Q9UMY4: Sorting nexin-12

General Information

Protein names	- Sorting nexin-12
Gene names	SNX12
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UMY4

5 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Sorting nexin-12 - Isoform 3 of Sorting nexin-12

Sequence View

        10         20         30         40         50         60
MSDTAVADTR RLNSKPQDLT DAYGPPSNFL EIDIFNPQTV GVGRARFTTY EVRMRTNLPI
        70         80         90        100        110        120
FKLKESCVRR RYSDFEWLKN ELERDSKIVV PPLPGKALKR QLPFRGDEGI FEESFIEERR
       130        140        150        160        170
QGLEQFINKI AGHPLAQNER CLHMFLQEEA IDRNYVPGKS LAVSCPGWSA VA         10         20         30         40         50         60
MSDTAVADTR RLNSKPQDLT DAYGPPSNFL EIDIFNPQTV GVGRARFTTY EVRMRTNLPI
        70         80         90        100        110        120
FKLKESCVRR RYSDFEWLKN ELERDSKIVV PPLPGKALKR QLPFRGDEGI FEESFIEERR
       130        140        150        160        170
QGLEQFINKI AGHPLAQNER CLHMFLQEEA IDRNYVPGKS LAVSCPGWSA VA

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UMY4-2-unknown	MSDTAV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UMY4-1-unknown	MSDTAV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90164
Q9UMY4-1-unknown	MSDTAV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90165
Q9UMY4-2-Acetylation	SDTAVA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UMY4-2-Acetylation	SDTAVA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9UMY4-2-Acetylation	SDTAVA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9UMY4-2-Acetylation	SDTAVA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111415
Q9UMY4-2-Acetylation	SDTAVA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111416
Q9UMY4-22-unknown	AYGPPS...	22			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9UMY4-22-unknown	AYGPPS...	22		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162113
Q9UMY4-22-unknown	AYGPPS...	22		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162114
Q9UMY4-22-	AYGPPS...	22			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q9UMY4-22-	AYGPPS...	22			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9UMY4-22-	AYGPPS...	22			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9UMY4-22-	AYGPPS...	22			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9UMY4-22-	AYGPPS...	22			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UMY4-22-	AYGPPS...	22			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9UMY4-22-	AYGPPS...	22			Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
Q9UMY4-22-	AYGPPS...	22			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...WSAVA	172	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)