLSATTL VSMGALAAIL AYWFTHRPKA LQPPCNLLMQ
        70         80         90        100        110        120
SEEVEDSGGA RRSVIGSGPQ LLTHYYDDAR TMYQVFRRGL SISGNGPCLG FRKPKQPYQW
       130        140        150        160        170        180
LSYQEVADRA EFLGSGLLQH NCKACTDQFI GVFAQNRPEW IIVELACYTY SMVVVPLYDT
       190        200        210        220        230        240
LGPGAIRYII NTADISTVIV DKPQKAVLLL EHVERKETPG LKLIILMDPF EEALKERGQK
       250        260        270        280        290        300
CGVVIKSMQA VEDCGQENHQ APVPPQPDDL SIVCFTSGTT GNPKGAMLTH GNVVADFSGF
       310        320        330        340        350        360
LKVTEKVIFP RQDDVLISFL PLAHMFERVI QSVVYCHGGR VGFFQGDIRL LSDDMKALCP
       370        380        390        400        410        420
TIFPVVPRLL NRMYDKIFSQ ANTPLKRWLL EFAAKRKQAE VRSGIIRNDS IWDELFFNKI
       430        440        450        460        470        480
QASLGGCVRM IVTGAAPASP TVLGFLRAAL GCQVYEGYGQ TECTAGCTFT TPGDWTSGHV
       490        500        510        520        530        540
GAPLPCNHIK LVDVEELNYW ACKGEGEICV RGPNVFKGYL KDPDRTKEAL DSDGWLHTGD
       550        560        570        580        590        600
IGKWLPAGTL KIIDRKKHIF KLAQGEYVAP EKIENIYIRS QPVAQIYVHG DSLKAFLVGI
       610        620        630        640        650        660
VVPDPEVMPS WAQKRGIEGT YADLCTNKDL KKAILEDMVR LGKESGLHSF EQVKAIHIHS
       670        680        690
DMFSVQNGLL TPTLKAKRPE LREYFKKQIE ELYSISM         10         20         30         40         50         60
MQTQEILRIL RLPELGDLGQ FFRSLSATTL VSMGALAAIL AYWFTHRPKA LQPPCNLLMQ
        70         80         90        100        110        120
SEEVEDSGGA RRSVIGSGPQ LLTHYYDDAR TMYQVFRRGL SISGNGPCLG FRKPKQPYQW
       130        140        150        160        170        180
LSYQEVADRA EFLGSGLLQH NCKACTDQFI GVFAQNRPEW IIVELACYTY SMVVVPLYDT
       190        200        210        220        230        240
LGPGAIRYII NTADISTVIV DKPQKAVLLL EHVERKETPG LKLIILMDPF EEALKERGQK
       250        260        270        280        290        300
CGVVIKSMQA VEDCGQENHQ APVPPQPDDL SIVCFTSGTT GNPKGAMLTH GNVVADFSGF
       310        320        330        340        350        360
LKVTEKVIFP RQDDVLISFL PLAHMFERVI QSVVYCHGGR VGFFQGDIRL LSDDMKALCP
       370        380        390        400        410        420
TIFPVVPRLL NRMYDKIFSQ ANTPLKRWLL EFAAKRKQAE VRSGIIRNDS IWDELFFNKI
       430        440        450        460        470        480
QASLGGCVRM IVTGAAPASP TVLGFLRAAL GCQVYEGYGQ TECTAGCTFT TPGDWTSGHV
       490        500        510        520        530        540
GAPLPCNHIK LVDVEELNYW ACKGEGEICV RGPNVFKGYL KDPDRTKEAL DSDGWLHTGD
       550        560        570        580        590        600
IGKWLPAGTL KIIDRKKHIF KLAQGEYVAP EKIENIYIRS QPVAQIYVHG DSLKAFLVGI
       610        620        630        640        650        660
VVPDPEVMPS WAQKRGIEGT YADLCTNKDL KKAILEDMVR LGKESGLHSF EQVKAIHIHS
       670        680        690
DMFSVQNGLL TPTLKAKRPE LREYFKKQIE ELYSISM

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9UKU0-1-unknown	MQTQEI...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9UKU0-1-unknown	MQTQEI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66211
Q9UKU0-1-unknown	MQTQEI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66212
Q9UKU0-1-unknown	MQTQEI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66213
Q9UKU0-1-unknown	MQTQEI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66214
Q9UKU0-1-unknown	MQTQEI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66215
Q9UKU0-1-unknown	MQTQEI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt104901
Q9UKU0-1-unknown	MQTQEI...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt104902
Q9UKU0-179-unknown	DTLGPG...	179	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4280
Q9UKU0-179-unknown	DTLGPG...	179	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144500
Q9UKU0-179-unknown	DTLGPG...	179	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145867
Q9UKU0-179-unknown	DTLGPG...	179	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145868
Q9UKU0-179-unknown	DTLGPG...	179	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145869
Q9UKU0-179-unknown	DTLGPG...	179	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146256
Q9UKU0-179-unknown	DTLGPG...	179	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146671

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VVPLYD	178	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4280
...VVPLYD	178	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127765
...VVPLYD	178	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129164
...VVPLYD	178	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129165
...VVPLYD	178	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129166
...VVPLYD	178	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129167
...VVPLYD	178	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129560
...VVPLYD	178	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129981
...YSISM	697	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...YSISM	697	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61833
...YSISM	697	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61831
...YSISM	697	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61830
...YSISM	697	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61835
...YSISM	697	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61832
...YSISM	697	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61834

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	178	PLYD.\|.DTLG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)