O43815: Striatin

General Information

Protein names	- Striatin
Gene names	STRN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43815

8 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDEQAGPGVF FSNNHPGAGG AKGLGPLAEA AAAGDGAAAA GAARAQYSLP GILHFLQHEW
        70         80         90        100        110        120
ARFEVERAQW EVERAELQAQ IAFLQGERKG QENLKKDLVR RIKMLEYALK QERAKYHKLK
       130        140        150        160        170        180
YGTELNQGDM KPPSYDSDEG NETEVQPQQN SQLMWKQGRQ LLRQYLQEVG YTDTILDVKS
       190        200        210        220        230        240
KRVRALLGFS SDVTDREDDK NQDSVVNGTE AEVKETAMIA KSELTDSASV LDNFKFLESA
       250        260        270        280        290        300
AADFSDEDED DDVDGREKSV IDTSTIVRKK ALPDSGEDRD TKEALKEFDF LVTSEEGDNE
       310        320        330        340        350        360
SRSAGDGTDW EKEDQCLMPE AWNVDQGVIT KLKEQYKKER KGKKGVKRPN RSKLQDMLAN
       370        380        390        400        410        420
LRDVDELPSL QPSVGSPSRP SSSRLPEHEI NRADEVEALT FPPSSGKSFI MGADEALESE
       430        440        450        460        470        480
LGLGELAGLT VANEADSLTY DIANNKDALR KTWNPKFTLR SHFDGIRALA FHPIEPVLIT
       490        500        510        520        530        540
ASEDHTLKMW NLQKTAPAKK STSLDVEPIY TFRAHKGPVL CVVMSSNGEQ CYSGGTDGLI
       550        560        570        580        590        600
QGWNTTNPNI DPYDSYDPSV LRGPLLGHTD AVWGLAYSAA HQRLLSCSAD GTLRLWNTTE
       610        620        630        640        650        660
VAPALSVFND TKELGIPASV DLVSSDPSHM VASFSKGYTS IFNMETQQRI LTLESNVDTT
       670        680        690        700        710        720
ANSSCQINRV ISHPTLPISI TAHEDRHIKF YDNNTGKLIH SMVAHLEAVT SLAVDPNGLY
       730        740        750        760        770        780
LMSGSHDCSI RLWNLESKTC IQEFTAHRKK FEESIHDVAF HPSKCYIASA GADALAKVFV

Isoforms

- Isoform 2 of Striatin

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O43815-1-unknown	MDEQAG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43815-1-unknown	MDEQAG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90980
O43815-36-	GAAAAG...	36		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O43815-36-	GAAAAG...	36		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O43815-244-unknown	FSDEDE...	244	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10769
O43815-244-unknown	FSDEDE...	244	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147789
O43815-290-unknown	FLVTSE...	290	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10771
O43815-290-unknown	FLVTSE...	290	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149284
O43815-398-	ALTFPP...	398		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O43815-398-unknown	ALTFPP...	398	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165172
O43815-437-unknown	SLTYDI...	437	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10773
O43815-437-unknown	SLTYDI...	437		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O43815-437-unknown	SLTYDI...	437	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151795
O43815-437-	SLTYDI...	437		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O43815-437-	SLTYDI...	437		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O43815-437-	SLTYDI...	437		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O43815-437-	SLTYDI...	437		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O43815-437-	SLTYDI...	437		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O43815-437-	SLTYDI...	437		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
O43815-437-	SLTYDI...	437		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SAAADF	243	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10769
...SAAADF	243	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131145
...LKEFDF	289	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10771
...LKEFDF	289	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132669
...ANEADS	436	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10773
...ANEADS	436	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135199
...AKVFV	780	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AKVFV	780	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86598

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	243	AADF.\|.FSDE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	289	EFDF.\|.FLVT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	436	EADS.\|.SLTY	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)