O00522: Krev interaction trapped protein 1

General Information

Protein names	- Krev interaction trapped protein 1 - Krev interaction trapped 1 - Cerebral cavernous malformations 1 protein
Gene names	KRIT1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00522

4 N-termini

13 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Krev interaction trapped protein 1 - Isoform 3 of Krev interaction trapped protein 1

Sequence View

        10         20         30         40         50         60
MGNPENIEDA YVAVIRPKNT ASLNSREYRA KSYEILLHEV PIEGQKKKRK KVLLETKLQG
        70         80         90        100        110        120
NSEITQGILD YVVETTKPIS PANQGIRGKR VVLMKKFPLD GEKMGREASL FIVPSVVKDN
       130        140        150        160        170        180
TKYTYTPGCP IFYCLQDIMR VCSESSTHFA TLTARMLIAL DKWLDERHAQ SHFIPALFRP
       190        200        210        220        230        240
SPLERIKTNV INPAYATESG QTENSLHMGY SALEIKSKML ALEKADTCIY NPLFGSDLQY
       250        260        270        280        290        300
TNRVDKVVIN PYFGLGAPDY SKIQIPKQEK WQRSMSSVTE DKERQWVDDF PLHRSACEGD
       310        320        330        340        350        360
SELLSRLLSE RFSVNQLDSD HWAPIHYACW YGKVEATRIL LEKGKCNPNL LNGQLSSPLH
       370        380        390        400        410        420
FAAGGGHAEI VQILLNHPET DRHITDQQGR SPLNICEENK QNNWEEAAKL LKEAINKPYE
       430        440        450        460        470        480
KVRIYRMDGS YRSVELKHGN NTTVQQIMEG MRLSQETQQY FTIWICSENL SLQLKPYHKP
       490        500        510        520        530        540
LQHVRDWPEI LAELTNLDPQ RETPQLFLRR DVRLPLEVEK QIEDPLAILI LFDEARYNLL
       550        560        570        580        590        600
KGFYTAPDAK LITLASLLLQ IVYGNYESKK HKQGFLNEEN LKSIVPVTKL KSKAPHWTNR
       610        620        630        640        650        660
ILHEYKNLST SEGVSKEMHH LQRMFLQNCW EIPTYGAAFF TGQIFTKASP SNHKVIPVYV
       670        680        690        700        710        720
GVNIKGLHLL NMETKALLIS LKYGCFMWQL GDTDTCFQIH SMENKMSFIV HTKQAGLVVK
       730
LLMKLNGQLM PTERNS         10         20         30         40         50         60
MGNPENIEDA YVAVIRPKNT ASLNSREYRA KSYEILLHEV PIEGQKKKRK KVLLETKLQG
        70         80         90        100        110        120
NSEITQGILD YVVETTKPIS PANQGIRGKR VVLMKKFPLD GEKMGREASL FIVPSVVKDN
       130        140        150        160        170        180
TKYTYTPGCP IFYCLQDIMR VCSESSTHFA TLTARMLIAL DKWLDERHAQ SHFIPALFRP
       190        200        210        220        230        240
SPLERIKTNV INPAYATESG QTENSLHMGY SALEIKSKML ALEKADTCIY NPLFGSDLQY
       250        260        270        280        290        300
TNRVDKVVIN PYFGLGAPDY SKIQIPKQEK WQRSMSSVTE DKERQWVDDF PLHRSACEGD
       310        320        330        340        350        360
SELLSRLLSE RFSVNQLDSD HWAPIHYACW YGKVEATRIL LEKGKCNPNL LNGQLSSPLH
       370        380        390        400        410        420
FAAGGGHAEI VQILLNHPET DRHITDQQGR SPLNICEENK QNNWEEAAKL LKEAINKPYE
       430        440        450        460        470        480
KVRIYRMDGS YRSVELKHGN NTTVQQIMEG MRLSQETQQY FTIWICSENL SLQLKPYHKP
       490        500        510        520        530        540
LQHVRDWPEI LAELTNLDPQ RETPQLFLRR DVRLPLEVEK QIEDPLAILI LFDEARYNLL
       550        560        570        580        590        600
KGFYTAPDAK LITLASLLLQ IVYGNYESKK HKQGFLNEEN LKSIVPVTKL KSKAPHWTNR
       610        620        630        640        650        660
ILHEYKNLST SEGVSKEMHH LQRMFLQNCW EIPTYGAAFF TGQIFTKASP SNHKVIPVYV
       670        680        690        700        710        720
GVNIKGLHLL NMETKALLIS LKYGCFMWQL GDTDTCFQIH SMENKMSFIV HTKQAGLVVK
       730
LLMKLNGQLM PTERNS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 13 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00522-1-unknown	MGNPEN...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00522-1-unknown	MGNPEN...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79244
O00522-2-	GNPENI...	2		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O00522-2-	GNPENI...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O00522-2-	GNPENI...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O00522-2-	GNPENI...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O00522-2-	GNPENI...	2		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O00522-2-	GNPENI...	2		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O00522-2-	GNPENI...	2		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O00522-2-	GNPENI...	2		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O00522-2-unknown	GNPENI...	2		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O00522-2-unknown	GNPENI...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161744
O00522-208-unknown	MGYSAL...	208	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79243
O00522-208-unknown	MGYSAL...	208	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt103782

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ASLNSR	25	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000395604
...ASLNSR	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153731
...AKSYEI	34	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000388076
...AKSYEI	34	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153770
...EILLHE	38	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000414694
...EILLHE	38	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153796
...LETKLQ	58	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000395346
...LETKLQ	58	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153929
...NSEITQ	65	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396352
...NSEITQ	65	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153977
...TQGILD	69	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000410467
...TQGILD	69	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154024
...LMKKFP	97	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000391540
...LMKKFP	97	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154336
...ASLFIV	112	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396042
...ASLFIV	112	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154501
...IALDKW	162	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405835
...IALDKW	162	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155129
...PSPLER	184	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000410104
...PSPLER	184	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155464
...QYTNRV	243	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000391675
...ENKQNN	402	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000404084
...TERNS	736	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TERNS	736	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74861
...TERNS	736	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74862

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)