O60232: Protein ZNRD2 {ECO:0000305}

General Information

Protein names	- Protein ZNRD2 {ECO:0000305} - Autoantigen p27 {ECO:0000303\|PubMed:9486406} - Sjoegren syndrome/scleroderma autoantigen 1 - Zinc ribbon domain-containing protein 2 {ECO:0000305}
Gene names	SSSCA1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60232

13 N-termini

4 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MALNGAEVDD FSWEPPTEAE TKVLQARRER QDRISRLMGD YLLRGYRMLG ETCADCGTIL
        70         80         90        100        110        120
LQDKQRKIYC VACQELDSDV DKDNPALNAQ AALSQAREHQ LASASELPLG SRPAPQPPVP
       130        140        150        160        170        180
RPEHCEGAAA GLKAAQGPPA PAVPPNTDVM ACTQTALLQK LTWASAELGS STSLETSIQL
       190
CGLIRACAEA LRSLQQLQH

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

13 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O60232-2-unknown	MALNGA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60232-2-Acetylation	ALNGAE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60232-2-Acetylation	ALNGAE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O60232-5-	GAEVDD...	5			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60232-7-unknown	EVDDFS...	7		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000435432
O60232-12-	SWEPPT...	12			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O60232-12-	SWEPPT...	12			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60232-12-	SWEPPT...	12			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O60232-38-unknown	MGDYLL...	38		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000434381
O60232-38-unknown	MGDYLL...	38		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000432938
O60232-56-unknown	CGTILL...	56		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10807
O60232-56-unknown	CGTILL...	56		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1440
O60232-78-unknown	SDVDKD...	78		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10808
O60232-80-unknown	VDKDNP...	80		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10809
O60232-82-	KDNPAL...	82			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O60232-82-	KDNPAL...	82			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
O60232-82-unknown	KDNPAL...	82			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O60232-86-	ALNAQA...	86			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
O60232-86-	ALNAQA...	86			Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
O60232-86-unknown	ALNAQA...	86			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ETCADC	55	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10807
...ETCADC	55	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1440
...CQELDS	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10808
...ELDSDV	79	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10809
...QQLQH	199	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	55	CADC.\|.CGTI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CASP3_HUMAN	55	CADC.\|.CGTI	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> SSA27_HUMAN @55
GRAB_HUMAN	77	ELDS.\|.SDVD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	79	DSDV.\|.VDKD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)