O15213: WD repeat-containing protein 46

General Information

Protein names	- WD repeat-containing protein 46 - WD repeat-containing protein BING4
Gene names	WDR46
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O15213

5 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
METAPKPGKD VPPKKDKLQT KRKKPRRYWE EETVPTTAGA SPGPPRNKKN RELRPQRPKN
        70         80         90        100        110        120
AYILKKSRIS KKPQVPKKPR EWKNPESQRG LSGTQDPFPG PAPVPVEVVQ KFCRIDKSRK
       130        140        150        160        170        180
LPHSKAKTRS RLEVAEAEEE ETSIKAARSE LLLAEEPGFL EGEDGEDTAK ICQADIVEAV
       190        200        210        220        230        240
DIASAAKHFD LNLRQFGPYR LNYSRTGRHL AFGGRRGHVA ALDWVTKKLM CEINVMEAVR
       250        260        270        280        290        300
DIRFLHSEAL LAVAQNRWLH IYDNQGIELH CIRRCDRVTR LEFLPFHFLL ATASETGFLT
       310        320        330        340        350        360
YLDVSVGKIV AALNARAGRL DVMSQNPYNA VIHLGHSNGT VSLWSPAMKE PLAKILCHRG
       370        380        390        400        410        420
GVRAVAVDST GTYMATSGLD HQLKIFDLRG TYQPLSTRTL PHGAGHLAFS QRGLLVAGMG
       430        440        450        460        470        480
DVVNIWAGQG KASPPSLEQP YLTHRLSGPV HGLQFCPFED VLGVGHTGGI TSMLVPGAGE
       490        500        510        520        530        540
PNFDGLESNP YRSRKQRQEW EVKALLEKVP AELICLDPRA LAEVDVISLE QGKKEQIERL
       550        560        570        580        590        600
GYDPQAKAPF QPKPKQKGRS STASLVKRKR KVMDEEHRDK VRQSLQQQHH KEAKAKPTGA
       610
RPSALDRFVR

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O15213-1-acetylation	METAPK...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O15213-1-unknown	METAPK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O15213-66-unknown	KSRISK...	66		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000412069
O15213-66-unknown	KSRISK...	66		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000405568
O15213-66-unknown	KSRISK...	66		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000408651
O15213-66-unknown	KSRISK...	66		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000406835
O15213-66-unknown	KSRISK...	66		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000407066
O15213-520-unknown	ALAEVD...	520		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9878
O15213-526-unknown	VISLEQ...	526		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10705

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TYQPLS	395	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000412069
...TYQPLS	395	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405568
...TYQPLS	395	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000408651
...TYQPLS	395	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000406835
...TYQPLS	395	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000407066
...CLDPRA	519	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9878
...LAEVDV	525	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10705
...DRFVR	610	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	519	DPRA.\|.ALAE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	525	EVDV.\|.VISL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)