O00411: DNA-directed RNA polymerase, mitochondrial

General Information

Protein names	- DNA-directed RNA polymerase, mitochondrial - MtRPOL - 2.7.7.6
Gene names	POLRMT
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00411

4 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSALCWGRGA AGLKRALRPC GRPGLPGKEG TAGGVCGPRR SSSASPQEQD QDRRKDWGHV
        70         80         90        100        110        120
ELLEVLQARV RQLQAESVSE VVVNRVDVAR LPECGSGDGS LQPPRKVQMG AKDATPVPCG
       130        140        150        160        170        180
RWAKILEKDK RTQQMRMQRL KAKLQMPFQS GEFKALTRRL QVEPRLLSKQ MAGCLEDCTR
       190        200        210        220        230        240
QAPESPWEEQ LARLLQEAPG KLSLDVEQAP SGQHSQAQLS GQQQRLLAFF KCCLLTDQLP
       250        260        270        280        290        300
LAHHLLVVHH GQRQKRKLLT LDMYNAVMLG WARQGAFKEL VYVLFMVKDA GLTPDLLSYA
       310        320        330        340        350        360
AALQCMGRQD QDAGTIERCL EQMSQEGLKL QALFTAVLLS EEDRATVLKA VHKVKPTFSL
       370        380        390        400        410        420
PPQLPPPVNT SKLLRDVYAK DGRVSYPKLH LPLKTLQCLF EKQLHMELAS RVCVVSVEKP
       430        440        450        460        470        480
TLPSKEVKHA RKTLKTLRDQ WEKALCRALR ETKNRLEREV YEGRFSLYPF LCLLDEREVV
       490        500        510        520        530        540
RMLLQVLQAL PAQGESFTTL ARELSARTFS RHVVQRQRVS GQVQALQNHY RKYLCLLASD
       550        560        570        580        590        600
AEVPEPCLPR QYWEELGAPE ALREQPWPLP VQMELGKLLA EMLVQATQMP CSLDKPHRSS
       610        620        630        640        650        660
RLVPVLYHVY SFRNVQQIGI LKPHPAYVQL LEKAAEPTLT FEAVDVPMLC PPLPWTSPHS
       670        680        690        700        710        720
GAFLLSPTKL MRTVEGATQH QELLETCPPT ALHGALDALT QLGNCAWRVN GRVLDLVLQL
       730        740        750        760        770        780
FQAKGCPQLG VPAPPSEAPQ PPEAHLPHSA APARKAELRR ELAHCQKVAR EMHSLRAEAL
       790        800        810        820        830        840
YRLSLAQHLR DRVFWLPHNM DFRGRTYPCP PHFNHLGSDV ARALLEFAQG RPLGPHGLDW
       850        860        870        880        890        900
LKIHLVNLTG LKKREPLRKR LAFAEEVMDD ILDSADQPLT GRKWWMGAEE PWQTLACCME
       910        920        930        940        950        960
VANAVRASDP AAYVSHLPVH QDGSCNGLQH YAALGRDSVG AASVNLEPSD VPQDVYSGVA
       970        980        990       1000       1010       1020
AQVEVFRRQD AQRGMRVAQV LEGFITRKVV KQTVMTVVYG VTRYGGRLQI EKRLRELSDF
      1030       1040       1050       1060       1070       1080
PQEFVWEASH YLVRQVFKSL QEMFSGTRAI QHWLTESARL ISHMGSVVEW VTPLGVPVIQ
      1090       1100       1110       1120       1130       1140
PYRLDSKVKQ IGGGIQSITY THNGDISRKP NTRKQKNGFP PNFIHSLDSS HMMLTALHCY
      1150       1160       1170       1180       1190       1200
RKGLTFVSVH DCYWTHAADV SVMNQVCREQ FVRLHSEPIL QDLSRFLVKR FCSEPQKILE
      1210       1220       1230
ASQLKETLQA VPKPGAFDLE QVKRSTYFFS

Isoforms

Sequence View

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Evidence Codes:

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00411-41-	SSSASP...	41		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O00411-41-	SSSASP...	41		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O00411-41-	SSSASP...	41		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O00411-41-	SSSASP...	41		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O00411-41-unknown	SSSASP...	41		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O00411-42-unknown	SSASPQ...	42	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00411-740-unknown	QPPEAH...	740	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3253

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PSKEVK	427	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000466504
...PSEAPQ	739	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3253
...STYFFS	1229	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000468658
...TYFFS	1230	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	739	EAPQ.\|.QPPE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)