Q9Y287: Integral membrane protein 2B

General Information

Protein names	- Integral membrane protein 2B - Immature BRI2 - imBRI2 - Protein E25B - Transmembrane protein BRI - Bri - BRI2, membrane form - Mature BRI2 - mBRI2 - BRI2 intracellular domain - BRI2 ICD - BRI2C, soluble form - Bri23 peptide - Bri2-23 - ABri23 - C-terminal peptide - P23 peptide
Gene names	ITM2B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y287

7 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVKVTFNSAL AQKEAKKDEP KSGEEALIIP PDAVAVDCKD PDDVVPVGQR RAWCWCMCFG
        70         80         90        100        110        120
LAFMLAGVIL GGAYLYKYFA LQPDDVYYCG IKYIKDDVIL NEPSADAPAA LYQTIEENIK
       130        140        150        160        170        180
IFEEEEVEFI SVPVPEFADS DPANIVHDFN KKLTAYLDLN LDKCYVIPLN TSIVMPPRNL
       190        200        210        220        230        240
LELLINIKAG TYLPQSYLIH EHMVITDRIE NIDHLGFFIY RLCHDKETYK LQRRETIKGI
       250        260
QKREASNCFA IRHFENKFAV ETLICS

Isoforms

- Isoform 2 of Integral membrane protein 2B

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y287-0-unknown	SMVKVT...	0	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y287-1-unknown	MVKVTF...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y287-4-unknown	VTFNSA...	4		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9Y287-4-	VTFNSA...	4		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9Y287-111-	LYQTIE...	111		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y287-131-	SVPVPE...	131		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y287-244-unknown	EASNCF...	244	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9857

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...	0	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GIQKRE	243	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GIQKRE	243	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9857
...TLICS	266	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
FURIN_HUMAN	243	QKRE.\|.EASN	inferred from experiment	unknown	MEROPS		Merops FURIN_HUMAN -> ITM2B_HUMAN @243

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)