O43395: U4/U6 small nuclear ribonucleoprotein Prp3

General Information

Protein names	- U4/U6 small nuclear ribonucleoprotein Prp3 - Pre-mRNA-splicing factor 3 - hPrp3 - U4/U6 snRNP 90 kDa protein
Gene names	PRPF3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43395

6 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MALSKRELDE LKPWIEKTVK RVLGFSEPTV VTAALNCVGK GMDKKKAADH LKPFLDDSTL
        70         80         90        100        110        120
RFVDKLFEAV EEGRSSRHSK SSSDRSRKRE LKEVFGDDSE ISKESSGVKK RRIPRFEEVE
       130        140        150        160        170        180
EEPEVIPGPP SESPGMLTKL QIKQMMEAAT RQIEERKKQL SFISPPTPQP KTPSSSQPER
       190        200        210        220        230        240
LPIGNTIQPS QAATFMNDAI EKARKAAELQ ARIQAQLALK PGLIGNANMV GLANLHAMGI
       250        260        270        280        290        300
APPKVELKDQ TKPTPLILDE QGRTVDATGK EIELTHRMPT LKANIRAVKR EQFKQQLKEK
       310        320        330        340        350        360
PSEDMESNTF FDPRVSIAPS QRQRRTFKFH DKGKFEKIAQ RLRTKAQLEK LQAEISQAAR
       370        380        390        400        410        420
KTGIHTSTRL ALIAPKKELK EGDIPEIEWW DSYIIPNGFD LTEENPKRED YFGITNLVEH
       430        440        450        460        470        480
PAQLNPPVDN DTPVTLGVYL TKKEQKKLRR QTRREAQKEL QEKVRLGLMP PPEPKVRISN
       490        500        510        520        530        540
LMRVLGTEAV QDPTKVEAHV RAQMAKRQKA HEEANAARKL TAEQRKVKKI KKLKEDISQG
       550        560        570        580        590        600
VHISVYRVRN LSNPAKKFKI EANAGQLYLT GVVVLHKDVN VVVVEGGPKA QKKFKRLMLH
       610        620        630        640        650        660
RIKWDEQTSN TKGDDDEESD EEAVKKTNKC VLVWEGTAKD RSFGEMKFKQ CPTENMAREH
       670        680
FKKHGAEHYW DLALSESVLE STD

Isoforms

- Isoform 2 of U4/U6 small nuclear ribonucleoprotein Prp3

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O43395-1-unknown	MALSKR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43395-98-unknown	DSEISK...	98	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10751
O43395-99-unknown	SEISKE...	99	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10752
O43395-136-unknown	MLTKLQ...	136	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463756
O43395-136-unknown	MLTKLQ...	136	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000445421
O43395-231-	GLANLH...	231		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
O43395-486-unknown	GTEAVQ...	486	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13751

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EVFGDD	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10751
...VFGDDS	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10752
...LMRVLG	485	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13751
...LESTD	683	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	97	FGDD.\|.DSEI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	98	GDDS.\|.SEIS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	485	RVLG.\|.GTEA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)