Q9Y5T5: Ubiquitin carboxyl-terminal hydrolase 16 {ECO:0000255|HAMAP-Rule:MF_03062}

General Information

Protein names	- Ubiquitin carboxyl-terminal hydrolase 16 {ECO:0000255\|HAMAP-Rule:MF_03062} - 3.4.19.12 {ECO:0000255\|HAMAP-Rule:MF_03062} - Deubiquitinating enzyme 16 {ECO:0000255\|HAMAP-Rule:MF_03062} - Ubiquitin thioesterase 16 {ECO:0000255\|HAMAP-Rule:MF_03062} - Ubiquitin-processing protease UBP-M - Ubiquitin-specific-processing protease 16 {ECO:0000255\|HAMAP-Rule:MF_03062}
Gene names	USP16
Organism	Homo sapiens
Protease Family
Protease ID	C19.021
Chromosome location
UniProt ID	Q9Y5T5

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 16 - Isoform 3 of Ubiquitin carboxyl-terminal hydrolase 16 - Isoform 4 of Ubiquitin carboxyl-terminal hydrolase 16 - Isoform 5 of Ubiquitin carboxyl-terminal hydrolase 16

Sequence View

        10         20         30         40         50         60
MGKKRTKGKT VPIDDSSETL EPVCRHIRKG LEQGNLKKAL VNVEWNICQD CKTDNKVKDK
        70         80         90        100        110        120
AEEETEEKPS VWLCLKCGHQ GCGRNSQEQH ALKHYLTPRS EPHCLVLSLD NWSVWCYVCD
       130        140        150        160        170        180
NEVQYCSSNQ LGQVVDYVRK QASITTPKPA EKDNGNIELE NKKLEKESKN EQEREKKENM
       190        200        210        220        230        240
AKENPPMNSP CQITVKGLSN LGNTCFFNAV MQNLSQTPVL RELLKEVKMS GTIVKIEPPD
       250        260        270        280        290        300
LALTEPLEIN LEPPGPLTLA MSQFLNEMQE TKKGVVTPKE LFSQVCKKAV RFKGYQQQDS
       310        320        330        340        350        360
QELLRYLLDG MRAEEHQRVS KGILKAFGNS TEKLDEELKN KVKDYEKKKS MPSFVDRIFG
       370        380        390        400        410        420
GELTSMIMCD QCRTVSLVHE SFLDLSLPVL DDQSGKKSVN DKNLKKTVED EDQDSEEEKD
       430        440        450        460        470        480
NDSYIKERSD IPSGTSKHLQ KKAKKQAKKQ AKNQRRQQKI QGKVLHLNDI CTIDHPEDSE
       490        500        510        520        530        540
YEAEMSLQGE VNIKSNHISQ EGVMHKEYCV NQKDLNGQAK MIESVTDNQK STEEVDMKNI
       550        560        570        580        590        600
NMDNDLEVLT SSPTRNLNGA YLTEGSNGEV DISNGFKNLN LNAALHPDEI NIEILNDSHT
       610        620        630        640        650        660
PGTKVYEVVN EDPETAFCTL ANREVFNTDE CSIQHCLYQF TRNEKLRDAN KLLCEVCTRR
       670        680        690        700        710        720
QCNGPKANIK GERKHVYTNA KKQMLISLAP PVLTLHLKRF QQAGFNLRKV NKHIKFPEIL
       730        740        750        760        770        780
DLAPFCTLKC KNVAEENTRV LYSLYGVVEH SGTMRSGHYT AYAKARTANS HLSNLVLHGD
       790        800        810        820
IPQDFEMESK GQWFHISDTH VQAVPTTKVL NSQAYLLFYE RIL         10         20         30         40         50         60
MGKKRTKGKT VPIDDSSETL EPVCRHIRKG LEQGNLKKAL VNVEWNICQD CKTDNKVKDK
        70         80         90        100        110        120
AEEETEEKPS VWLCLKCGHQ GCGRNSQEQH ALKHYLTPRS EPHCLVLSLD NWSVWCYVCD
       130        140        150        160        170        180
NEVQYCSSNQ LGQVVDYVRK QASITTPKPA EKDNGNIELE NKKLEKESKN EQEREKKENM
       190        200        210        220        230        240
AKENPPMNSP CQITVKGLSN LGNTCFFNAV MQNLSQTPVL RELLKEVKMS GTIVKIEPPD
       250        260        270        280        290        300
LALTEPLEIN LEPPGPLTLA MSQFLNEMQE TKKGVVTPKE LFSQVCKKAV RFKGYQQQDS
       310        320        330        340        350        360
QELLRYLLDG MRAEEHQRVS KGILKAFGNS TEKLDEELKN KVKDYEKKKS MPSFVDRIFG
       370        380        390        400        410        420
GELTSMIMCD QCRTVSLVHE SFLDLSLPVL DDQSGKKSVN DKNLKKTVED EDQDSEEEKD
       430        440        450        460        470        480
NDSYIKERSD IPSGTSKHLQ KKAKKQAKKQ AKNQRRQQKI QGKVLHLNDI CTIDHPEDSE
       490        500        510        520        530        540
YEAEMSLQGE VNIKSNHISQ EGVMHKEYCV NQKDLNGQAK MIESVTDNQK STEEVDMKNI
       550        560        570        580        590        600
NMDNDLEVLT SSPTRNLNGA YLTEGSNGEV DISNGFKNLN LNAALHPDEI NIEILNDSHT
       610        620        630        640        650        660
PGTKVYEVVN EDPETAFCTL ANREVFNTDE CSIQHCLYQF TRNEKLRDAN KLLCEVCTRR
       670        680        690        700        710        720
QCNGPKANIK GERKHVYTNA KKQMLISLAP PVLTLHLKRF QQAGFNLRKV NKHIKFPEIL
       730        740        750        760        770        780
DLAPFCTLKC KNVAEENTRV LYSLYGVVEH SGTMRSGHYT AYAKARTANS HLSNLVLHGD
       790        800        810        820
IPQDFEMESK GQWFHISDTH VQAVPTTKVL NSQAYLLFYE RIL         10         20         30         40         50         60
MGKKRTKGKT VPIDDSSETL EPVCRHIRKG LEQGNLKKAL VNVEWNICQD CKTDNKVKDK
        70         80         90        100        110        120
AEEETEEKPS VWLCLKCGHQ GCGRNSQEQH ALKHYLTPRS EPHCLVLSLD NWSVWCYVCD
       130        140        150        160        170        180
NEVQYCSSNQ LGQVVDYVRK QASITTPKPA EKDNGNIELE NKKLEKESKN EQEREKKENM
       190        200        210        220        230        240
AKENPPMNSP CQITVKGLSN LGNTCFFNAV MQNLSQTPVL RELLKEVKMS GTIVKIEPPD
       250        260        270        280        290        300
LALTEPLEIN LEPPGPLTLA MSQFLNEMQE TKKGVVTPKE LFSQVCKKAV RFKGYQQQDS
       310        320        330        340        350        360
QELLRYLLDG MRAEEHQRVS KGILKAFGNS TEKLDEELKN KVKDYEKKKS MPSFVDRIFG
       370        380        390        400        410        420
GELTSMIMCD QCRTVSLVHE SFLDLSLPVL DDQSGKKSVN DKNLKKTVED EDQDSEEEKD
       430        440        450        460        470        480
NDSYIKERSD IPSGTSKHLQ KKAKKQAKKQ AKNQRRQQKI QGKVLHLNDI CTIDHPEDSE
       490        500        510        520        530        540
YEAEMSLQGE VNIKSNHISQ EGVMHKEYCV NQKDLNGQAK MIESVTDNQK STEEVDMKNI
       550        560        570        580        590        600
NMDNDLEVLT SSPTRNLNGA YLTEGSNGEV DISNGFKNLN LNAALHPDEI NIEILNDSHT
       610        620        630        640        650        660
PGTKVYEVVN EDPETAFCTL ANREVFNTDE CSIQHCLYQF TRNEKLRDAN KLLCEVCTRR
       670        680        690        700        710        720
QCNGPKANIK GERKHVYTNA KKQMLISLAP PVLTLHLKRF QQAGFNLRKV NKHIKFPEIL
       730        740        750        760        770        780
DLAPFCTLKC KNVAEENTRV LYSLYGVVEH SGTMRSGHYT AYAKARTANS HLSNLVLHGD
       790        800        810        820
IPQDFEMESK GQWFHISDTH VQAVPTTKVL NSQAYLLFYE RIL         10         20         30         40         50         60
MGKKRTKGKT VPIDDSSETL EPVCRHIRKG LEQGNLKKAL VNVEWNICQD CKTDNKVKDK
        70         80         90        100        110        120
AEEETEEKPS VWLCLKCGHQ GCGRNSQEQH ALKHYLTPRS EPHCLVLSLD NWSVWCYVCD
       130        140        150        160        170        180
NEVQYCSSNQ LGQVVDYVRK QASITTPKPA EKDNGNIELE NKKLEKESKN EQEREKKENM
       190        200        210        220        230        240
AKENPPMNSP CQITVKGLSN LGNTCFFNAV MQNLSQTPVL RELLKEVKMS GTIVKIEPPD
       250        260        270        280        290        300
LALTEPLEIN LEPPGPLTLA MSQFLNEMQE TKKGVVTPKE LFSQVCKKAV RFKGYQQQDS
       310        320        330        340        350        360
QELLRYLLDG MRAEEHQRVS KGILKAFGNS TEKLDEELKN KVKDYEKKKS MPSFVDRIFG
       370        380        390        400        410        420
GELTSMIMCD QCRTVSLVHE SFLDLSLPVL DDQSGKKSVN DKNLKKTVED EDQDSEEEKD
       430        440        450        460        470        480
NDSYIKERSD IPSGTSKHLQ KKAKKQAKKQ AKNQRRQQKI QGKVLHLNDI CTIDHPEDSE
       490        500        510        520        530        540
YEAEMSLQGE VNIKSNHISQ EGVMHKEYCV NQKDLNGQAK MIESVTDNQK STEEVDMKNI
       550        560        570        580        590        600
NMDNDLEVLT SSPTRNLNGA YLTEGSNGEV DISNGFKNLN LNAALHPDEI NIEILNDSHT
       610        620        630        640        650        660
PGTKVYEVVN EDPETAFCTL ANREVFNTDE CSIQHCLYQF TRNEKLRDAN KLLCEVCTRR
       670        680        690        700        710        720
QCNGPKANIK GERKHVYTNA KKQMLISLAP PVLTLHLKRF QQAGFNLRKV NKHIKFPEIL
       730        740        750        760        770        780
DLAPFCTLKC KNVAEENTRV LYSLYGVVEH SGTMRSGHYT AYAKARTANS HLSNLVLHGD
       790        800        810        820
IPQDFEMESK GQWFHISDTH VQAVPTTKVL NSQAYLLFYE RIL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9Y5T5-1-unknown	MGKKRT...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9Y5T5-1-unknown	MGKKRT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt93644
Q9Y5T5-1-unknown	MGKKRT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt93647
Q9Y5T5-311-unknown	MRAEEH...	311	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt93646
Q9Y5T5-311-unknown	MRAEEH...	311	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt107461
Q9Y5T5-311-unknown	MRAEEH...	311	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt107462
Q9Y5T5-311-unknown	MRAEEH...	311	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt107460
Q9Y5T5-544-unknown	NDLEVL...	544	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13654
Q9Y5T5-544-unknown	NDLEVL...	544	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147874
Q9Y5T5-544-unknown	NDLEVL...	544	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153740
Q9Y5T5-544-unknown	NDLEVL...	544	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153911

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NINMDN	543	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13654
...NINMDN	543	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131230
...NINMDN	543	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137162
...NINMDN	543	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137333
...YERIL	823	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...YERIL	823	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89264
...YERIL	823	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89263
...YERIL	823	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89262

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	543	NMDN.\|.NDLE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)