O14617: AP-3 complex subunit delta-1

General Information

Protein names	- AP-3 complex subunit delta-1 - AP-3 complex subunit delta - Adaptor-related protein complex 3 subunit delta-1 - Delta-adaptin
Gene names	AP3D1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O14617

9 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of AP-3 complex subunit delta-1 - Isoform 3 of AP-3 complex subunit delta-1 - Isoform 4 of AP-3 complex subunit delta-1 - Isoform 5 of AP-3 complex subunit delta-1

Sequence View

        10         20         30         40         50         60
MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD NIAVKANAVC
        70         80         90        100        110        120
KLTYLQMLGY DISWAAFNII EVMSASKFTF KRIGYLAASQ SFHEGTDVIM LTTNQIRKDL
       130        140        150        160        170        180
SSPSQYDTGV ALTGLSCFVT PDLARDLAND IMTLMSHTKP YIRKKAVLIM YKVFLKYPES
       190        200        210        220        230        240
LRPAFPRLKE KLEDPDPGVQ SAAVNVICEL ARRNPKNYLS LAPLFFKLMT SSTNNWVLIK
       250        260        270        280        290        300
IIKLFGALTP LEPRLGKKLI EPLTNLIHST SAMSLLYECV NTVIAVLISL SSGMPNHSAS
       310        320        330        340        350        360
IQLCVQKLRI LIEDSDQNLK YLGLLAMSKI LKTHPKSVQS HKDLILQCLD DKDESIRLRA
       370        380        390        400        410        420
LDLLYGMVSK KNLMEIVKKL MTHVDKAEGT TYRDELLTKI IDICSQSNYQ YITNFEWYIS
       430        440        450        460        470        480
ILVELTRLEG TRHGHLIAAQ MLDVAIRVKA IRKFAVSQMS ALLDSAHLLA SSTQRNGICE
       490        500        510        520        530        540
VLYAAAWICG EFSEHLQEPH HTLEAMLRPR VTTLPGHIQA VYVQNVVKLY ASILQQKEQA
       550        560        570        580        590        600
GEAEGAQAVT QLMVDRLPQF VQSADLEVQE RASCILQLVK HIQKLQAKDV PVAEEVSALF
       610        620        630        640        650        660
AGELNPVAPK AQKKVPVPEG LDLDAWINEP LSDSESEDER PRAVFHEEEQ RRPKHRPSEA
       670        680        690        700        710        720
DEEELARRRE ARKQEQANNP FYIKSSPSPQ KRYQDTPGVE HIPVVQIDLS VPLKVPGLPM
       730        740        750        760        770        780
SDQYVKLEEE RRHRQKLEKD KRRKKRKEKE KKGKRRHSSL PTESDEDIAP AQQVDIVTEE
       790        800        810        820        830        840
MPENALPSDE DDKDPNDPYR ALDIDLDKPL ADSEKLPIQK HRNTETSKSP EKDVPMVEKK
       850        860        870        880        890        900
SKKPKKKEKK HKEKERDKEK KKEKEKKKSP KPKKKKHRKE KEERTKGKKK SKKQPPGSEE
       910        920        930        940        950        960
AAGEPVQNGA PEEEQLPPES SYSLLAENSY VKMTCDIRGS LQEDSQVTVA IVLENRSSSI
       970        980        990       1000       1010       1020
LKGMELSVLD SLNARMARPQ GSSVHDGVPV PFQLPPGVSN EAQYVFTIQS IVMAQKLKGT
      1030       1040       1050       1060       1070       1080
LSFIAKNDEG ATHEKLDFRL HFSCSSYLIT TPCYSDAFAK LLESGDLSMS SIKVDGIRMS
      1090       1100       1110       1120       1130       1140
FQNLLAKICF HHHFSVVERV DSCASMYSRS IQGHHVCLLV KKGENSVSVD GKCSDSTLLS
      1150
NLLEEMKATL AKC         10         20         30         40         50         60
MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD NIAVKANAVC
        70         80         90        100        110        120
KLTYLQMLGY DISWAAFNII EVMSASKFTF KRIGYLAASQ SFHEGTDVIM LTTNQIRKDL
       130        140        150        160        170        180
SSPSQYDTGV ALTGLSCFVT PDLARDLAND IMTLMSHTKP YIRKKAVLIM YKVFLKYPES
       190        200        210        220        230        240
LRPAFPRLKE KLEDPDPGVQ SAAVNVICEL ARRNPKNYLS LAPLFFKLMT SSTNNWVLIK
       250        260        270        280        290        300
IIKLFGALTP LEPRLGKKLI EPLTNLIHST SAMSLLYECV NTVIAVLISL SSGMPNHSAS
       310        320        330        340        350        360
IQLCVQKLRI LIEDSDQNLK YLGLLAMSKI LKTHPKSVQS HKDLILQCLD DKDESIRLRA
       370        380        390        400        410        420
LDLLYGMVSK KNLMEIVKKL MTHVDKAEGT TYRDELLTKI IDICSQSNYQ YITNFEWYIS
       430        440        450        460        470        480
ILVELTRLEG TRHGHLIAAQ MLDVAIRVKA IRKFAVSQMS ALLDSAHLLA SSTQRNGICE
       490        500        510        520        530        540
VLYAAAWICG EFSEHLQEPH HTLEAMLRPR VTTLPGHIQA VYVQNVVKLY ASILQQKEQA
       550        560        570        580        590        600
GEAEGAQAVT QLMVDRLPQF VQSADLEVQE RASCILQLVK HIQKLQAKDV PVAEEVSALF
       610        620        630        640        650        660
AGELNPVAPK AQKKVPVPEG LDLDAWINEP LSDSESEDER PRAVFHEEEQ RRPKHRPSEA
       670        680        690        700        710        720
DEEELARRRE ARKQEQANNP FYIKSSPSPQ KRYQDTPGVE HIPVVQIDLS VPLKVPGLPM
       730        740        750        760        770        780
SDQYVKLEEE RRHRQKLEKD KRRKKRKEKE KKGKRRHSSL PTESDEDIAP AQQVDIVTEE
       790        800        810        820        830        840
MPENALPSDE DDKDPNDPYR ALDIDLDKPL ADSEKLPIQK HRNTETSKSP EKDVPMVEKK
       850        860        870        880        890        900
SKKPKKKEKK HKEKERDKEK KKEKEKKKSP KPKKKKHRKE KEERTKGKKK SKKQPPGSEE
       910        920        930        940        950        960
AAGEPVQNGA PEEEQLPPES SYSLLAENSY VKMTCDIRGS LQEDSQVTVA IVLENRSSSI
       970        980        990       1000       1010       1020
LKGMELSVLD SLNARMARPQ GSSVHDGVPV PFQLPPGVSN EAQYVFTIQS IVMAQKLKGT
      1030       1040       1050       1060       1070       1080
LSFIAKNDEG ATHEKLDFRL HFSCSSYLIT TPCYSDAFAK LLESGDLSMS SIKVDGIRMS
      1090       1100       1110       1120       1130       1140
FQNLLAKICF HHHFSVVERV DSCASMYSRS IQGHHVCLLV KKGENSVSVD GKCSDSTLLS
      1150
NLLEEMKATL AKC         10         20         30         40         50         60
MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD NIAVKANAVC
        70         80         90        100        110        120
KLTYLQMLGY DISWAAFNII EVMSASKFTF KRIGYLAASQ SFHEGTDVIM LTTNQIRKDL
       130        140        150        160        170        180
SSPSQYDTGV ALTGLSCFVT PDLARDLAND IMTLMSHTKP YIRKKAVLIM YKVFLKYPES
       190        200        210        220        230        240
LRPAFPRLKE KLEDPDPGVQ SAAVNVICEL ARRNPKNYLS LAPLFFKLMT SSTNNWVLIK
       250        260        270        280        290        300
IIKLFGALTP LEPRLGKKLI EPLTNLIHST SAMSLLYECV NTVIAVLISL SSGMPNHSAS
       310        320        330        340        350        360
IQLCVQKLRI LIEDSDQNLK YLGLLAMSKI LKTHPKSVQS HKDLILQCLD DKDESIRLRA
       370        380        390        400        410        420
LDLLYGMVSK KNLMEIVKKL MTHVDKAEGT TYRDELLTKI IDICSQSNYQ YITNFEWYIS
       430        440        450        460        470        480
ILVELTRLEG TRHGHLIAAQ MLDVAIRVKA IRKFAVSQMS ALLDSAHLLA SSTQRNGICE
       490        500        510        520        530        540
VLYAAAWICG EFSEHLQEPH HTLEAMLRPR VTTLPGHIQA VYVQNVVKLY ASILQQKEQA
       550        560        570        580        590        600
GEAEGAQAVT QLMVDRLPQF VQSADLEVQE RASCILQLVK HIQKLQAKDV PVAEEVSALF
       610        620        630        640        650        660
AGELNPVAPK AQKKVPVPEG LDLDAWINEP LSDSESEDER PRAVFHEEEQ RRPKHRPSEA
       670        680        690        700        710        720
DEEELARRRE ARKQEQANNP FYIKSSPSPQ KRYQDTPGVE HIPVVQIDLS VPLKVPGLPM
       730        740        750        760        770        780
SDQYVKLEEE RRHRQKLEKD KRRKKRKEKE KKGKRRHSSL PTESDEDIAP AQQVDIVTEE
       790        800        810        820        830        840
MPENALPSDE DDKDPNDPYR ALDIDLDKPL ADSEKLPIQK HRNTETSKSP EKDVPMVEKK
       850        860        870        880        890        900
SKKPKKKEKK HKEKERDKEK KKEKEKKKSP KPKKKKHRKE KEERTKGKKK SKKQPPGSEE
       910        920        930        940        950        960
AAGEPVQNGA PEEEQLPPES SYSLLAENSY VKMTCDIRGS LQEDSQVTVA IVLENRSSSI
       970        980        990       1000       1010       1020
LKGMELSVLD SLNARMARPQ GSSVHDGVPV PFQLPPGVSN EAQYVFTIQS IVMAQKLKGT
      1030       1040       1050       1060       1070       1080
LSFIAKNDEG ATHEKLDFRL HFSCSSYLIT TPCYSDAFAK LLESGDLSMS SIKVDGIRMS
      1090       1100       1110       1120       1130       1140
FQNLLAKICF HHHFSVVERV DSCASMYSRS IQGHHVCLLV KKGENSVSVD GKCSDSTLLS
      1150
NLLEEMKATL AKC         10         20         30         40         50         60
MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD NIAVKANAVC
        70         80         90        100        110        120
KLTYLQMLGY DISWAAFNII EVMSASKFTF KRIGYLAASQ SFHEGTDVIM LTTNQIRKDL
       130        140        150        160        170        180
SSPSQYDTGV ALTGLSCFVT PDLARDLAND IMTLMSHTKP YIRKKAVLIM YKVFLKYPES
       190        200        210        220        230        240
LRPAFPRLKE KLEDPDPGVQ SAAVNVICEL ARRNPKNYLS LAPLFFKLMT SSTNNWVLIK
       250        260        270        280        290        300
IIKLFGALTP LEPRLGKKLI EPLTNLIHST SAMSLLYECV NTVIAVLISL SSGMPNHSAS
       310        320        330        340        350        360
IQLCVQKLRI LIEDSDQNLK YLGLLAMSKI LKTHPKSVQS HKDLILQCLD DKDESIRLRA
       370        380        390        400        410        420
LDLLYGMVSK KNLMEIVKKL MTHVDKAEGT TYRDELLTKI IDICSQSNYQ YITNFEWYIS
       430        440        450        460        470        480
ILVELTRLEG TRHGHLIAAQ MLDVAIRVKA IRKFAVSQMS ALLDSAHLLA SSTQRNGICE
       490        500        510        520        530        540
VLYAAAWICG EFSEHLQEPH HTLEAMLRPR VTTLPGHIQA VYVQNVVKLY ASILQQKEQA
       550        560        570        580        590        600
GEAEGAQAVT QLMVDRLPQF VQSADLEVQE RASCILQLVK HIQKLQAKDV PVAEEVSALF
       610        620        630        640        650        660
AGELNPVAPK AQKKVPVPEG LDLDAWINEP LSDSESEDER PRAVFHEEEQ RRPKHRPSEA
       670        680        690        700        710        720
DEEELARRRE ARKQEQANNP FYIKSSPSPQ KRYQDTPGVE HIPVVQIDLS VPLKVPGLPM
       730        740        750        760        770        780
SDQYVKLEEE RRHRQKLEKD KRRKKRKEKE KKGKRRHSSL PTESDEDIAP AQQVDIVTEE
       790        800        810        820        830        840
MPENALPSDE DDKDPNDPYR ALDIDLDKPL ADSEKLPIQK HRNTETSKSP EKDVPMVEKK
       850        860        870        880        890        900
SKKPKKKEKK HKEKERDKEK KKEKEKKKSP KPKKKKHRKE KEERTKGKKK SKKQPPGSEE
       910        920        930        940        950        960
AAGEPVQNGA PEEEQLPPES SYSLLAENSY VKMTCDIRGS LQEDSQVTVA IVLENRSSSI
       970        980        990       1000       1010       1020
LKGMELSVLD SLNARMARPQ GSSVHDGVPV PFQLPPGVSN EAQYVFTIQS IVMAQKLKGT
      1030       1040       1050       1060       1070       1080
LSFIAKNDEG ATHEKLDFRL HFSCSSYLIT TPCYSDAFAK LLESGDLSMS SIKVDGIRMS
      1090       1100       1110       1120       1130       1140
FQNLLAKICF HHHFSVVERV DSCASMYSRS IQGHHVCLLV KKGENSVSVD GKCSDSTLLS
      1150
NLLEEMKATL AKC

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O14617-2-unknown	MALKMV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14617-1-unknown	MALKMV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67159
O14617-1-unknown	MALKMV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67160
O14617-1-unknown	MALKMV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67161
O14617-1-unknown	MALKMV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67162
O14617-2-Acetylation	ALKMVK...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14617-2-Acetylation	ALKMVK...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O14617-2-Acetylation	ALKMVK...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O14617-2-Acetylation	ALKMVK...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110013
O14617-2-Acetylation	ALKMVK...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110014
O14617-2-Acetylation	ALKMVK...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110015
O14617-2-Acetylation	ALKMVK...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110016
O14617-64-unknown	YLQMLG...	64		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
O14617-64-unknown	YLQMLG...	64		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196376
O14617-64-unknown	YLQMLG...	64		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196377
O14617-64-unknown	YLQMLG...	64		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196378
O14617-64-unknown	YLQMLG...	64		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196379
O14617-709-unknown	LSVPLK...	709		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10668
O14617-709-unknown	LSVPLK...	709		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153873
O14617-709-unknown	LSVPLK...	709		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154893
O14617-709-unknown	LSVPLK...	709		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155940
O14617-709-unknown	LSVPLK...	709		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155941
O14617-709-	LSVPLK...	709			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O14617-710-	SVPLKV...	710			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O14617-710-	SVPLKV...	710			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
O14617-710-	SVPLKV...	710			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O14617-710-	SVPLKV...	710			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O14617-710-	SVPLKV...	710			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
O14617-710-unknown	SVPLKV...	710		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165674
O14617-710-unknown	SVPLKV...	710		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165675
O14617-710-unknown	SVPLKV...	710		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165672
O14617-710-unknown	SVPLKV...	710		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165673
O14617-723-unknown	QYVKLE...	723		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10673
O14617-723-unknown	QYVKLE...	723		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154030
O14617-723-unknown	QYVKLE...	723		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155100
O14617-723-unknown	QYVKLE...	723		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156095
O14617-723-unknown	QYVKLE...	723		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156096

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VVQIDL	708	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10668
...VVQIDL	708	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137295
...VVQIDL	708	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138320
...VVQIDL	708	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139397
...VVQIDL	708	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139398
...LPMSDQ	722	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10673
...LPMSDQ	722	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137449
...LPMSDQ	722	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138527
...LPMSDQ	722	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139558
...LPMSDQ	722	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139559
...TLAKC	1153	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TLAKC	1153	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62778
...TLAKC	1153	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62779
...TLAKC	1153	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62777
...TLAKC	1153	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62780

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	708	QIDL.\|.LSVP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	722	MSDQ.\|.QYVK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)