O15047: Histone-lysine N-methyltransferase SETD1A

General Information

Protein names	- Histone-lysine N-methyltransferase SETD1A - 2.1.1.43 - Lysine N-methyltransferase 2F - SET domain-containing protein 1A - hSET1A - Set1/Ash2 histone methyltransferase complex subunit SET1
Gene names	SETD1A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O15047

3 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDQEGGGDGQ KAPSFQWRNY KLIVDPALDP ALRRPSQKVY RYDGVHFSVN DSKYIPVEDL
        70         80         90        100        110        120
QDPRCHVRSK NRDFSLPVPK FKLDEFYIGQ IPLKEVTFAR LNDNVRETFL KDMCRKYGEV
       130        140        150        160        170        180
EEVEILLHPR TRKHLGLARV LFTSTRGAKE TVKNLHLTSV MGNIIHAQLD IKGQQRMKYY
       190        200        210        220        230        240
ELIVNGSYTP QTVPTGGKAL SEKFQGSGAA TETAESRRRS SSDTAAYPAG TTAVGTPGNG
       250        260        270        280        290        300
TPCSQDTSFS SSRQDTPSSF GQFTPQSSQG TPYTSRGSTP YSQDSAYSSS TTSTSFKPRR
       310        320        330        340        350        360
SENSYQDAFS RRHFSASSAS TTASTAIAAT TAATASSSAS SSSLSSSSSS SSSSSSSQFR
       370        380        390        400        410        420
SSDANYPAYY ESWNRYQRHT SYPPRRATRE EPPGAPFAEN TAERFPPSYT SYLPPEPSRP
       430        440        450        460        470        480
TDQDYRPPAS EAPPPEPPEP GGGGGGGGPS PEREEVRTSP RPASPARSGS PAPETTNESV
       490        500        510        520        530        540
PFAQHSSLDS RIEMLLKEQR SKFSFLASDT EEEEENSSMV LGARDTGSEV PSGSGHGPCT
       550        560        570        580        590        600
PPPAPANFED VAPTGSGEPG ATRESPKANG QNQASPCSSG DDMEISDDDR GGSPPPAPTP
       610        620        630        640        650        660
PQQPPPPPPP PPPPPPYLAS LPLGYPPHQP AYLLPPRPDG PPPPEYPPPP PPPPHIYDFV
       670        680        690        700        710        720
NSLELMDRLG AQWGGMPMSF QMQTQMLTRL HQLRQGKGLI AASAGPPGGA FGEAFLPFPP
       730        740        750        760        770        780
PQEAAYGLPY ALYAQGQEGR GAYSREAYHL PMPMAAEPLP SSSVSGEEAR LPPREEAELA
       790        800        810        820        830        840
EGKTLPTAGT VGRVLAMLVQ EMKSIMQRDL NRKMVENVAF GAFDQWWESK EEKAKPFQNA
       850        860        870        880        890        900
AKQQAKEEDK EKTKLKEPGL LSLVDWAKSG GTTGIEAFAF GSGLRGALRL PSFKVKRKEP
       910        920        930        940        950        960
SEISEASEEK RPRPSTPAEE DEDDPEQEKE AGEPGRPGTK PPKRDEERGK TQGKHRKSFA
       970        980        990       1000       1010       1020
LDSEGEEASQ ESSSEKDEED DEEDEEDEDR EEAVDTTKKE TEVSDGEDEE SDSSSKCSLY
      1030       1040       1050       1060       1070       1080
ADSDGENDST SDSESSSSSS SSSSSSSSSS SSSSSSSSES SSEDEEEEER PAALPSASPP
      1090       1100       1110       1120       1130       1140
PREVPVPTPA PVEVPVPERV AGSPVTPLPE QEASPARPAG PTEESPPSAP LRPPEPPAGP
      1150       1160       1170       1180       1190       1200
PAPAPRPDER PSSPIPLLPP PKKRRKTVSF SAIEVVPAPE PPPATPPQAK FPGPASRKAP
      1210       1220       1230       1240       1250       1260
RGVERTIRNL PLDHASLVKS WPEEVSRGGR SRAGGRGRLT EEEEAEPGTE VDLAVLADLA
      1270       1280       1290       1300       1310       1320
LTPARRGLPA LPAVEDSEAT ETSDEAERPR PLLSHILLEH NYALAVKPTP PAPALRPPEP
      1330       1340       1350       1360       1370       1380
VPAPAALFSS PADEVLEAPE VVVAEAEEPK PQQLQQQREE GEEEGEEEGE EEEEESSDSS
      1390       1400       1410       1420       1430       1440
SSSDGEGALR RRSLRSHARR RRPPPPPPPP PPRAYEPRSE FEQMTILYDI WNSGLDSEDM
      1450       1460       1470       1480       1490       1500
SYLRLTYERL LQQTSGADWL NDTHWVHHTI TNLTTPKRKR RPQDGPREHQ TGSARSEGYY
      1510       1520       1530       1540       1550       1560
PISKKEKDKY LDVCPVSARQ LEGVDTQGTN RVLSERRSEQ RRLLSAIGTS AIMDSDLLKL
      1570       1580       1590       1600       1610       1620
NQLKFRKKKL RFGRSRIHEW GLFAMEPIAA DEMVIEYVGQ NIRQMVADMR EKRYVQEGIG
      1630       1640       1650       1660       1670       1680
SSYLFRVDHD TIIDATKCGN LARFINHCCT PNCYAKVITI ESQKKIVIYS KQPIGVDEEI
      1690       1700
TYDYKFPLED NKIPCLCGTE SCRGSLN

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O15047-1-unknown	MDQEGG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O15047-1253-unknown	LAVLAD...	1253	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10700
O15047-1254-	AVLADL...	1254		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O15047-1254-	AVLADL...	1254		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O15047-1254-	AVLADL...	1254		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CSQDTS	247	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000391408
...GTEVDL	1252	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10700
...RGSLN	1707	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	1252	EVDL.\|.LAVL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)