O15530: 3-phosphoinositide-dependent protein kinase 1

General Information

Protein names	- 3-phosphoinositide-dependent protein kinase 1 - hPDK1 - 2.7.11.1
Gene names	PDPK1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O15530

6 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of 3-phosphoinositide-dependent protein kinase 1 - Isoform 3 of 3-phosphoinositide-dependent protein kinase 1 - Isoform 4 of 3-phosphoinositide-dependent protein kinase 1 - Isoform 5 of 3-phosphoinositide-dependent protein kinase 1

Sequence View

        10         20         30         40         50         60
MARTTSQLYD AVPIQSSVVL CSCPSPSMVR TQTESSTPPG IPGGSRQGPA MDGTAAEPRP
        70         80         90        100        110        120
GAGSLQHAQP PPQPRKKRPE DFKFGKILGE GSFSTVVLAR ELATSREYAI KILEKRHIIK
       130        140        150        160        170        180
ENKVPYVTRE RDVMSRLDHP FFVKLYFTFQ DDEKLYFGLS YAKNGELLKY IRKIGSFDET
       190        200        210        220        230        240
CTRFYTAEIV SALEYLHGKG IIHRDLKPEN ILLNEDMHIQ ITDFGTAKVL SPESKQARAN
       250        260        270        280        290        300
SFVGTAQYVS PELLTEKSAC KSSDLWALGC IIYQLVAGLP PFRAGNEYLI FQKIIKLEYD
       310        320        330        340        350        360
FPEKFFPKAR DLVEKLLVLD ATKRLGCEEM EGYGPLKAHP FFESVTWENL HQQTPPKLTA
       370        380        390        400        410        420
YLPAMSEDDE DCYGNYDNLL SQFGCMQVSS SSSSHSLSAS DTGLPQRSGS NIEQYIHDLD
       430        440        450        460        470        480
SNSFELDLQF SEDEKRLLLE KQAGGNPWHQ FVENNLILKM GPVDKRKGLF ARRRQLLLTE
       490        500        510        520        530        540
GPHLYYVDPV NKVLKGEIPW SQELRPEAKN FKTFFVHTPN RTYYLMDPSG NAHKWCRKIQ
       550
EVWRQRYQSH PDAAVQ         10         20         30         40         50         60
MARTTSQLYD AVPIQSSVVL CSCPSPSMVR TQTESSTPPG IPGGSRQGPA MDGTAAEPRP
        70         80         90        100        110        120
GAGSLQHAQP PPQPRKKRPE DFKFGKILGE GSFSTVVLAR ELATSREYAI KILEKRHIIK
       130        140        150        160        170        180
ENKVPYVTRE RDVMSRLDHP FFVKLYFTFQ DDEKLYFGLS YAKNGELLKY IRKIGSFDET
       190        200        210        220        230        240
CTRFYTAEIV SALEYLHGKG IIHRDLKPEN ILLNEDMHIQ ITDFGTAKVL SPESKQARAN
       250        260        270        280        290        300
SFVGTAQYVS PELLTEKSAC KSSDLWALGC IIYQLVAGLP PFRAGNEYLI FQKIIKLEYD
       310        320        330        340        350        360
FPEKFFPKAR DLVEKLLVLD ATKRLGCEEM EGYGPLKAHP FFESVTWENL HQQTPPKLTA
       370        380        390        400        410        420
YLPAMSEDDE DCYGNYDNLL SQFGCMQVSS SSSSHSLSAS DTGLPQRSGS NIEQYIHDLD
       430        440        450        460        470        480
SNSFELDLQF SEDEKRLLLE KQAGGNPWHQ FVENNLILKM GPVDKRKGLF ARRRQLLLTE
       490        500        510        520        530        540
GPHLYYVDPV NKVLKGEIPW SQELRPEAKN FKTFFVHTPN RTYYLMDPSG NAHKWCRKIQ
       550
EVWRQRYQSH PDAAVQ         10         20         30         40         50         60
MARTTSQLYD AVPIQSSVVL CSCPSPSMVR TQTESSTPPG IPGGSRQGPA MDGTAAEPRP
        70         80         90        100        110        120
GAGSLQHAQP PPQPRKKRPE DFKFGKILGE GSFSTVVLAR ELATSREYAI KILEKRHIIK
       130        140        150        160        170        180
ENKVPYVTRE RDVMSRLDHP FFVKLYFTFQ DDEKLYFGLS YAKNGELLKY IRKIGSFDET
       190        200        210        220        230        240
CTRFYTAEIV SALEYLHGKG IIHRDLKPEN ILLNEDMHIQ ITDFGTAKVL SPESKQARAN
       250        260        270        280        290        300
SFVGTAQYVS PELLTEKSAC KSSDLWALGC IIYQLVAGLP PFRAGNEYLI FQKIIKLEYD
       310        320        330        340        350        360
FPEKFFPKAR DLVEKLLVLD ATKRLGCEEM EGYGPLKAHP FFESVTWENL HQQTPPKLTA
       370        380        390        400        410        420
YLPAMSEDDE DCYGNYDNLL SQFGCMQVSS SSSSHSLSAS DTGLPQRSGS NIEQYIHDLD
       430        440        450        460        470        480
SNSFELDLQF SEDEKRLLLE KQAGGNPWHQ FVENNLILKM GPVDKRKGLF ARRRQLLLTE
       490        500        510        520        530        540
GPHLYYVDPV NKVLKGEIPW SQELRPEAKN FKTFFVHTPN RTYYLMDPSG NAHKWCRKIQ
       550
EVWRQRYQSH PDAAVQ         10         20         30         40         50         60
MARTTSQLYD AVPIQSSVVL CSCPSPSMVR TQTESSTPPG IPGGSRQGPA MDGTAAEPRP
        70         80         90        100        110        120
GAGSLQHAQP PPQPRKKRPE DFKFGKILGE GSFSTVVLAR ELATSREYAI KILEKRHIIK
       130        140        150        160        170        180
ENKVPYVTRE RDVMSRLDHP FFVKLYFTFQ DDEKLYFGLS YAKNGELLKY IRKIGSFDET
       190        200        210        220        230        240
CTRFYTAEIV SALEYLHGKG IIHRDLKPEN ILLNEDMHIQ ITDFGTAKVL SPESKQARAN
       250        260        270        280        290        300
SFVGTAQYVS PELLTEKSAC KSSDLWALGC IIYQLVAGLP PFRAGNEYLI FQKIIKLEYD
       310        320        330        340        350        360
FPEKFFPKAR DLVEKLLVLD ATKRLGCEEM EGYGPLKAHP FFESVTWENL HQQTPPKLTA
       370        380        390        400        410        420
YLPAMSEDDE DCYGNYDNLL SQFGCMQVSS SSSSHSLSAS DTGLPQRSGS NIEQYIHDLD
       430        440        450        460        470        480
SNSFELDLQF SEDEKRLLLE KQAGGNPWHQ FVENNLILKM GPVDKRKGLF ARRRQLLLTE
       490        500        510        520        530        540
GPHLYYVDPV NKVLKGEIPW SQELRPEAKN FKTFFVHTPN RTYYLMDPSG NAHKWCRKIQ
       550
EVWRQRYQSH PDAAVQ

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O15530-1-unknown	MARTTS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O15530-1-unknown	MARTTS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84775
O15530-1-unknown	MARTTS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84776
O15530-1-unknown	MARTTS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84777
O15530-51-unknown	MDGTAA...	51	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84774
O15530-51-unknown	MDGTAA...	51	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98025
O15530-51-unknown	MDGTAA...	51	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98026
O15530-51-unknown	MDGTAA...	51	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98027
O15530-53-unknown	GTAAEP...	53	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174304
O15530-53-unknown	GTAAEP...	53	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174301
O15530-53-unknown	GTAAEP...	53	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174302
O15530-53-unknown	GTAAEP...	53	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174303
O15530-53-	GTAAEP...	53		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O15530-53-	GTAAEP...	53		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O15530-398-	SASDTG...	398		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O15530-398-unknown	SASDTG...	398	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168620
O15530-398-unknown	SASDTG...	398	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168622
O15530-398-unknown	SASDTG...	398	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168621
O15530-398-unknown	SASDTG...	398	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168619

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DAAVQ	556	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DAAVQ	556	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80394
...DAAVQ	556	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80392
...DAAVQ	556	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80393

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)