O43488: Aflatoxin B1 aldehyde reductase member 2

General Information

Protein names	- Aflatoxin B1 aldehyde reductase member 2 - 1.1.1.n11 - AFB1 aldehyde reductase 1 - AFB1-AR 1 - Aldoketoreductase 7 - Succinic semialdehyde reductase - SSA reductase
Gene names	AKR7A2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43488

6 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLSAASRVVS RAAVHCALRS PPPEARALAM SRPPPPRVAS VLGTMEMGRR MDAPASAAAV
        70         80         90        100        110        120
RAFLERGHTE LDTAFMYSDG QSETILGGLG LGLGGGDCRV KIATKANPWD GKSLKPDSVR
       130        140        150        160        170        180
SQLETSLKRL QCPQVDLFYL HAPDHGTPVE ETLHACQRLH QEGKFVELGL SNYASWEVAE
       190        200        210        220        230        240
ICTLCKSNGW ILPTVYQGMY NATTRQVETE LFPCLRHFGL RFYAYNPLAG GLLTGKYKYE
       250        260        270        280        290        300
DKDGKQPVGR FFGNSWAETY RNRFWKEHHF EAIALVEKAL QAAYGASAPS VTSAALRWMY
       310        320        330        340        350
HHSQLQGAHG DAVILGMSSL EQLEQNLAAT EEGPLEPAVV DAFNQAWHLV AHECPNYFR

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O43488-1-unknown	MLSAAS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43488-11-unknown	RAAVHC...	11		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000339084
O43488-29-	AMSRPP...	29			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O43488-29-	AMSRPP...	29			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O43488-29-	AMSRPP...	29			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O43488-29-	AMSRPP...	29			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O43488-29-	AMSRPP...	29			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
O43488-29-	AMSRPP...	29			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O43488-29-	AMSRPP...	29			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43488-29-unknown	AMSRPP...	29			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O43488-29-unknown	AMSRPP...	29			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O43488-51-acetylation	MDAPAS...	51	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O43488-222-unknown	FYAYNP...	222		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31717

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...HFGLRF	221	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31717
	...PNYFR	359	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
THRB_HUMAN	221	GLRF.\|.FYAY	inferred from experiment	unknown	MEROPS	Hayes JD	Ireland LS et al.:Molecular cloning, expression a... (S01.217)	9576847,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)