Q9Y3B8: Oligoribonuclease, mitochondrial

General Information

Protein names	- Oligoribonuclease, mitochondrial - 3.1.-.- - RNA exonuclease 2 homolog - Small fragment nuclease
Gene names	REXO2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y3B8

5 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Oligoribonuclease, mitochondrial - Isoform 3 of Oligoribonuclease, mitochondrial

Sequence View

        10         20         30         40         50         60
MLGGSLGSRL LRGVGGSHGR FGARGVREGG AAMAAGESMA QRMVWVDLEM TGLDIEKDQI
        70         80         90        100        110        120
IEMACLITDS DLNILAEGPN LIIKQPDELL DSMSDWCKEH HGKSGLTKAV KESTITLQQA
       130        140        150        160        170        180
EYEFLSFVRQ QTPPGLCPLA GNSVHEDKKF LDKYMPQFMK HLHYRIIDVS TVKELCRRWY
       190        200        210        220        230
PEEYEFAPKK AASHRALDDI SESIKELQFY RNNIFKKKID EKKRKIIENG ENEKTVS         10         20         30         40         50         60
MLGGSLGSRL LRGVGGSHGR FGARGVREGG AAMAAGESMA QRMVWVDLEM TGLDIEKDQI
        70         80         90        100        110        120
IEMACLITDS DLNILAEGPN LIIKQPDELL DSMSDWCKEH HGKSGLTKAV KESTITLQQA
       130        140        150        160        170        180
EYEFLSFVRQ QTPPGLCPLA GNSVHEDKKF LDKYMPQFMK HLHYRIIDVS TVKELCRRWY
       190        200        210        220        230
PEEYEFAPKK AASHRALDDI SESIKELQFY RNNIFKKKID EKKRKIIENG ENEKTVS

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y3B8-1-acetylation	MLGGSL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9Y3B8-1-acetylation	MLGGSL...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9Y3B8-26-unknown	VREGGA...	26		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y3B8-33-unknown	MAAGES...	33		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83826
Q9Y3B8-34-acetylation	AAGESM...	34	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q9Y3B8-34-acetylation	AAGESM...	34	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183279
Q9Y3B8-39-unknown	MAQRMV...	39		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83825
Q9Y3B8-39-unknown	MAQRMV...	39		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt102352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...EKTVS	237		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...EKTVS	237		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...EKTVS	237	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...EKTVS	237	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt79443
...EKTVS	237	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt79444
...EKTVS	237		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...EKTVS	237		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)