Q9ULC6: Protein-arginine deiminase type-1

General Information

Protein names	- Protein-arginine deiminase type-1 - 3.5.3.15 {ECO:0000269\|PubMed:12416996, ECO:0000269\|PubMed:27393304} - Peptidylarginine deiminase I - Protein-arginine deiminase type I
Gene names	PADI1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9ULC6

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAPKRVVQLS LKMPTHAVCV VGVEAHVDIH SDVPKGANSF RVSGSSGVEV FMVYNRTRVK
        70         80         90        100        110        120
EPIGKARWPL DTDADMVVSV GTASKELKDF KVRVSYFGEQ EDQALGRSVL YLTGVDISLE
       130        140        150        160        170        180
VDTGRTGKVK RSQGDKKTWR WGPEGYGAIL LVNCDRDNHR SAEPDLTHSW LMSLADLQDM
       190        200        210        220        230        240
SPMLLSCNGP DKLFDSHKLV LNVPFSDSKR VRVFCARGGN SLSDYKQVLG PQCLSYEVER
       250        260        270        280        290        300
QPGEQEIKFY VEGLTFPDAD FLGLVSLSVS LVDPGTLPEV TLFTDTVGFR MAPWIMTPNT
       310        320        330        340        350        360
QPPEELYVCR VMDTHGSNEK FLEDMSYLTL KANCKLTICP QVENRNDRWI QDEMEFGYIE
       370        380        390        400        410        420
APHKSFPVVF DSPRNRGLKD FPYKRILGPD FGYVTREIPL PGPSSLDSFG NLDVSPPVTV
       430        440        450        460        470        480
GGTEYPLGRI LIGSSFPKSG GRQMARAVRN FLKAQQVQAP VELYSDWLSV GHVDEFLTFV
       490        500        510        520        530        540
PTSDQKGFRL LLASPSACLK LFQEKKEEGY GEAAQFDGLK HQAKRSINEM LADRHLQRDN
       550        560        570        580        590        600
LHAQKCIDWN RNVLKRELGL AESDIVDIPQ LFFLKNFYAE AFFPDMVNMV VLGKYLGIPK
       610        620        630        640        650        660
PYGPIINGRC CLEEKVQSLL EPLGLHCIFI DDYLSYHELQ GEIHCGTNVR RKPFPFKWWN

MVP

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9ULC6-1-unknown	MAPKRV...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9ULC6-31-unknown	SDVPKG...	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8144
Q9ULC6-444-unknown	MARAVR...	444	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000444032
Q9ULC6-444-unknown	MARAVR...	444	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396697
Q9ULC6-530-unknown	MLADRH...	530	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000444833

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...HVDIHS	30	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8144
	...WNMVP	663	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	30	DIHS.\|.SDVP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)