O43683: Mitotic checkpoint serine/threonine-protein kinase BUB1

General Information

Protein names	- Mitotic checkpoint serine/threonine-protein kinase BUB1 - hBUB1 - 2.7.11.1 - BUB1A
Gene names	BUB1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43683

4 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Mitotic checkpoint serine/threonine-protein kinase BUB1 - Isoform 3 of Mitotic checkpoint serine/threonine-protein kinase BUB1

Sequence View

        10         20         30         40         50         60
MDTPENVLQM LEAHMQSYKG NDPLGEWERY IQWVEENFPE NKEYLITLLE HLMKEFLDKK
        70         80         90        100        110        120
KYHNDPRFIS YCLKFAEYNS DLHQFFEFLY NHGIGTLSSP LYIAWAGHLE AQGELQHASA
       130        140        150        160        170        180
VLQRGIQNQA EPREFLQQQY RLFQTRLTET HLPAQARTSE PLHNVQVLNQ MITSKSNPGN
       190        200        210        220        230        240
NMACISKNQG SELSGVISSA CDKESNMERR VITISKSEYS VHSSLASKVD VEQVVMYCKE
       250        260        270        280        290        300
KLIRGESEFS FEELRAQKYN QRRKHEQWVN EDRHYMKRKE ANAFEEQLLK QKMDELHKKL
       310        320        330        340        350        360
HQVVETSHED LPASQERSEV NPARMGPSVG SQQELRAPCL PVTYQQTPVN MEKNPREAPP
       370        380        390        400        410        420
VVPPLANAIS AALVSPATSQ SIAPPVPLKA QTVTDSMFAV ASKDAGCVNK STHEFKPQSG
       430        440        450        460        470        480
AEIKEGCETH KVANTSSFHT TPNTSLGMVQ ATPSKVQPSP TVHTKEALGF IMNMFQAPTL
       490        500        510        520        530        540
PDISDDKDEW QSLDQNEDAF EAQFQKNVRS SGAWGVNKII SSLSSAFHVF EDGNKENYGL
       550        560        570        580        590        600
PQPKNKPTGA RTFGERSVSR LPSKPKEEVP HAEEFLDDST VWGIRCNKTL APSPKSPGDF
       610        620        630        640        650        660
TSAAQLASTP FHKLPVESVH ILEDKENVVA KQCTQATLDS CEENMVVPSR DGKFSPIQEK
       670        680        690        700        710        720
SPKQALSSHM YSASLLRLSQ PAAGGVLTCE AELGVEACRL TDTDAAIAED PPDAIAGLQA
       730        740        750        760        770        780
EWMQMSSLGT VDAPNFIVGN PWDDKLIFKL LSGLSKPVSS YPNTFEWQCK LPAIKPKTEF
       790        800        810        820        830        840
QLGSKLVYVH HLLGEGAFAQ VYEATQGDLN DAKNKQKFVL KVQKPANPWE FYIGTQLMER
       850        860        870        880        890        900
LKPSMQHMFM KFYSAHLFQN GSVLVGELYS YGTLLNAINL YKNTPEKVMP QGLVISFAMR
       910        920        930        940        950        960
MLYMIEQVHD CEIIHGDIKP DNFILGNGFL EQDDEDDLSA GLALIDLGQS IDMKLFPKGT
       970        980        990       1000       1010       1020
IFTAKCETSG FQCVEMLSNK PWNYQIDYFG VAATVYCMLF GTYMKVKNEG GECKPEGLFR
      1030       1040       1050       1060       1070       1080
RLPHLDMWNE FFHVMLNIPD CHHLPSLDLL RQKLKKVFQQ HYTNKIRALR NRLIVLLLEC

KRSRK         10         20         30         40         50         60
MDTPENVLQM LEAHMQSYKG NDPLGEWERY IQWVEENFPE NKEYLITLLE HLMKEFLDKK
        70         80         90        100        110        120
KYHNDPRFIS YCLKFAEYNS DLHQFFEFLY NHGIGTLSSP LYIAWAGHLE AQGELQHASA
       130        140        150        160        170        180
VLQRGIQNQA EPREFLQQQY RLFQTRLTET HLPAQARTSE PLHNVQVLNQ MITSKSNPGN
       190        200        210        220        230        240
NMACISKNQG SELSGVISSA CDKESNMERR VITISKSEYS VHSSLASKVD VEQVVMYCKE
       250        260        270        280        290        300
KLIRGESEFS FEELRAQKYN QRRKHEQWVN EDRHYMKRKE ANAFEEQLLK QKMDELHKKL
       310        320        330        340        350        360
HQVVETSHED LPASQERSEV NPARMGPSVG SQQELRAPCL PVTYQQTPVN MEKNPREAPP
       370        380        390        400        410        420
VVPPLANAIS AALVSPATSQ SIAPPVPLKA QTVTDSMFAV ASKDAGCVNK STHEFKPQSG
       430        440        450        460        470        480
AEIKEGCETH KVANTSSFHT TPNTSLGMVQ ATPSKVQPSP TVHTKEALGF IMNMFQAPTL
       490        500        510        520        530        540
PDISDDKDEW QSLDQNEDAF EAQFQKNVRS SGAWGVNKII SSLSSAFHVF EDGNKENYGL
       550        560        570        580        590        600
PQPKNKPTGA RTFGERSVSR LPSKPKEEVP HAEEFLDDST VWGIRCNKTL APSPKSPGDF
       610        620        630        640        650        660
TSAAQLASTP FHKLPVESVH ILEDKENVVA KQCTQATLDS CEENMVVPSR DGKFSPIQEK
       670        680        690        700        710        720
SPKQALSSHM YSASLLRLSQ PAAGGVLTCE AELGVEACRL TDTDAAIAED PPDAIAGLQA
       730        740        750        760        770        780
EWMQMSSLGT VDAPNFIVGN PWDDKLIFKL LSGLSKPVSS YPNTFEWQCK LPAIKPKTEF
       790        800        810        820        830        840
QLGSKLVYVH HLLGEGAFAQ VYEATQGDLN DAKNKQKFVL KVQKPANPWE FYIGTQLMER
       850        860        870        880        890        900
LKPSMQHMFM KFYSAHLFQN GSVLVGELYS YGTLLNAINL YKNTPEKVMP QGLVISFAMR
       910        920        930        940        950        960
MLYMIEQVHD CEIIHGDIKP DNFILGNGFL EQDDEDDLSA GLALIDLGQS IDMKLFPKGT
       970        980        990       1000       1010       1020
IFTAKCETSG FQCVEMLSNK PWNYQIDYFG VAATVYCMLF GTYMKVKNEG GECKPEGLFR
      1030       1040       1050       1060       1070       1080
RLPHLDMWNE FFHVMLNIPD CHHLPSLDLL RQKLKKVFQQ HYTNKIRALR NRLIVLLLEC

KRSRK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O43683-1-unknown	MDTPEN...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43683-1-unknown	MDTPEN...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68762
O43683-10-unknown	MLEAHM...	10	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000402883
O43683-10-unknown	MLEAHM...	10	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000409713
O43683-10-unknown	MLEAHM...	10	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000392219
O43683-10-unknown	MLEAHM...	10	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131711
O43683-396-unknown	SMFAVA...	396	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168658
O43683-396-unknown	SMFAVA...	396	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168659
O43683-396-	SMFAVA...	396		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O43683-396-	SMFAVA...	396		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43683-396-	SMFAVA...	396		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O43683-396-	SMFAVA...	396		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KYHNDP	65	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000392219
...KYHNDP	65	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112372
...KYHNDP	65	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112371
...QYRLFQ	143	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000409713
...QYRLFQ	143	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112369
...QYRLFQ	143	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112368
...HLPAQA	155	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000402883
...HLPAQA	155	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112366
...HLPAQA	155	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112365
...KRSRK	1085	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KRSRK	1085	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64380
...KRSRK	1085	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64381

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)