O08736: Caspase-12

General Information

Protein names	- Caspase-12 - CASP-12 - 3.4.22.-
Gene names	Casp12
Organism	Mus musculus
Protease Family	C14.013
Protease ID	C14.013
Chromosome location
UniProt ID	O08736

6 N-termini

6 C-termini

5 Cleavages

2 Substrates

Sequence

        10         20         30         40         50         60
MAARRTHERD PIYKIKGLAK DMLDGVFDDL VEKNVLNGDE LLKIGESASF ILNKAENLVE
        70         80         90        100        110        120
NFLEKTDMAG KIFAGHIANS QEQLSLQFSN DEDDGPQKIC TPSSPSESKR KVEDDEMEVN
       130        140        150        160        170        180
AGLAHESHLM LTAPHGLQSS EVQDTLKLCP RDQFCKIKTE RAKEIYPVME KEGRTRLALI
       190        200        210        220        230        240
ICNKKFDYLF DRDNADTDIL NMQELLENLG YSVVLKENLT AQEMETELMQ FAGRPEHQSS
       250        260        270        280        290        300
DSTFLVFMSH GILEGICGVK HRNKKPDVLH DDTIFKIFNN SNCRSLRNKP KILIMQACRG
       310        320        330        340        350        360
RYNGTIWVST NKGIATADTD EERVLSCKWN NSITKAHVET DFIAFKSSTP HNISWKVGKT
       370        380        390        400        410
GSLFISKLID CFKKYCWCYH LEEIFRKVQH SFEVPGELTQ MPTIERVSMT RYFYLFPGN

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 6 C-termini - 5 Cleavages - 2 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O08736-0-unknown	NMAARR...	0	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O08736-95-unknown	GPQKIC...	95	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28531
O08736-133-unknown	APHGLQ...	133	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28315
O08736-159-unknown	TERAKE...	159	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28316
O08736-319-unknown	TDEERV...	319	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28619
O08736-342-unknown	FIAFKS...	342	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28620

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NDEDDG	94	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28531
...HLMLTA	132	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28315
...FCKIKT	158	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28316
...IATADT	318	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28619
...HVETDF	341	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28620
...LFPGN	419	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP7_MOUSE	94	EDDG.\|.GPQK	inferred from experiment	unknown	MEROPS	Bredesen DE	Rao RV et al.:Coupling endoplasmic reticulum ... (C14.004)	11448953,
CAN2_MOUSE	132	MLTA.\|.APHG	inferred from experiment	unknown	MEROPS	Yuan J	Nakagawa T et al.:Cross-talk between two cysteine... (C02.002)	10953012,
CAN2_MOUSE	158	KIKT.\|.TERA	inferred from experiment	unknown	MEROPS	Yuan J	Nakagawa T et al.:Cross-talk between two cysteine... (C02.002)	10953012,
CASPC_MOUSE	318	TADT.\|.TDEE	inferred from experiment	unknown	MEROPS	Momoi T	Fujita E et al.:Caspase-12 processing and fragm... (C14.013)	12232799,
CASPC_MOUSE	341	ETDF.\|.FIAF	inferred from experiment	unknown	MEROPS	Bredesen DE	Rao RV et al.:Coupling endoplasmic reticulum ... (C14.004)	11448953,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASPC_MOUSE	318	TADT.\|.TDEE	inferred from experiment	unknown	MEROPS	Momoi T	Fujita E et al.:Caspase-12 processing and fragm... (C14.013)	12232799,
CASPC_MOUSE	341	ETDF.\|.FIAF	inferred from experiment	unknown	MEROPS	Bredesen DE	Rao RV et al.:Coupling endoplasmic reticulum ... (C14.004)	11448953,