O00425: Insulin-like growth factor 2 mRNA-binding protein 3

General Information

Protein names	- Insulin-like growth factor 2 mRNA-binding protein 3 - IGF2 mRNA-binding protein 3 - IMP-3 - IGF-II mRNA-binding protein 3 - KH domain-containing protein overexpressed in cancer - hKOC - VICKZ family member 3
Gene names	IGF2BP3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00425

6 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MNKLYIGNLS ENAAPSDLES IFKDAKIPVS GPFLVKTGYA FVDCPDESWA LKAIEALSGK
        70         80         90        100        110        120
IELHGKPIEV EHSVPKRQRI RKLQIRNIPP HLQWEVLDSL LVQYGVVESC EQVNTDSETA
       130        140        150        160        170        180
VVNVTYSSKD QARQALDKLN GFQLENFTLK VAYIPDEMAA QQNPLQQPRG RRGLGQRGSS
       190        200        210        220        230        240
RQGSPGSVSK QKPCDLPLRL LVPTQFVGAI IGKEGATIRN ITKQTQSKID VHRKENAGAA
       250        260        270        280        290        300
EKSITILSTP EGTSAACKSI LEIMHKEAQD IKFTEEIPLK ILAHNNFVGR LIGKEGRNLK
       310        320        330        340        350        360
KIEQDTDTKI TISPLQELTL YNPERTITVK GNVETCAKAE EEIMKKIRES YENDIASMNL
       370        380        390        400        410        420
QAHLIPGLNL NALGLFPPTS GMPPPTSGPP SAMTPPYPQF EQSETETVHL FIPALSVGAI
       430        440        450        460        470        480
IGKQGQHIKQ LSRFAGASIK IAPAEAPDAK VRMVIITGPP EAQFKAQGRI YGKIKEENFV
       490        500        510        520        530        540
SPKEEVKLEA HIRVPSFAAG RVIGKGGKTV NELQNLSSAE VVVPRDQTPD ENDQVVVKIT
       550        560        570
GHFYACQVAQ RKIQEILTQV KQHQQQKALQ SGPPQSRRK

Isoforms

- Isoform 2 of Insulin-like growth factor 2 mRNA-binding protein 3

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O00425-1-unknown	MNKLYI...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O00425-117-unknown	SETAVV...	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10639
O00425-248-unknown	STPEGT...	248	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6989
O00425-306-unknown	TDTKIT...	306	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10640
O00425-382-unknown	MPPPTS...	382	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77535
O00425-458-unknown	GPPEAQ...	458	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6990
O00425-458-unknown	GPPEAQ...	458	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141105

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QVNTDS	116	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10639
...SITILS	247	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6989
...KIEQDT	305	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10640
...MVIITG	457	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6990
...MVIITG	457	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124259
...QSRRK	579	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QSRRK	579	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73153

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	116	NTDS.\|.SETA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATS_HUMAN	247	TILS.\|.STPE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	305	EQDT.\|.TDTK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATS_HUMAN	457	IITG.\|.GPPE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)