Q9UNN5: FAS-associated factor 1

General Information

Protein names	- FAS-associated factor 1 - hFAF1 - UBX domain-containing protein 12 - UBX domain-containing protein 3A
Gene names	FAF1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UNN5

7 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASNMDREMI LADFQACTGI ENIDEAITLL EQNNWDLVAA INGVIPQENG ILQSEYGGET
        70         80         90        100        110        120
IPGPAFNPAS HPASAPTSSS SSAFRPVMPS RQIVERQPRM LDFRVEYRDR NVDVVLEDTC
       130        140        150        160        170        180
TVGEIKQILE NELQIPVSKM LLKGWKTGDV EDSTVLKSLH LPKNNSLYVL TPDLPPPSSS
       190        200        210        220        230        240
SHAGALQESL NQNFMLIITH REVQREYNLN FSGSSTIQEV KRNVYDLTSI PVRHQLWEGW
       250        260        270        280        290        300
PTSATDDSMC LAESGLSYPC HRLTVGRRSS PAQTREQSEE QITDVHMVSD SDGDDFEDAT
       310        320        330        340        350        360
EFGVDDGEVF GMASSALRKS PMMPENAENE GDALLQFTAE FSSRYGDCHP VFFIGSLEAA
       370        380        390        400        410        420
FQEAFYVKAR DRKLLAIYLH HDESVLTNVF CSQMLCAESI VSYLSQNFIT WAWDLTKDSN
       430        440        450        460        470        480
RARFLTMCNR HFGSVVAQTI RTQKTDQFPL FLIIMGKRSS NEVLNVIQGN TTVDELMMRL
       490        500        510        520        530        540
MAAMEIFTAQ QQEDIKDEDE REARENVKRE QDEAYRLSLE ADRAKREAHE REMAEQFRLE
       550        560        570        580        590        600
QIRKEQEEER EAIRLSLEQA LPPEPKEENA EPVSKLRIRT PSGEFLERRF LASNKLQIVF
       610        620        630        640        650
DFVASKGFPW DEYKLLSTFP RRDVTQLDPN KSLLEVKLFP QETLFLEAKE

Isoforms

- Isoform Short of FAS-associated factor 1

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UNN5-1-unknown	MASNMD...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UNN5-1-unknown	MASNMD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt74731
Q9UNN5-65-unknown	AFNPAS...	65	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178128
Q9UNN5-65-	AFNPAS...	65		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9UNN5-74-	SAPTSS...	74		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9UNN5-74-unknown	SAPTSS...	74	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178130
Q9UNN5-306-unknown	DGEVFG...	306	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13551
Q9UNN5-309-	VFGMAS...	309		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EFGVDD	305	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13551
...LEAKE	650	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LEAKE	650	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70349

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	305	GVDD.\|.DGEV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)