O08583: THO complex subunit 4

General Information

Protein names	- THO complex subunit 4 - Tho4 - Ally of AML-1 and LEF-1 - Aly/REF export factor - REF1-I - RNA and export factor-binding protein 1 - Transcriptional coactivator Aly/REF
Gene names	Alyref
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	O08583

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADKMDMSLD DIIKLNRSQR GGRGGGRGRG RAGSQGGRGG AVQAAARVNR GGGPMRNRPA
        70         80         90        100        110        120
IARGAAGGGR NRPAPYSRPK QLPDKWQHDL FDSGFGGGAG VETGGKLLVS NLDFGVSDAD
       130        140        150        160        170        180
IQELFAEFGT LKKAAVHYDR SGRSLGTADV HFERKADALK AMKQYNGVPL DGRPMNIQLV
       190        200        210        220        230        240
TSQIDTQRRP AQSINRGGMT RNRGSGGFGG GGTRRGTRGG SRGRGRGTGR NSKQQLSAEE
       250
LDAQLDAYNA RMDTS

Isoforms

- Isoform 2 of THO complex subunit 4

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O08583-2-unknown	MADKMD...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
O08583-2-unknown	MADKMD...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O08583-2-Acetylation	ADKMDM...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O08583-2-Acetylation	ADKMDM...	2	acetylation-		N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
O08583-2-Acetylation	ADKMDM...	2	acetylation-		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
O08583-2-Acetylation	ADKMDM...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
O08583-180-unknown	VTSQID...	180		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29478
O08583-180-unknown	VTSQID...	180		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141700

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MNIQLV	179	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29478
...MNIQLV	179	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124882
...RMDTS	255	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RMDTS	255	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87734

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	179	IQLV.\|.VTSQ	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> THOC4_MOUSE @179

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)