O00217: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

General Information

Protein names	- NADH dehydrogenase ubiquinone] iron-sulfur protein 8, mitochondrial - 1.6.99.3 - 7.1.1.2 - Complex I-23kD - CI-23kD - NADH-ubiquinone oxidoreductase 23 kDa subunit - TYKY subunit
Gene names	NDUFS8
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00217

4 N-termini

5 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRCLTTPMLL RALAQAARAG PPGGRSLHSS AVAATYKYVN MQDPEMDMKS VTDRAARTLL
        70         80         90        100        110        120
WTELFRGLGM TLSYLFREPA TINYPFEKGP LSPRFRGEHA LRRYPSGEER CIACKLCEAI
       130        140        150        160        170        180
CPAQAITIEA EPRADGSRRT TRYDIDMTKC IYCGFCQEAC PVDAIVEGPN FEFSTETHEE
       190        200        210
LLYNKEKLLN NGDKWEAEIA ANIQADYLYR

Isoforms

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 5 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00217-35-unknown	TYKYVN...	35	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00217-35-unknown	TYKYVN...	35		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O00217-35-unknown	TYKYVN...	35	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
O00217-35-	TYKYVN...	35		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O00217-35-	TYKYVN...	35		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O00217-35-	TYKYVN...	35		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O00217-35-	TYKYVN...	35		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O00217-35-	TYKYVN...	35		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O00217-35-	TYKYVN...	35		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O00217-38-	YVNMQD...	38		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O00217-38-	YVNMQD...	38		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O00217-147-unknown	MTKCIY...	147	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000432848

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SGEERC	110	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000432968
...ICPAQA	124	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000403972
...YCGFCQ	156	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000433521
...ELLYNK	184	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000436287
...DYLYR	210	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)