Q9Y2L1: Exosome complex exonuclease RRP44
Protein names | - Exosome complex exonuclease RRP44 - 3.1.13.- - 3.1.26.- - Protein DIS3 homolog - Ribosomal RNA-processing protein 44 |
---|---|
Gene names | DIS3 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q9Y2L1 |
3
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MLKSKTFLKK TRAGGVMKIV REHYLRDDIG CGAPGCAACG GAHEGPALEP QPQDPASSVC
70 80 90 100 110 120
PQPHYLLPDT NVLLHQIDVL EDPAIRNVIV LQTVLQEVRN RSAPVYKRIR DVTNNQEKHF
130 140 150 160 170 180
YTFTNEHHRE TYVEQEQGEN ANDRNDRAIR VAAKWYNEHL KKMSADNQLQ VIFITNDRRN
190 200 210 220 230 240
KEKAIEEGIP AFTCEEYVKS LTANPELIDR LACLSEEGNE IESGKIIFSE HLPLSKLQQG
250 260 270 280 290 300
IKSGTYLQGT FRASRENYLE ATVWIHGDNE ENKEIILQGL KHLNRAVHED IVAVELLPKS
310 320 330 340 350 360
QWVAPSSVVL HDEGQNEEDV EKEEETERML KTAVSEKMLK PTGRVVGIIK RNWRPYCGML
370 380 390 400 410 420
SKSDIKESRR HLFTPADKRI PRIRIETRQA STLEGRRIIV AIDGWPRNSR YPNGHFVRNL
430 440 450 460 470 480
GDVGEKETET EVLLLEHDVP HQPFSQAVLS FLPKMPWSIT EKDMKNREDL RHLCICSVDP
490 500 510 520 530 540
PGCTDIDDAL HCRELENGNL EVGVHIADVS HFIRPGNALD QESARRGTTV YLCEKRIDMV
550 560 570 580 590 600
PELLSSNLCS LKCDVDRLAF SCIWEMNHNA EILKTKFTKS VINSKASLTY AEAQLRIDSA
610 620 630 640 650 660
NMNDDITTSL RGLNKLAKIL KKRRIEKGAL TLSSPEVRFH MDSETHDPID LQTKELRETN
670 680 690 700 710 720
SMVEEFMLLA NISVAKKIHE EFSEHALLRK HPAPPPSNYE ILVKAARSRN LEIKTDTAKS
730 740 750 760 770 780
LAESLDQAES PTFPYLNTLL RILATRCMMQ AVYFCSGMDN DFHHYGLASP IYTHFTSPIR
790 800 810 820 830 840
RYADVIVHRL LAVAIGADCT YPELTDKHKL ADICKNLNFR HKMAQYAQRA SVAFHTQLFF
850 860 870 880 890 900
KSKGIVSEEA YILFVRKNAI VVLIPKYGLE GTVFFEEKDK PNPQLIYDDE IPSLKIEDTV
910 920 930 940 950
FHVFDKVKVK IMLDSSNLQH QKIRMSLVEP QIPGISIPTD TSNMDLNGPK KKKMKLGK
Isoforms
- Isoform 2 of Exosome complex exonuclease RRP44Sequence View
10 20 30 40 50 60
MLKSKTFLKK TRAGGVMKIV REHYLRDDIG CGAPGCAACG GAHEGPALEP QPQDPASSVC
70 80 90 100 110 120
PQPHYLLPDT NVLLHQIDVL EDPAIRNVIV LQTVLQEVRN RSAPVYKRIR DVTNNQEKHF
130 140 150 160 170 180
YTFTNEHHRE TYVEQEQGEN ANDRNDRAIR VAAKWYNEHL KKMSADNQLQ VIFITNDRRN
190 200 210 220 230 240
KEKAIEEGIP AFTCEEYVKS LTANPELIDR LACLSEEGNE IESGKIIFSE HLPLSKLQQG
250 260 270 280 290 300
IKSGTYLQGT FRASRENYLE ATVWIHGDNE ENKEIILQGL KHLNRAVHED IVAVELLPKS
310 320 330 340 350 360
QWVAPSSVVL HDEGQNEEDV EKEEETERML KTAVSEKMLK PTGRVVGIIK RNWRPYCGML
370 380 390 400 410 420
SKSDIKESRR HLFTPADKRI PRIRIETRQA STLEGRRIIV AIDGWPRNSR YPNGHFVRNL
430 440 450 460 470 480
GDVGEKETET EVLLLEHDVP HQPFSQAVLS FLPKMPWSIT EKDMKNREDL RHLCICSVDP
490 500 510 520 530 540
PGCTDIDDAL HCRELENGNL EVGVHIADVS HFIRPGNALD QESARRGTTV YLCEKRIDMV
550 560 570 580 590 600
PELLSSNLCS LKCDVDRLAF SCIWEMNHNA EILKTKFTKS VINSKASLTY AEAQLRIDSA
610 620 630 640 650 660
NMNDDITTSL RGLNKLAKIL KKRRIEKGAL TLSSPEVRFH MDSETHDPID LQTKELRETN
670 680 690 700 710 720
SMVEEFMLLA NISVAKKIHE EFSEHALLRK HPAPPPSNYE ILVKAARSRN LEIKTDTAKS
730 740 750 760 770 780
LAESLDQAES PTFPYLNTLL RILATRCMMQ AVYFCSGMDN DFHHYGLASP IYTHFTSPIR
790 800 810 820 830 840
RYADVIVHRL LAVAIGADCT YPELTDKHKL ADICKNLNFR HKMAQYAQRA SVAFHTQLFF
850 860 870 880 890 900
KSKGIVSEEA YILFVRKNAI VVLIPKYGLE GTVFFEEKDK PNPQLIYDDE IPSLKIEDTV
910 920 930 940 950
FHVFDKVKVK IMLDSSNLQH QKIRMSLVEP QIPGISIPTD TSNMDLNGPK KKKMKLGK
Protein Neighborhood
Domains & Features
3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q9Y2L1-1-unknown | MLKSKT... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt88258 | |||
Q9Y2L1-1-Acetylation | MLKSKT... | 1 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
Q9Y2L1-1-Acetylation | MLKSKT... | 1 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
Q9Y2L1-1-Acetylation | MLKSKT... | 1 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
Q9Y2L1-1-Acetylation | MLKSKT... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt108447 | ||
Q9Y2L1-320-unknown | VEKEEE... | 320 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13601 | |||
Q9Y2L1-320-unknown | VEKEEE... | 320 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt149573 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...QNEEDV | 319 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13601 | |||
...QNEEDV | 319 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt132961 | |||
...MKLGK | 958 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...MKLGK | 958 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt83876 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 319 | EEDV.|.VEKE | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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