O60256: Phosphoribosyl pyrophosphate synthase-associated protein 2

General Information

Protein names	- Phosphoribosyl pyrophosphate synthase-associated protein 2 - PRPP synthase-associated protein 2 - 41 kDa phosphoribosypyrophosphate synthetase-associated protein - PAP41
Gene names	PRPSAP2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60256

6 N-termini

9 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Phosphoribosyl pyrophosphate synthase-associated protein 2 - Isoform 3 of Phosphoribosyl pyrophosphate synthase-associated protein 2 - Isoform 4 of Phosphoribosyl pyrophosphate synthase-associated protein 2

Sequence View

        10         20         30         40         50         60
MFCVTPPELE TKMNITKGGL VLFSANSNSS CMELSKKIAE RLGVEMGKVQ VYQEPNRETR
        70         80         90        100        110        120
VQIQESVRGK DVFIIQTVSK DVNTTIMELL IMVYACKTSC AKSIIGVIPY FPYSKQCKMR
       130        140        150        160        170        180
KRGSIVSKLL ASMMCKAGLT HLITMDLHQK EIQGFFNIPV DNLRASPFLL QYIQEEIPDY
       190        200        210        220        230        240
RNAVIVAKSP ASAKRAQSFA ERLRLGIAVI HGEAQDAESD LVDGRHSPPM VRSVAAIHPS
       250        260        270        280        290        300
LEIPMLIPKE KPPITVVGDV GGRIAIIVDD IIDDVDSFLA AAETLKERGA YKIFVMATHG
       310        320        330        340        350        360
LLSSDAPRRI EESAIDEVVV TNTIPHEVQK LQCPKIKTVD ISMILSEAIR RIHNGESMSY

LFRNIGLDD         10         20         30         40         50         60
MFCVTPPELE TKMNITKGGL VLFSANSNSS CMELSKKIAE RLGVEMGKVQ VYQEPNRETR
        70         80         90        100        110        120
VQIQESVRGK DVFIIQTVSK DVNTTIMELL IMVYACKTSC AKSIIGVIPY FPYSKQCKMR
       130        140        150        160        170        180
KRGSIVSKLL ASMMCKAGLT HLITMDLHQK EIQGFFNIPV DNLRASPFLL QYIQEEIPDY
       190        200        210        220        230        240
RNAVIVAKSP ASAKRAQSFA ERLRLGIAVI HGEAQDAESD LVDGRHSPPM VRSVAAIHPS
       250        260        270        280        290        300
LEIPMLIPKE KPPITVVGDV GGRIAIIVDD IIDDVDSFLA AAETLKERGA YKIFVMATHG
       310        320        330        340        350        360
LLSSDAPRRI EESAIDEVVV TNTIPHEVQK LQCPKIKTVD ISMILSEAIR RIHNGESMSY

LFRNIGLDD         10         20         30         40         50         60
MFCVTPPELE TKMNITKGGL VLFSANSNSS CMELSKKIAE RLGVEMGKVQ VYQEPNRETR
        70         80         90        100        110        120
VQIQESVRGK DVFIIQTVSK DVNTTIMELL IMVYACKTSC AKSIIGVIPY FPYSKQCKMR
       130        140        150        160        170        180
KRGSIVSKLL ASMMCKAGLT HLITMDLHQK EIQGFFNIPV DNLRASPFLL QYIQEEIPDY
       190        200        210        220        230        240
RNAVIVAKSP ASAKRAQSFA ERLRLGIAVI HGEAQDAESD LVDGRHSPPM VRSVAAIHPS
       250        260        270        280        290        300
LEIPMLIPKE KPPITVVGDV GGRIAIIVDD IIDDVDSFLA AAETLKERGA YKIFVMATHG
       310        320        330        340        350        360
LLSSDAPRRI EESAIDEVVV TNTIPHEVQK LQCPKIKTVD ISMILSEAIR RIHNGESMSY

LFRNIGLDD

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 9 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O60256-1-Acetylation	MFCVTP...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60256-1-Acetylation	MFCVTP...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100565
O60256-1-Acetylation	MFCVTP...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100566
O60256-1-unknown	MFCVTP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79217
O60256-1-unknown	MFCVTP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79218
O60256-13-acetylation	MNITKG...	13	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O60256-13-acetylation	MNITKG...	13	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181091
O60256-13-acetylation	MNITKG...	13	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181092
O60256-87-unknown	MELLIM...	87		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79219
O60256-87-unknown	MELLIM...	87		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000443967
O60256-87-unknown	MELLIM...	87		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt102459
O60256-87-unknown	MELLIM...	87		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt102458
O60256-233-	SVAAIH...	233			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O60256-233-	SVAAIH...	233			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60256-233-	SVAAIH...	233			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
O60256-233-unknown	SVAAIH...	233		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165008
O60256-233-unknown	SVAAIH...	233		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165010
O60256-233-unknown	SVAAIH...	233		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165009

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GGLVLF	22	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000459441
...GGLVLF	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153685
...GGLVLF	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153686
...LLIMVY	93	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000460138
...LLIMVY	93	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154294
...CAKSII	104	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000458600
...CAKSII	104	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154428
...CAKSII	104	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154427
...KAGLTH	140	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000395127
...KAGLTH	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154866
...KAGLTH	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154868
...KAGLTH	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154867
...YIQEEI	176	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000460967
...YIQEEI	176	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000415446
...YIQEEI	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155347
...YIQEEI	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155349
...YIQEEI	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155348
...PASAKR	194	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000416964
...PASAKR	194	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155551
...PASAKR	194	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155553
...PASAKR	194	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155552
...SLEIPM	244	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000401144
...IAIIVD	268	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399625
...IAIIVD	268	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000402612
...IGLDD	369	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...IGLDD	369	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74837
...IGLDD	369	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74836
...IGLDD	369	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74835

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)