O15144: Actin-related protein 2/3 complex subunit 2

General Information

Protein names	- Actin-related protein 2/3 complex subunit 2 - Arp2/3 complex 34 kDa subunit - p34-ARC
Gene names	ARPC2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O15144

5 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MILLEVNNRI IEETLALKFE NAAAGNKPEA VEVTFADFDG VLYHISNPNG DKTKVMVSIS
        70         80         90        100        110        120
LKFYKELQAH GADELLKRVY GSFLVNPESG YNVSLLYDLE NLPASKDSIV HQAGMLKRNC
       130        140        150        160        170        180
FASVFEKYFQ FQEEGKEGEN RAVIHYRDDE TMYVESKKDR VTVVFSTVFK DDDDVVIGKV
       190        200        210        220        230        240
FMQEFKEGRR ASHTAPQVLF SHREPPLELK DTDAAVGDNI GYITFVLFPR HTNASARDNT
       250        260        270        280        290        300
INLIHTFRDY LHYHIKCSKA YIHTRMRAKT SDFLKVLNRA RPDAEKKEMK TITGKTFSSR

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O15144-1-unknown	MILLEV...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O15144-1-unknown	MILLEV...	1		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O15144-1-unknown	MILLEV...	1		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O15144-1-	MILLEV...	1		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O15144-1-	MILLEV...	1		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O15144-1-	MILLEV...	1		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O15144-1-	MILLEV...	1		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O15144-1-	MILLEV...	1		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O15144-69-unknown	AHGADE...	69	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7013
O15144-186-unknown	KEGRRA...	186	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000411612
O15144-291-	TITGKT...	291		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O15144-291-	TITGKT...	291		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YKELQA	68	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7013
...VNPESG	89	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000401070
...TFSSR	300	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	68	ELQA.\|.AHGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)