O43432: Eukaryotic translation initiation factor 4 gamma 3

General Information

Protein names	- Eukaryotic translation initiation factor 4 gamma 3 - eIF-4-gamma 3 - eIF-4G 3 - eIF4G 3 - eIF-4-gamma II - eIF4GII
Gene names	EIF4G3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43432

7 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MNSQPQTRSP FFQRPQIQPP RATIPNSSPS IRPGAQTPTA VYQANQHIMM VNHLPMPYPV
        70         80         90        100        110        120
PQGPQYCIPQ YRHSGPPYVG PPQQYPVQPP GPGPFYPGPG PGDFPNAYGT PFYPSQPVYQ
       130        140        150        160        170        180
SAPIIVPTQQ QPPPAKREKK TIRIRDPNQG GKDITEEIMS GGGSRNPTPP IGRPTSTPTP
       190        200        210        220        230        240
PQQLPSQVPE HSPVVYGTVE SAHLAASTPV TAASDQKQEE KPKPDPVLKS PSPVLRLVLS
       250        260        270        280        290        300
GEKKEQEGQT SETTAIVSIA ELPLPPSPTT VSSVARSTIA APTSSALSSQ PIFTTAIDDR
       310        320        330        340        350        360
CELSSPREDT IPIPSLTSCT ETSDPLPTNE NDDDICKKPC SVAPNDIPLV SSTNLINEIN
       370        380        390        400        410        420
GVSEKLSATE SIVEIVKQEV LPLTLELEIL ENPPEEMKLE CIPAPITPST VPSFPPTPPT
       430        440        450        460        470        480
PPASPPHTPV IVPAAATTVS SPSAAITVQR VLEEDESIRT CLSEDAKEIQ NKIEVEADGQ
       490        500        510        520        530        540
TEEILDSQNL NSRRSPVPAQ IAITVPKTWK KPKDRTRTTE EMLEAELELK AEEELSIDKV
       550        560        570        580        590        600
LESEQDKMSQ GFHPERDPSD LKKVKAVEEN GEEAEPVRNG AESVSEGEGI DANSGSTDSS
       610        620        630        640        650        660
GDGVTFPFKP ESWKPTDTEG KKQYDREFLL DFQFMPACIQ KPEGLPPISD VVLDKINQPK
       670        680        690        700        710        720
LPMRTLDPRI LPRGPDFTPA FADFGRQTPG GRGVPLLNVG SRRSQPGQRR EPRKIITVSV
       730        740        750        760        770        780
KEDVHLKKAE NAWKPSQKRD SQADDPENIK TQELFRKVRS ILNKLTPQMF NQLMKQVSGL
       790        800        810        820        830        840
TVDTEERLKG VIDLVFEKAI DEPSFSVAYA NMCRCLVTLK VPMADKPGNT VNFRKLLLNR
       850        860        870        880        890        900
CQKEFEKDKA DDDVFEKKQK ELEAASAPEE RTRLHDELEE AKDKARRRSI GNIKFIGELF
       910        920        930        940        950        960
KLKMLTEAIM HDCVVKLLKN HDEESLECLC RLLTTIGKDL DFEKAKPRMD QYFNQMEKIV
       970        980        990       1000       1010       1020
KERKTSSRIR FMLQDVIDLR LCNWVSRRAD QGPKTIEQIH KEAKIEEQEE QRKVQQLMTK
      1030       1040       1050       1060       1070       1080
EKRRPGVQRV DEGGWNTVQG AKNSRVLDPS KFLKITKPTI DEKIQLVPKA QLGSWGKGSS
      1090       1100       1110       1120       1130       1140
GGAKASETDA LRSSASSLNR FSALQPPAPS GSTPSTPVEF DSRRTLTSRG SMGREKNDKP
      1150       1160       1170       1180       1190       1200
LPSATARPNT FMRGGSSKDL LDNQSQEEQR REMLETVKQL TGGVDVERNS TEAERNKTRE
      1210       1220       1230       1240       1250       1260
SAKPEISAMS AHDKAALSEE ELERKSKSII DEFLHINDFK EAMQCVEELN AQGLLHVFVR
      1270       1280       1290       1300       1310       1320
VGVESTLERS QITRDHMGQL LYQLVQSEKL SKQDFFKGFS ETLELADDMA IDIPHIWLYL
      1330       1340       1350       1360       1370       1380
AELVTPMLKE GGISMRELTI EFSKPLLPVG RAGVLLSEIL HLLCKQMSHK KVGALWREAD
      1390       1400       1410       1420       1430       1440
LSWKDFLPEG EDVHNFLLEQ KLDFIESDSP CSSEALSKKE LSAEELYKRL EKLIIEDKAN
      1450       1460       1470       1480       1490       1500
DEQIFDWVEA NLDEIQMSSP TFLRALMTAV CKAAIIADSS TFRVDTAVIK QRVPILLKYL
      1510       1520       1530       1540       1550       1560
DSDTEKELQA LYALQASIVK LDQPANLLRM FFDCLYDEEV ISEDAFYKWE SSKDPAEQNG
      1570       1580
KGVALKSVTA FFTWLREAEE ESEDN

Isoforms

- Isoform 2 of Eukaryotic translation initiation factor 4 gamma 3 - Isoform 3 of Eukaryotic translation initiation factor 4 gamma 3 - Isoform 4 of Eukaryotic translation initiation factor 4 gamma 3

Sequence View

        10         20         30         40         50         60
MNSQPQTRSP FFQRPQIQPP RATIPNSSPS IRPGAQTPTA VYQANQHIMM VNHLPMPYPV
        70         80         90        100        110        120
PQGPQYCIPQ YRHSGPPYVG PPQQYPVQPP GPGPFYPGPG PGDFPNAYGT PFYPSQPVYQ
       130        140        150        160        170        180
SAPIIVPTQQ QPPPAKREKK TIRIRDPNQG GKDITEEIMS GGGSRNPTPP IGRPTSTPTP
       190        200        210        220        230        240
PQQLPSQVPE HSPVVYGTVE SAHLAASTPV TAASDQKQEE KPKPDPVLKS PSPVLRLVLS
       250        260        270        280        290        300
GEKKEQEGQT SETTAIVSIA ELPLPPSPTT VSSVARSTIA APTSSALSSQ PIFTTAIDDR
       310        320        330        340        350        360
CELSSPREDT IPIPSLTSCT ETSDPLPTNE NDDDICKKPC SVAPNDIPLV SSTNLINEIN
       370        380        390        400        410        420
GVSEKLSATE SIVEIVKQEV LPLTLELEIL ENPPEEMKLE CIPAPITPST VPSFPPTPPT
       430        440        450        460        470        480
PPASPPHTPV IVPAAATTVS SPSAAITVQR VLEEDESIRT CLSEDAKEIQ NKIEVEADGQ
       490        500        510        520        530        540
TEEILDSQNL NSRRSPVPAQ IAITVPKTWK KPKDRTRTTE EMLEAELELK AEEELSIDKV
       550        560        570        580        590        600
LESEQDKMSQ GFHPERDPSD LKKVKAVEEN GEEAEPVRNG AESVSEGEGI DANSGSTDSS
       610        620        630        640        650        660
GDGVTFPFKP ESWKPTDTEG KKQYDREFLL DFQFMPACIQ KPEGLPPISD VVLDKINQPK
       670        680        690        700        710        720
LPMRTLDPRI LPRGPDFTPA FADFGRQTPG GRGVPLLNVG SRRSQPGQRR EPRKIITVSV
       730        740        750        760        770        780
KEDVHLKKAE NAWKPSQKRD SQADDPENIK TQELFRKVRS ILNKLTPQMF NQLMKQVSGL
       790        800        810        820        830        840
TVDTEERLKG VIDLVFEKAI DEPSFSVAYA NMCRCLVTLK VPMADKPGNT VNFRKLLLNR
       850        860        870        880        890        900
CQKEFEKDKA DDDVFEKKQK ELEAASAPEE RTRLHDELEE AKDKARRRSI GNIKFIGELF
       910        920        930        940        950        960
KLKMLTEAIM HDCVVKLLKN HDEESLECLC RLLTTIGKDL DFEKAKPRMD QYFNQMEKIV
       970        980        990       1000       1010       1020
KERKTSSRIR FMLQDVIDLR LCNWVSRRAD QGPKTIEQIH KEAKIEEQEE QRKVQQLMTK
      1030       1040       1050       1060       1070       1080
EKRRPGVQRV DEGGWNTVQG AKNSRVLDPS KFLKITKPTI DEKIQLVPKA QLGSWGKGSS
      1090       1100       1110       1120       1130       1140
GGAKASETDA LRSSASSLNR FSALQPPAPS GSTPSTPVEF DSRRTLTSRG SMGREKNDKP
      1150       1160       1170       1180       1190       1200
LPSATARPNT FMRGGSSKDL LDNQSQEEQR REMLETVKQL TGGVDVERNS TEAERNKTRE
      1210       1220       1230       1240       1250       1260
SAKPEISAMS AHDKAALSEE ELERKSKSII DEFLHINDFK EAMQCVEELN AQGLLHVFVR
      1270       1280       1290       1300       1310       1320
VGVESTLERS QITRDHMGQL LYQLVQSEKL SKQDFFKGFS ETLELADDMA IDIPHIWLYL
      1330       1340       1350       1360       1370       1380
AELVTPMLKE GGISMRELTI EFSKPLLPVG RAGVLLSEIL HLLCKQMSHK KVGALWREAD
      1390       1400       1410       1420       1430       1440
LSWKDFLPEG EDVHNFLLEQ KLDFIESDSP CSSEALSKKE LSAEELYKRL EKLIIEDKAN
      1450       1460       1470       1480       1490       1500
DEQIFDWVEA NLDEIQMSSP TFLRALMTAV CKAAIIADSS TFRVDTAVIK QRVPILLKYL
      1510       1520       1530       1540       1550       1560
DSDTEKELQA LYALQASIVK LDQPANLLRM FFDCLYDEEV ISEDAFYKWE SSKDPAEQNG
      1570       1580
KGVALKSVTA FFTWLREAEE ESEDN         10         20         30         40         50         60
MNSQPQTRSP FFQRPQIQPP RATIPNSSPS IRPGAQTPTA VYQANQHIMM VNHLPMPYPV
        70         80         90        100        110        120
PQGPQYCIPQ YRHSGPPYVG PPQQYPVQPP GPGPFYPGPG PGDFPNAYGT PFYPSQPVYQ
       130        140        150        160        170        180
SAPIIVPTQQ QPPPAKREKK TIRIRDPNQG GKDITEEIMS GGGSRNPTPP IGRPTSTPTP
       190        200        210        220        230        240
PQQLPSQVPE HSPVVYGTVE SAHLAASTPV TAASDQKQEE KPKPDPVLKS PSPVLRLVLS
       250        260        270        280        290        300
GEKKEQEGQT SETTAIVSIA ELPLPPSPTT VSSVARSTIA APTSSALSSQ PIFTTAIDDR
       310        320        330        340        350        360
CELSSPREDT IPIPSLTSCT ETSDPLPTNE NDDDICKKPC SVAPNDIPLV SSTNLINEIN
       370        380        390        400        410        420
GVSEKLSATE SIVEIVKQEV LPLTLELEIL ENPPEEMKLE CIPAPITPST VPSFPPTPPT
       430        440        450        460        470        480
PPASPPHTPV IVPAAATTVS SPSAAITVQR VLEEDESIRT CLSEDAKEIQ NKIEVEADGQ
       490        500        510        520        530        540
TEEILDSQNL NSRRSPVPAQ IAITVPKTWK KPKDRTRTTE EMLEAELELK AEEELSIDKV
       550        560        570        580        590        600
LESEQDKMSQ GFHPERDPSD LKKVKAVEEN GEEAEPVRNG AESVSEGEGI DANSGSTDSS
       610        620        630        640        650        660
GDGVTFPFKP ESWKPTDTEG KKQYDREFLL DFQFMPACIQ KPEGLPPISD VVLDKINQPK
       670        680        690        700        710        720
LPMRTLDPRI LPRGPDFTPA FADFGRQTPG GRGVPLLNVG SRRSQPGQRR EPRKIITVSV
       730        740        750        760        770        780
KEDVHLKKAE NAWKPSQKRD SQADDPENIK TQELFRKVRS ILNKLTPQMF NQLMKQVSGL
       790        800        810        820        830        840
TVDTEERLKG VIDLVFEKAI DEPSFSVAYA NMCRCLVTLK VPMADKPGNT VNFRKLLLNR
       850        860        870        880        890        900
CQKEFEKDKA DDDVFEKKQK ELEAASAPEE RTRLHDELEE AKDKARRRSI GNIKFIGELF
       910        920        930        940        950        960
KLKMLTEAIM HDCVVKLLKN HDEESLECLC RLLTTIGKDL DFEKAKPRMD QYFNQMEKIV
       970        980        990       1000       1010       1020
KERKTSSRIR FMLQDVIDLR LCNWVSRRAD QGPKTIEQIH KEAKIEEQEE QRKVQQLMTK
      1030       1040       1050       1060       1070       1080
EKRRPGVQRV DEGGWNTVQG AKNSRVLDPS KFLKITKPTI DEKIQLVPKA QLGSWGKGSS
      1090       1100       1110       1120       1130       1140
GGAKASETDA LRSSASSLNR FSALQPPAPS GSTPSTPVEF DSRRTLTSRG SMGREKNDKP
      1150       1160       1170       1180       1190       1200
LPSATARPNT FMRGGSSKDL LDNQSQEEQR REMLETVKQL TGGVDVERNS TEAERNKTRE
      1210       1220       1230       1240       1250       1260
SAKPEISAMS AHDKAALSEE ELERKSKSII DEFLHINDFK EAMQCVEELN AQGLLHVFVR
      1270       1280       1290       1300       1310       1320
VGVESTLERS QITRDHMGQL LYQLVQSEKL SKQDFFKGFS ETLELADDMA IDIPHIWLYL
      1330       1340       1350       1360       1370       1380
AELVTPMLKE GGISMRELTI EFSKPLLPVG RAGVLLSEIL HLLCKQMSHK KVGALWREAD
      1390       1400       1410       1420       1430       1440
LSWKDFLPEG EDVHNFLLEQ KLDFIESDSP CSSEALSKKE LSAEELYKRL EKLIIEDKAN
      1450       1460       1470       1480       1490       1500
DEQIFDWVEA NLDEIQMSSP TFLRALMTAV CKAAIIADSS TFRVDTAVIK QRVPILLKYL
      1510       1520       1530       1540       1550       1560
DSDTEKELQA LYALQASIVK LDQPANLLRM FFDCLYDEEV ISEDAFYKWE SSKDPAEQNG
      1570       1580
KGVALKSVTA FFTWLREAEE ESEDN         10         20         30         40         50         60
MNSQPQTRSP FFQRPQIQPP RATIPNSSPS IRPGAQTPTA VYQANQHIMM VNHLPMPYPV
        70         80         90        100        110        120
PQGPQYCIPQ YRHSGPPYVG PPQQYPVQPP GPGPFYPGPG PGDFPNAYGT PFYPSQPVYQ
       130        140        150        160        170        180
SAPIIVPTQQ QPPPAKREKK TIRIRDPNQG GKDITEEIMS GGGSRNPTPP IGRPTSTPTP
       190        200        210        220        230        240
PQQLPSQVPE HSPVVYGTVE SAHLAASTPV TAASDQKQEE KPKPDPVLKS PSPVLRLVLS
       250        260        270        280        290        300
GEKKEQEGQT SETTAIVSIA ELPLPPSPTT VSSVARSTIA APTSSALSSQ PIFTTAIDDR
       310        320        330        340        350        360
CELSSPREDT IPIPSLTSCT ETSDPLPTNE NDDDICKKPC SVAPNDIPLV SSTNLINEIN
       370        380        390        400        410        420
GVSEKLSATE SIVEIVKQEV LPLTLELEIL ENPPEEMKLE CIPAPITPST VPSFPPTPPT
       430        440        450        460        470        480
PPASPPHTPV IVPAAATTVS SPSAAITVQR VLEEDESIRT CLSEDAKEIQ NKIEVEADGQ
       490        500        510        520        530        540
TEEILDSQNL NSRRSPVPAQ IAITVPKTWK KPKDRTRTTE EMLEAELELK AEEELSIDKV
       550        560        570        580        590        600
LESEQDKMSQ GFHPERDPSD LKKVKAVEEN GEEAEPVRNG AESVSEGEGI DANSGSTDSS
       610        620        630        640        650        660
GDGVTFPFKP ESWKPTDTEG KKQYDREFLL DFQFMPACIQ KPEGLPPISD VVLDKINQPK
       670        680        690        700        710        720
LPMRTLDPRI LPRGPDFTPA FADFGRQTPG GRGVPLLNVG SRRSQPGQRR EPRKIITVSV
       730        740        750        760        770        780
KEDVHLKKAE NAWKPSQKRD SQADDPENIK TQELFRKVRS ILNKLTPQMF NQLMKQVSGL
       790        800        810        820        830        840
TVDTEERLKG VIDLVFEKAI DEPSFSVAYA NMCRCLVTLK VPMADKPGNT VNFRKLLLNR
       850        860        870        880        890        900
CQKEFEKDKA DDDVFEKKQK ELEAASAPEE RTRLHDELEE AKDKARRRSI GNIKFIGELF
       910        920        930        940        950        960
KLKMLTEAIM HDCVVKLLKN HDEESLECLC RLLTTIGKDL DFEKAKPRMD QYFNQMEKIV
       970        980        990       1000       1010       1020
KERKTSSRIR FMLQDVIDLR LCNWVSRRAD QGPKTIEQIH KEAKIEEQEE QRKVQQLMTK
      1030       1040       1050       1060       1070       1080
EKRRPGVQRV DEGGWNTVQG AKNSRVLDPS KFLKITKPTI DEKIQLVPKA QLGSWGKGSS
      1090       1100       1110       1120       1130       1140
GGAKASETDA LRSSASSLNR FSALQPPAPS GSTPSTPVEF DSRRTLTSRG SMGREKNDKP
      1150       1160       1170       1180       1190       1200
LPSATARPNT FMRGGSSKDL LDNQSQEEQR REMLETVKQL TGGVDVERNS TEAERNKTRE
      1210       1220       1230       1240       1250       1260
SAKPEISAMS AHDKAALSEE ELERKSKSII DEFLHINDFK EAMQCVEELN AQGLLHVFVR
      1270       1280       1290       1300       1310       1320
VGVESTLERS QITRDHMGQL LYQLVQSEKL SKQDFFKGFS ETLELADDMA IDIPHIWLYL
      1330       1340       1350       1360       1370       1380
AELVTPMLKE GGISMRELTI EFSKPLLPVG RAGVLLSEIL HLLCKQMSHK KVGALWREAD
      1390       1400       1410       1420       1430       1440
LSWKDFLPEG EDVHNFLLEQ KLDFIESDSP CSSEALSKKE LSAEELYKRL EKLIIEDKAN
      1450       1460       1470       1480       1490       1500
DEQIFDWVEA NLDEIQMSSP TFLRALMTAV CKAAIIADSS TFRVDTAVIK QRVPILLKYL
      1510       1520       1530       1540       1550       1560
DSDTEKELQA LYALQASIVK LDQPANLLRM FFDCLYDEEV ISEDAFYKWE SSKDPAEQNG
      1570       1580
KGVALKSVTA FFTWLREAEE ESEDN

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O43432-1-unknown	MNSQPQ...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43432-1-unknown	MNSQPQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77562
O43432-121-unknown	SAPIIV...	121	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173779
O43432-121-unknown	SAPIIV...	121	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173780
O43432-121-unknown	SAPIIV...	121	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173781
O43432-121-	SAPIIV...	121		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43432-397-unknown	MKLECI...	397	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000444693
O43432-397-unknown	MKLECI...	397	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199324
O43432-397-unknown	MKLECI...	397	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199325
O43432-479-unknown	GQTEEI...	479	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10759
O43432-479-unknown	GQTEEI...	479	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153245
O43432-479-	GQTEEI...	479		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43432-479-	GQTEEI...	479		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O43432-479-	GQTEEI...	479		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O43432-548-unknown	MSQGFH...	548	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000442010
O43432-548-unknown	MSQGFH...	548	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199841
O43432-548-unknown	MSQGFH...	548	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199842

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PTPPQQ	182	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396083
...PTPPQQ	182	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155418
...PTPPQQ	182	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155419
...PTPPQQ	182	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155420
...ASDQKQ	217	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000395381
...ASDQKQ	217	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155781
...ASDQKQ	217	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155782
...ASDQKQ	217	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155783
...EVEADG	478	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10759
...EVEADG	478	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136670
...EVEADG	478	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136726
...ESEDN	1585	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ESEDN	1585	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73180
...ESEDN	1585	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73179

TopFIND

O43432: Eukaryotic translation initiation factor 4 gamma 3

General Information

7

N-termini

4

C-termini

1

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates