Q9Y613: FH1/FH2 domain-containing protein 1

General Information

Protein names	- FH1/FH2 domain-containing protein 1 - Formin homolog overexpressed in spleen 1 - FHOS - Formin homology 2 domain-containing protein 1
Gene names	FHOD1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y613

7 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGGEDRGDG EPVSVVTVRV QYLEDTDPFA CANFPEPRRA PTCSLDGALP LGAQIPAVHR
        70         80         90        100        110        120
LLGAPLKLED CALQVSPSGY YLDTELSLEE QREMLEGFYE EISKGRKPTL ILRTQLSVRV
       130        140        150        160        170        180
NAILEKLYSS SGPELRRSLF SLKQIFQEDK DLVPEFVHSE GLSCLIRVGA AADHNYQSYI
       190        200        210        220        230        240
LRALGQLMLF VDGMLGVVAH SDTIQWLYTL CASLSRLVVK TALKLLLVFV EYSENNAPLF
       250        260        270        280        290        300
IRAVNSVAST TGAPPWANLV SILEEKNGAD PELLVYTVTL INKTLAALPD QDSFYDVTDA
       310        320        330        340        350        360
LEQQGMEALV QRHLGTAGTD VDLRTQLVLY ENALKLEDGD IEEAPGAGGR RERRKPSSEE
       370        380        390        400        410        420
GKRSRRSLEG GGCPARAPEP GPTGPASPVG PTSSTGPALL TGPASSPVGP PSGLQASVNL
       430        440        450        460        470        480
FPTISVAPSA DTSSERSIYK ARFLENVAAA ETEKQVALAQ GRAETLAGAM PNEAGGHPDA
       490        500        510        520        530        540
RQLWDSPETA PAARTPQSPA PCVLLRAQRS LAPEPKEPLI PASPKAEPIW ELPTRAPRLS
       550        560        570        580        590        600
IGDLDFSDLG EDEDQDMLNV ESVEAGKDIP APSPPLPLLS GVPPPPPLPP PPPIKGPFPP
       610        620        630        640        650        660
PPPLPLAAPL PHSVPDSSAL PTKRKTVKLF WRELKLAGGH GVSASRFGPC ATLWASLDPV
       670        680        690        700        710        720
SVDTARLEHL FESRAKEVLP SKKAGEGRRT MTTVLDPKRS NAINIGLTTL PPVHVIKAAL
       730        740        750        760        770        780
LNFDEFAVSK DGIEKLLTMM PTEEERQKIE EAQLANPDIP LGPAENFLMT LASIGGLAAR
       790        800        810        820        830        840
LQLWAFKLDY DSMEREIAEP LFDLKVGMEQ LVQNATFRCI LATLLAVGNF LNGSQSSGFE
       850        860        870        880        890        900
LSYLEKVSEV KDTVRRQSLL HHLCSLVLQT RPESSDLYSE IPALTRCAKV DFEQLTENLG
       910        920        930        940        950        960
QLERRSRAAE ESLRSLAKHE LAPALRARLT HFLDQCARRV AMLRIVHRRV CNRFHAFLLY
       970        980        990       1000       1010       1020
LGYTPQAARE VRIMQFCHTL REFALEYRTC RERVLQQQQK QATYRERNKT RGRMITETEK
      1030       1040       1050       1060       1070       1080
FSGVAGEAPS NPSVPVAVSS GPGRGDADSH ASMKSLLTSR PEDTTHNRRS RGMVQSSSPI
      1090       1100       1110       1120       1130       1140
MPTVGPSTAS PEEPPGSSLP SDTSDEIMDL LVQSVTKSSP RALAARERKR SRGNRKSLRR
      1150       1160
TLKSGLGDDL VQALGLSKGP GLEV

Isoforms

Sequence View

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(REFRESH)

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

7 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y613-2-	AGGEDR...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y613-2-unknown	AGGEDR...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y613-10-	GEPVSV...	10		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y613-10-	GEPVSV...	10		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9Y613-47-	GALPLG...	47		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9Y613-300-	ALEQQG...	300		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9Y613-300-	ALEQQG...	300		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y613-468-	GAMPNE...	468		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9Y613-468-	GAMPNE...	468		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y613-617-unknown	SSALPT...	617	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2366

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...HSVPDS	616	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2366
...PGLEV	1164	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...PGLEV	1164		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...PGLEV	1164		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...PGLEV	1164		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...PGLEV	1164		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	616	VPDS.\|.SSAL	inferred from experiment	unknown	MEROPS	Roy S	Menard I et al.:Caspase-3 cleaves the formin-ho... (C14.003)	17013756,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)