O08784: Treacle protein

General Information

Protein names	- Treacle protein - Treacher Collins syndrome protein homolog
Gene names	Tcof1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	O08784

4 N-termini

6 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAEARKRREL LPLIYHHLLQ AGYVRAAREV KEQSGQKSFL TQPVTLLDIY THWQQTSELG
        70         80         90        100        110        120
QKQKAEDDET LQAKKSRVSD PVSSSESSDQ EKEEEAATER AKATPRPTPV NSATAALPSK
       130        140        150        160        170        180
VKEKGKTKTA NKTVNSVSHP GSGKTVVHLL SGKSPKKSAE PLANTVLASE TEEEGNAQAL
       190        200        210        220        230        240
GPTAKSGTVS AGQGSSSSED SSISSDETDV EVKSPAKPAQ AKASAAPAKD PPARTAPGPT
       250        260        270        280        290        300
KLGNVAPTPA KPARAAAAAA AAAVAAAAAA AAEESESSEE DSDSEDEAPA GLPSQVKASG
       310        320        330        340        350        360
KGPHVRADSV SAKGISGKGP ILATPGKTGP AATQAKAERP EKDSETSSED DSDSEDEMPV
       370        380        390        400        410        420
TVNTPQARTS GKSPRARGTS APAKESSQKG APAVTPGKAR PVAAQAGKPE AKSSEESESD
       430        440        450        460        470        480
SGETPAAATL TTSPAKVKPL GKSSQVRPVS TVTPGSSGKG ANLPCPGKVG SAALRVQMVK
       490        500        510        520        530        540
KEDVSESSSA ELDSDGPGSP AKAKASLALP QKVRPVATQV KTDRGKGHSG SSEESSDSEE
       550        560        570        580        590        600
EAAPAASAAQ AKPALEKQMK ASSRKGTPAS ATGASTSSHC KAGAVTSSAS LSSPALAKGT
       610        620        630        640        650        660
QRSDVDSSSE SESEGAAPST PRVQGKSGGK GLQGKAALGQ GVAPVHTQKT GPSVKAMAQE
       670        680        690        700        710        720
DSESLEEDSS SEEEDETPAQ ATPLGRLPQA KANPPPTKTP PASASGKAVA APTKGKPPVP
       730        740        750        760        770        780
NSTVSARGQR SVPAAGKAGA PATQAQKGPV AGTGEDSESS SKEESDSEEE TPAQIKPVGK
       790        800        810        820        830        840
TSQVRAASAP AKESPKKGAH PGTPGKTGSS ATQAQPGKTE DSDSSSEESD SDTEMPSAQA
       850        860        870        880        890        900
IKSPPVSVNR NSSPAVPAPT PEGVQAVNTT KKASGTTAQS SSSESEDGDE DLIPATQPST
       910        920        930        940        950        960
YALRTSVTTP AALSRAASQP SKSEQSSRMP KGKKAKAAAS AQTSSAVETL PMMPPQSAPI
       970        980        990       1000       1010       1020
QPKATNKLGK SKLPEKQQLA PGYPKAPRSS EDSSDTSSED EEDAKRPQMP KSAHRLDPDP
      1030       1040       1050       1060       1070       1080
SQKETVVEET PTESSEDEMV APSQSLLSGY MTPGLTVANS QASKATPRPD SNSLASSAPA
      1090       1100       1110       1120       1130       1140
TKDNPDGKQK SKSQHAADTA LPKTGRKEAS SGSTPQKPKK LKKSTSSSPA PTQTLPNSIT
      1150       1160       1170       1180       1190       1200
QRLLEQAWPL SEAQVQASVV KVLTELLEQE RLKATEAIKE SGKKSQKRKL SGDLEAGAPK
      1210       1220       1230       1240       1250       1260
NKKKKEQPVP RASAVSPEKA PMTSKAKSKL DKGSAGGKGK GSPGPQGAKE KPDGELLGIK
      1270       1280       1290       1300       1310       1320
LESGEQSDPK SKSKKKKSLK KKKDKEKKEK KKGKKSLAKD SASPIQKKKK KKKKSAEPAV

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

4 N-termini - 6 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O08784-1-unknown	MAEARK...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O08784-592-unknown	SSPALA...	592	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28340
O08784-669-unknown	SSSEEE...	669	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32281
O08784-1178-unknown	IKESGK...	1178	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29486

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ALGPTA	183	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000135295
...SSASLS	591	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28340
...SLEEDS	668	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32281
...ALPKTG	1104	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000134755
...KATEAI	1177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29486
...AEPAV	1320	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_MOUSE	591	ASLS.\|.SSPA	inferred from experiment	unknown	MEROPS	Nunez G	Lamkanfi M et al.:Targeted peptidecentric proteom... (C14.001)	18667412,
GRAB_MOUSE	668	EEDS.\|.SSSE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATE_MOUSE	1177	TEAI.\|.IKES	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TCOF_MOUSE @1177

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)