O43172: U4/U6 small nuclear ribonucleoprotein Prp4

General Information

Protein names	- U4/U6 small nuclear ribonucleoprotein Prp4 - PRP4 homolog - hPrp4 - U4/U6 snRNP 60 kDa protein - WD splicing factor Prp4
Gene names	PRPF4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43172

3 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASSRASSTQ ATKTKAPDDL VAPVVKKPHI YYGSLEEKER ERLAKGESGI LGKDGLKAGI
        70         80         90        100        110        120
EAGNINITSG EVFEIEEHIS ERQAEVLAEF ERRKRARQIN VSTDDSEVKA CLRALGEPIT
       130        140        150        160        170        180
LFGEGPAERR ERLRNILSVV GTDALKKTKK DDEKSKKSKE EYQQTWYHEG PNSLKVARLW
       190        200        210        220        230        240
IANYSLPRAM KRLEEARLHK EIPETTRTSQ MQELHKSLRS LNNFCSQIGD DRPISYCHFS
       250        260        270        280        290        300
PNSKMLATAC WSGLCKLWSV PDCNLLHTLR GHNTNVGAIV FHPKSTVSLD PKDVNLASCA
       310        320        330        340        350        360
ADGSVKLWSL DSDEPVADIE GHTVRVARVM WHPSGRFLGT TCYDRSWRLW DLEAQEEILH
       370        380        390        400        410        420
QEGHSMGVYD IAFHQDGSLA GTGGLDAFGR VWDLRTGRCI MFLEGHLKEI YGINFSPNGY
       430        440        450        460        470        480
HIATGSGDNT CKVWDLRQRR CVYTIPAHQN LVTGVKFEPI HGNFLLTGAY DNTAKIWTHP
       490        500        510        520
GWSPLKTLAG HEGKVMGLDI SSDGQLIATC SYDRTFKLWM AE

Isoforms

- Isoform 2 of U4/U6 small nuclear ribonucleoprotein Prp4

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O43172-1-unknown	MASSRA...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O43172-144-unknown	ALKKTK...	144	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10724
O43172-144-unknown	ALKKTK...	144	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144463
O43172-381-unknown	GTGGLD...	381	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7016
O43172-381-unknown	GTGGLD...	381	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151609

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...VVGTDA	143	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10724
...VVGTDA	143	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt127727
...DGSLAG	380	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7016
...DGSLAG	380	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt135016
...LWMAE	522	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...LWMAE	522	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt81891
...LWMAE	522		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...LWMAE	522		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	143	GTDA.\|.ALKK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATS_HUMAN	380	SLAG.\|.GTGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)