O60216: Double-strand-break repair protein rad21 homolog

General Information

Protein names	- Double-strand-break repair protein rad21 homolog - hHR21 {ECO:0000303\|PubMed:8812457} - Nuclear matrix protein 1 {ECO:0000303\|PubMed:10623634} - NXP-1 {ECO:0000303\|PubMed:10623634} - SCC1 homolog - 64-kDa C-terminal product {ECO:0000303\|PubMed:12417729} - 64-kDa carboxy-terminal product {ECO:0000303\|PubMed:12417729} - 65-kDa carboxy-terminal product {ECO:0000303\|PubMed:11875078}
Gene names	RAD21
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60216

10 N-termini

7 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MFYAHFVLSK RGPLAKIWLA AHWDKKLTKA HVFECNLESS VESIISPKVK MALRTSGHLL
        70         80         90        100        110        120
LGVVRIYHRK AKYLLADCNE AFIKIKMAFR PGVVDLPEEN REAAYNAITL PEEFHDFDQP
       130        140        150        160        170        180
LPDLDDIDVA QQFSLNQSRV EEITMREEVG NISILQENDF GDFGMDDREI MREGSAFEDD
       190        200        210        220        230        240
DMLVSTTTSN LLLESEQSTS NLNEKINHLE YEDQYKDDNF GEGNDGGILD DKLISNNDGG
       250        260        270        280        290        300
IFDDPPALSE AGVMLPEQPA HDDMDEDDNV SMGGPDSPDS VDPVEPMPTM TDQTTLVPNE
       310        320        330        340        350        360
EEAFALEPID ITVKETKAKR KRKLIVDSVK ELDSKTIRAQ LSDYSDIVTT LDLAPPTKKL
       370        380        390        400        410        420
MMWKETGGVE KLFSLPAQPL WNNRLLKLFT RCLTPLVPED LRKRRKGGEA DNLDEFLKEF
       430        440        450        460        470        480
ENPEVPREDQ QQQHQQRDVI DEPIIEEPSR LQESVMEASR TNIDESAMPP PPPQGVKRKA
       490        500        510        520        530        540
GQIDPEPVMP PQQVEQMEIP PVELPPEEPP NICQLIPELE LLPEKEKEKE KEKEDDEEEE
       550        560        570        580        590        600
DEDASGGDQD QEERRWNKRT QQMLHGLQRA LAKTGAESIS LLELCRNTNR KQAAAKFYSF
       610        620        630
LVLKKQQAIE LTQEEPYSDI IATPGPRFHI I

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 7 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O60216-1-unknown	MFYAHF...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60216-129-	VAQQFS...	129		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60216-129-	VAQQFS...	129		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O60216-129-	VAQQFS...	129		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O60216-129-unknown	VAQQFS...	129	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1438
O60216-280-	SVDPVE...	280		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60216-280-	SVDPVE...	280		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O60216-280-unknown	SVDPVE...	280	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1439
O60216-280-unknown	SVDPVE...	280	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2776
O60216-280-unknown	SVDPVE...	280	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60216-454-	SVMEAS...	454		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O60216-456-unknown	MEASRT...	456	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000428003
O60216-466-	SAMPPP...	466		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O60216-497-unknown	MEIPPV...	497	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000428513
O60216-563-unknown	MLHGLQ...	563	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000430273

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DFDQPL	120	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428158
...PLPDLD	124	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000430524
...LDDIDV	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1438
...GEGNDG	225	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000427923
...NDGGIL	228	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000429342
...PDSPDS	279	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1439
...PDSPDS	279	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2776
...PDSPDS	279	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RFHII	631	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	128	DIDV.\|.VAQQ	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> RAD21_HUMAN @128
CASP3_HUMAN	279	SPDS.\|.SVDP	inferred from experiment	unknown	MEROPS	Cryns VL	Chen F et al.:Caspase proteolysis of the cohe... (C14.003)	11875078,
CASP7_HUMAN	279	SPDS.\|.SVDP	inferred from experiment	unknown	MEROPS		Merops CASP7_HUMAN -> RAD21_HUMAN @279

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)