Q9Y5V3: Melanoma-associated antigen D1

General Information

Protein names	- Melanoma-associated antigen D1 - MAGE tumor antigen CCF - MAGE-D1 antigen - Neurotrophin receptor-interacting MAGE homolog
Gene names	MAGED1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y5V3

12 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAQKMDCGAG LLGFQAEASV EDSALLMQTL MEAIQISEAP PTNQATAAAS PQSSQPPTAN
        70         80         90        100        110        120
EMADIQVSAA AARPKSAFKV QNATTKGPNG VYDFSQAHNA KDVPNTQPKA AFKSQNATPK
       130        140        150        160        170        180
GPNAAYDFSQ AATTGELAAN KSEMAFKAQN ATTKVGPNAT YNFSQSLNAN DLANSRPKTP
       190        200        210        220        230        240
FKAWNDTTKA PTADTQTQNV NQAKMATSQA DIETDPGISE PDGATAQTSA DGSQAQNLES
       250        260        270        280        290        300
RTIIRGKRTR KINNLNVEEN SSGDQRRAPL AAGTWRSAPV PVTTQNPPGA PPNVLWQTPL
       310        320        330        340        350        360
AWQNPSGWQN QTARQTPPAR QSPPARQTPP AWQNPVAWQN PVIWPNPVIW QNPVIWPNPI
       370        380        390        400        410        420
VWPGPVVWPN PLAWQNPPGW QTPPGWQTPP GWQGPPDWQG PPDWPLPPDW PLPPDWPLPT
       430        440        450        460        470        480
DWPLPPDWIP ADWPIPPDWQ NLRPSPNLRP SPNSRASQNP GAAQPRDVAL LQERANKLVK
       490        500        510        520        530        540
YLMLKDYTKV PIKRSEMLRD IIREYTDVYP EIIERACFVL EKKFGIQLKE IDKEEHLYIL
       550        560        570        580        590        600
ISTPESLAGI LGTTKDTPKL GLLLVILGVI FMNGNRASEA VLWEALRKMG LRPGVRHPLL
       610        620        630        640        650        660
GDLRKLLTYE FVKQKYLDYR RVPNSNPPEY EFLWGLRSYH ETSKMKVLRF IAEVQKRDPR
       670        680        690        700        710        720
DWTAQFMEAA DEALDALDAA AAEAEARAEA RTRMGIGDEA VSGPWSWDDI EFELLTWDEE
       730        740        750        760        770
GDFGDPWSRI PFTFWARYHQ NARSRFPQTF AGPIIGPGGT ASANFAANFG AIGFFWVE

Isoforms

- Isoform 2 of Melanoma-associated antigen D1

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

12 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y5V3-1-unknown	MAQKMD...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y5V3-45-unknown	ATAAAS...	45	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167052
Q9Y5V3-45-	ATAAAS...	45		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9Y5V3-45-	ATAAAS...	45		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y5V3-47-	AAASPQ...	47		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y5V3-47-unknown	AAASPQ...	47	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177665
Q9Y5V3-54-	SQPPTA...	54		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9Y5V3-54-unknown	SQPPTA...	54	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167056
Q9Y5V3-223-unknown	GATAQT...	223	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2362
Q9Y5V3-223-unknown	GATAQT...	223	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149310
Q9Y5V3-223-	GATAQT...	223		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y5V3-223-	GATAQT...	223		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y5V3-232-unknown	GSQAQN...	232	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167054
Q9Y5V3-232-	GSQAQN...	232		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9Y5V3-232-	GSQAQN...	232		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y5V3-232-	GSQAQN...	232		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9Y5V3-232-	GSQAQN...	232		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y5V3-679-unknown	AAAAEA...	679	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2364
Q9Y5V3-679-unknown	AAAAEA...	679	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156166

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ISEPDG	222	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2362
...ISEPDG	222	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132695
...LDALDA	678	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2364
...LDALDA	678	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139632
...FFWVE	778	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FFWVE	778	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75925

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	222	EPDG.\|.GATA	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> MAGD1_HUMAN @222
CASP3_HUMAN	678	ALDA.\|.AAAA	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> MAGD1_HUMAN @678

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)