A0AVT1: Ubiquitin-like modifier-activating enzyme 6
Protein names | - Ubiquitin-like modifier-activating enzyme 6 - Ubiquitin-activating enzyme 6 - 6.2.1.45 {ECO:0000250|UniProtKB:P22314} - Monocyte protein 4 - MOP-4 - Ubiquitin-activating enzyme E1-like protein 2 - E1-L2 |
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Gene names | UBA6 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | A0AVT1 |
7
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MEGSEPVAAH QGEEASCSSW GTGSTNKNLP IMSTASVEID DALYSRQRYV LGDTAMQKMA
70 80 90 100 110 120
KSHVFLSGMG GLGLEIAKNL VLAGIKAVTI HDTEKCQAWD LGTNFFLSED DVVNKRNRAE
130 140 150 160 170 180
AVLKHIAELN PYVHVTSSSV PFNETTDLSF LDKYQCVVLT EMKLPLQKKI NDFCRSQCPP
190 200 210 220 230 240
IKFISADVHG IWSRLFCDFG DEFEVLDTTG EEPKEIFISN ITQANPGIVT CLENHPHKLE
250 260 270 280 290 300
TGQFLTFREI NGMTGLNGSI QQITVISPFS FSIGDTTELE PYLHGGIAVQ VKTPKTVFFE
310 320 330 340 350 360
SLERQLKHPK CLIVDFSNPE APLEIHTAML ALDQFQEKYS RKPNVGCQQD SEELLKLATS
370 380 390 400 410 420
ISETLEEKPD VNADIVHWLS WTAQGFLSPL AAAVGGVASQ EVLKAVTGKF SPLCQWLYLE
430 440 450 460 470 480
AADIVESLGK PECEEFLPRG DRYDALRACI GDTLCQKLQN LNIFLVGCGA IGCEMLKNFA
490 500 510 520 530 540
LLGVGTSKEK GMITVTDPDL IEKSNLNRQF LFRPHHIQKP KSYTAADATL KINSQIKIDA
550 560 570 580 590 600
HLNKVCPTTE TIYNDEFYTK QDVIITALDN VEARRYVDSR CLANLRPLLD SGTMGTKGHT
610 620 630 640 650 660
EVIVPHLTES YNSHRDPPEE EIPFCTLKSF PAAIEHTIQW ARDKFESSFS HKPSLFNKFW
670 680 690 700 710 720
QTYSSAEEVL QKIQSGHSLE GCFQVIKLLS RRPRNWSQCV ELARLKFEKY FNHKALQLLH
730 740 750 760 770 780
CFPLDIRLKD GSLFWQSPKR PPSPIKFDLN EPLHLSFLQN AAKLYATVYC IPFAEEDLSA
790 800 810 820 830 840
DALLNILSEV KIQEFKPSNK VVQTDETARK PDHVPISSED ERNAIFQLEK AILSNEATKS
850 860 870 880 890 900
DLQMAVLSFE KDDDHNGHID FITAASNLRA KMYSIEPADR FKTKRIAGKI IPAIATTTAT
910 920 930 940 950 960
VSGLVALEMI KVTGGYPFEA YKNCFLNLAI PIVVFTETTE VRKTKIRNGI SFTIWDRWTV
970 980 990 1000 1010 1020
HGKEDFTLLD FINAVKEKYG IEPTMVVQGV KMLYVPVMPG HAKRLKLTMH KLVKPTTEKK
1030 1040 1050
YVDLTVSFAP DIDGDEDLPG PPVRYYFSHD TD
Isoforms
- Isoform 2 of Ubiquitin-like modifier-activating enzyme 6 - Isoform 3 of Ubiquitin-like modifier-activating enzyme 6 - Isoform 4 of Ubiquitin-like modifier-activating enzyme 6Sequence View
10 20 30 40 50 60
MEGSEPVAAH QGEEASCSSW GTGSTNKNLP IMSTASVEID DALYSRQRYV LGDTAMQKMA
70 80 90 100 110 120
KSHVFLSGMG GLGLEIAKNL VLAGIKAVTI HDTEKCQAWD LGTNFFLSED DVVNKRNRAE
130 140 150 160 170 180
AVLKHIAELN PYVHVTSSSV PFNETTDLSF LDKYQCVVLT EMKLPLQKKI NDFCRSQCPP
190 200 210 220 230 240
IKFISADVHG IWSRLFCDFG DEFEVLDTTG EEPKEIFISN ITQANPGIVT CLENHPHKLE
250 260 270 280 290 300
TGQFLTFREI NGMTGLNGSI QQITVISPFS FSIGDTTELE PYLHGGIAVQ VKTPKTVFFE
310 320 330 340 350 360
SLERQLKHPK CLIVDFSNPE APLEIHTAML ALDQFQEKYS RKPNVGCQQD SEELLKLATS
370 380 390 400 410 420
ISETLEEKPD VNADIVHWLS WTAQGFLSPL AAAVGGVASQ EVLKAVTGKF SPLCQWLYLE
430 440 450 460 470 480
AADIVESLGK PECEEFLPRG DRYDALRACI GDTLCQKLQN LNIFLVGCGA IGCEMLKNFA
490 500 510 520 530 540
LLGVGTSKEK GMITVTDPDL IEKSNLNRQF LFRPHHIQKP KSYTAADATL KINSQIKIDA
550 560 570 580 590 600
HLNKVCPTTE TIYNDEFYTK QDVIITALDN VEARRYVDSR CLANLRPLLD SGTMGTKGHT
610 620 630 640 650 660
EVIVPHLTES YNSHRDPPEE EIPFCTLKSF PAAIEHTIQW ARDKFESSFS HKPSLFNKFW
670 680 690 700 710 720
QTYSSAEEVL QKIQSGHSLE GCFQVIKLLS RRPRNWSQCV ELARLKFEKY FNHKALQLLH
730 740 750 760 770 780
CFPLDIRLKD GSLFWQSPKR PPSPIKFDLN EPLHLSFLQN AAKLYATVYC IPFAEEDLSA
790 800 810 820 830 840
DALLNILSEV KIQEFKPSNK VVQTDETARK PDHVPISSED ERNAIFQLEK AILSNEATKS
850 860 870 880 890 900
DLQMAVLSFE KDDDHNGHID FITAASNLRA KMYSIEPADR FKTKRIAGKI IPAIATTTAT
910 920 930 940 950 960
VSGLVALEMI KVTGGYPFEA YKNCFLNLAI PIVVFTETTE VRKTKIRNGI SFTIWDRWTV
970 980 990 1000 1010 1020
HGKEDFTLLD FINAVKEKYG IEPTMVVQGV KMLYVPVMPG HAKRLKLTMH KLVKPTTEKK
1030 1040 1050
YVDLTVSFAP DIDGDEDLPG PPVRYYFSHD TD
10 20 30 40 50 60
MEGSEPVAAH QGEEASCSSW GTGSTNKNLP IMSTASVEID DALYSRQRYV LGDTAMQKMA
70 80 90 100 110 120
KSHVFLSGMG GLGLEIAKNL VLAGIKAVTI HDTEKCQAWD LGTNFFLSED DVVNKRNRAE
130 140 150 160 170 180
AVLKHIAELN PYVHVTSSSV PFNETTDLSF LDKYQCVVLT EMKLPLQKKI NDFCRSQCPP
190 200 210 220 230 240
IKFISADVHG IWSRLFCDFG DEFEVLDTTG EEPKEIFISN ITQANPGIVT CLENHPHKLE
250 260 270 280 290 300
TGQFLTFREI NGMTGLNGSI QQITVISPFS FSIGDTTELE PYLHGGIAVQ VKTPKTVFFE
310 320 330 340 350 360
SLERQLKHPK CLIVDFSNPE APLEIHTAML ALDQFQEKYS RKPNVGCQQD SEELLKLATS
370 380 390 400 410 420
ISETLEEKPD VNADIVHWLS WTAQGFLSPL AAAVGGVASQ EVLKAVTGKF SPLCQWLYLE
430 440 450 460 470 480
AADIVESLGK PECEEFLPRG DRYDALRACI GDTLCQKLQN LNIFLVGCGA IGCEMLKNFA
490 500 510 520 530 540
LLGVGTSKEK GMITVTDPDL IEKSNLNRQF LFRPHHIQKP KSYTAADATL KINSQIKIDA
550 560 570 580 590 600
HLNKVCPTTE TIYNDEFYTK QDVIITALDN VEARRYVDSR CLANLRPLLD SGTMGTKGHT
610 620 630 640 650 660
EVIVPHLTES YNSHRDPPEE EIPFCTLKSF PAAIEHTIQW ARDKFESSFS HKPSLFNKFW
670 680 690 700 710 720
QTYSSAEEVL QKIQSGHSLE GCFQVIKLLS RRPRNWSQCV ELARLKFEKY FNHKALQLLH
730 740 750 760 770 780
CFPLDIRLKD GSLFWQSPKR PPSPIKFDLN EPLHLSFLQN AAKLYATVYC IPFAEEDLSA
790 800 810 820 830 840
DALLNILSEV KIQEFKPSNK VVQTDETARK PDHVPISSED ERNAIFQLEK AILSNEATKS
850 860 870 880 890 900
DLQMAVLSFE KDDDHNGHID FITAASNLRA KMYSIEPADR FKTKRIAGKI IPAIATTTAT
910 920 930 940 950 960
VSGLVALEMI KVTGGYPFEA YKNCFLNLAI PIVVFTETTE VRKTKIRNGI SFTIWDRWTV
970 980 990 1000 1010 1020
HGKEDFTLLD FINAVKEKYG IEPTMVVQGV KMLYVPVMPG HAKRLKLTMH KLVKPTTEKK
1030 1040 1050
YVDLTVSFAP DIDGDEDLPG PPVRYYFSHD TD
10 20 30 40 50 60
MEGSEPVAAH QGEEASCSSW GTGSTNKNLP IMSTASVEID DALYSRQRYV LGDTAMQKMA
70 80 90 100 110 120
KSHVFLSGMG GLGLEIAKNL VLAGIKAVTI HDTEKCQAWD LGTNFFLSED DVVNKRNRAE
130 140 150 160 170 180
AVLKHIAELN PYVHVTSSSV PFNETTDLSF LDKYQCVVLT EMKLPLQKKI NDFCRSQCPP
190 200 210 220 230 240
IKFISADVHG IWSRLFCDFG DEFEVLDTTG EEPKEIFISN ITQANPGIVT CLENHPHKLE
250 260 270 280 290 300
TGQFLTFREI NGMTGLNGSI QQITVISPFS FSIGDTTELE PYLHGGIAVQ VKTPKTVFFE
310 320 330 340 350 360
SLERQLKHPK CLIVDFSNPE APLEIHTAML ALDQFQEKYS RKPNVGCQQD SEELLKLATS
370 380 390 400 410 420
ISETLEEKPD VNADIVHWLS WTAQGFLSPL AAAVGGVASQ EVLKAVTGKF SPLCQWLYLE
430 440 450 460 470 480
AADIVESLGK PECEEFLPRG DRYDALRACI GDTLCQKLQN LNIFLVGCGA IGCEMLKNFA
490 500 510 520 530 540
LLGVGTSKEK GMITVTDPDL IEKSNLNRQF LFRPHHIQKP KSYTAADATL KINSQIKIDA
550 560 570 580 590 600
HLNKVCPTTE TIYNDEFYTK QDVIITALDN VEARRYVDSR CLANLRPLLD SGTMGTKGHT
610 620 630 640 650 660
EVIVPHLTES YNSHRDPPEE EIPFCTLKSF PAAIEHTIQW ARDKFESSFS HKPSLFNKFW
670 680 690 700 710 720
QTYSSAEEVL QKIQSGHSLE GCFQVIKLLS RRPRNWSQCV ELARLKFEKY FNHKALQLLH
730 740 750 760 770 780
CFPLDIRLKD GSLFWQSPKR PPSPIKFDLN EPLHLSFLQN AAKLYATVYC IPFAEEDLSA
790 800 810 820 830 840
DALLNILSEV KIQEFKPSNK VVQTDETARK PDHVPISSED ERNAIFQLEK AILSNEATKS
850 860 870 880 890 900
DLQMAVLSFE KDDDHNGHID FITAASNLRA KMYSIEPADR FKTKRIAGKI IPAIATTTAT
910 920 930 940 950 960
VSGLVALEMI KVTGGYPFEA YKNCFLNLAI PIVVFTETTE VRKTKIRNGI SFTIWDRWTV
970 980 990 1000 1010 1020
HGKEDFTLLD FINAVKEKYG IEPTMVVQGV KMLYVPVMPG HAKRLKLTMH KLVKPTTEKK
1030 1040 1050
YVDLTVSFAP DIDGDEDLPG PPVRYYFSHD TD
Protein Neighborhood
Domains & Features
7 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
A0AVT1-1-Acetylation | MEGSEP... | 1 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
A0AVT1-1-Acetylation | MEGSEP... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt98330 | ||
A0AVT1-1-Acetylation | MEGSEP... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt98331 | ||
A0AVT1-1-unknown | MEGSEP... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt93571 | |||
A0AVT1-1-unknown | MEGSEP... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt93572 | |||
A0AVT1-393-unknown | AVGGVA... | 393 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3233 | |||
A0AVT1-396-unknown | GVASQE... | 396 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3234 | |||
A0AVT1-475-unknown | MLKNFA... | 475 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt93570 | |||
A0AVT1-522- | SYTAAD... | 522 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
A0AVT1-522-unknown | SYTAAD... | 522 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171905 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...SPLAAA | 392 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3233 | |||
...AAAVGG | 395 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3234 | |||
...SHDTD | 1052 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...SHDTD | 1052 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt89188 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATB_HUMAN | 392 | LAAA.|.AVGG | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
CATB_HUMAN | 395 | AVGG.|.GVAS | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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