O60524: Nuclear export mediator factor NEMF

General Information

Protein names	- Nuclear export mediator factor NEMF - Antigen NY-CO-1 - Serologically defined colon cancer antigen 1
Gene names	NEMF
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60524

4 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Nuclear export mediator factor NEMF - Isoform 3 of Nuclear export mediator factor NEMF - Isoform 4 of Nuclear export mediator factor NEMF - Isoform 5 of Nuclear export mediator factor NEMF

Sequence View

        10         20         30         40         50         60
MKSRFSTIDL RAVLAELNAS LLGMRVNNVY DVDNKTYLIR LQKPDFKATL LLESGIRIHT
        70         80         90        100        110        120
TEFEWPKNMM PSSFAMKCRK HLKSRRLVSA KQLGVDRIVD FQFGSDEAAY HLIIELYDRG
       130        140        150        160        170        180
NIVLTDYEYV ILNILRFRTD EADDVKFAVR ERYPLDHARA AEPLLTLERL TEIVASAPKG
       190        200        210        220        230        240
ELLKRVLNPL LPYGPALIEH CLLENGFSGN VKVDEKLETK DIEKVLVSLQ KAEDYMKTTS
       250        260        270        280        290        300
NFSGKGYIIQ KREIKPSLEA DKPVEDILTY EEFHPFLFSQ HSQCPYIEFE SFDKAVDEFY
       310        320        330        340        350        360
SKIEGQKIDL KALQQEKQAL KKLDNVRKDH ENRLEALQQA QEIDKLKGEL IEMNLQIVDR
       370        380        390        400        410        420
AIQVVRSALA NQIDWTEIGL IVKEAQAQGD PVASAIKELK LQTNHVTMLL RNPYLLSEEE
       430        440        450        460        470        480
DDDVDGDVNV EKNETEPPKG KKKKQKNKQL QKPQKNKPLL VDVDLSLSAY ANAKKYYDHK
       490        500        510        520        530        540
RYAAKKTQKT VEAAEKAFKS AEKKTKQTLK EVQTVTSIQK ARKVYWFEKF LWFISSENYL
       550        560        570        580        590        600
IIGGRDQQQN EIIVKRYLTP GDIYVHADLH GATSCVIKNP TGEPIPPRTL TEAGTMALCY
       610        620        630        640        650        660
SAAWDARVIT SAWWVYHHQV SKTAPTGEYL TTGSFMIRGK KNFLPPSYLM MGFSFLFKVD
       670        680        690        700        710        720
ESCVWRHQGE RKVRVQDEDM ETLASCTSEL ISEEMEQLDG GDTSSDEDKE EHETPVEVEL
       730        740        750        760        770        780
MTQVDQEDIT LQSGRDELNE ELIQEESSED EGEYEEVRKD QDSVGEMKDE GEETLNYPDT
       790        800        810        820        830        840
TIDLSHLQPQ RSIQKLASKE ESSNSSDSKS QSRRHLSAKE RREMKKKKLP SDSGDLEALE
       850        860        870        880        890        900
GKDKEKESTV HIETHQNTSK NVAAVQPMKR GQKSKMKKMK EKYKDQDEED RELIMKLLGS
       910        920        930        940        950        960
AGSNKEEKGK KGKKGKTKDE PVKKQPQKPR GGQRVSDNIK KETPFLEVIT HELQDFAVDD
       970        980        990       1000       1010       1020
PHDDKEEQDL DQQGNEENLF DSLTGQPHPE DVLLFAIPIC APYTTMTNYK YKVKLTPGVQ
      1030       1040       1050       1060       1070
KKGKAAKTAL NSFMHSKEAT AREKDLFRSV KDTDLSRNIP GKVKVSAPNL LNVKRK         10         20         30         40         50         60
MKSRFSTIDL RAVLAELNAS LLGMRVNNVY DVDNKTYLIR LQKPDFKATL LLESGIRIHT
        70         80         90        100        110        120
TEFEWPKNMM PSSFAMKCRK HLKSRRLVSA KQLGVDRIVD FQFGSDEAAY HLIIELYDRG
       130        140        150        160        170        180
NIVLTDYEYV ILNILRFRTD EADDVKFAVR ERYPLDHARA AEPLLTLERL TEIVASAPKG
       190        200        210        220        230        240
ELLKRVLNPL LPYGPALIEH CLLENGFSGN VKVDEKLETK DIEKVLVSLQ KAEDYMKTTS
       250        260        270        280        290        300
NFSGKGYIIQ KREIKPSLEA DKPVEDILTY EEFHPFLFSQ HSQCPYIEFE SFDKAVDEFY
       310        320        330        340        350        360
SKIEGQKIDL KALQQEKQAL KKLDNVRKDH ENRLEALQQA QEIDKLKGEL IEMNLQIVDR
       370        380        390        400        410        420
AIQVVRSALA NQIDWTEIGL IVKEAQAQGD PVASAIKELK LQTNHVTMLL RNPYLLSEEE
       430        440        450        460        470        480
DDDVDGDVNV EKNETEPPKG KKKKQKNKQL QKPQKNKPLL VDVDLSLSAY ANAKKYYDHK
       490        500        510        520        530        540
RYAAKKTQKT VEAAEKAFKS AEKKTKQTLK EVQTVTSIQK ARKVYWFEKF LWFISSENYL
       550        560        570        580        590        600
IIGGRDQQQN EIIVKRYLTP GDIYVHADLH GATSCVIKNP TGEPIPPRTL TEAGTMALCY
       610        620        630        640        650        660
SAAWDARVIT SAWWVYHHQV SKTAPTGEYL TTGSFMIRGK KNFLPPSYLM MGFSFLFKVD
       670        680        690        700        710        720
ESCVWRHQGE RKVRVQDEDM ETLASCTSEL ISEEMEQLDG GDTSSDEDKE EHETPVEVEL
       730        740        750        760        770        780
MTQVDQEDIT LQSGRDELNE ELIQEESSED EGEYEEVRKD QDSVGEMKDE GEETLNYPDT
       790        800        810        820        830        840
TIDLSHLQPQ RSIQKLASKE ESSNSSDSKS QSRRHLSAKE RREMKKKKLP SDSGDLEALE
       850        860        870        880        890        900
GKDKEKESTV HIETHQNTSK NVAAVQPMKR GQKSKMKKMK EKYKDQDEED RELIMKLLGS
       910        920        930        940        950        960
AGSNKEEKGK KGKKGKTKDE PVKKQPQKPR GGQRVSDNIK KETPFLEVIT HELQDFAVDD
       970        980        990       1000       1010       1020
PHDDKEEQDL DQQGNEENLF DSLTGQPHPE DVLLFAIPIC APYTTMTNYK YKVKLTPGVQ
      1030       1040       1050       1060       1070
KKGKAAKTAL NSFMHSKEAT AREKDLFRSV KDTDLSRNIP GKVKVSAPNL LNVKRK         10         20         30         40         50         60
MKSRFSTIDL RAVLAELNAS LLGMRVNNVY DVDNKTYLIR LQKPDFKATL LLESGIRIHT
        70         80         90        100        110        120
TEFEWPKNMM PSSFAMKCRK HLKSRRLVSA KQLGVDRIVD FQFGSDEAAY HLIIELYDRG
       130        140        150        160        170        180
NIVLTDYEYV ILNILRFRTD EADDVKFAVR ERYPLDHARA AEPLLTLERL TEIVASAPKG
       190        200        210        220        230        240
ELLKRVLNPL LPYGPALIEH CLLENGFSGN VKVDEKLETK DIEKVLVSLQ KAEDYMKTTS
       250        260        270        280        290        300
NFSGKGYIIQ KREIKPSLEA DKPVEDILTY EEFHPFLFSQ HSQCPYIEFE SFDKAVDEFY
       310        320        330        340        350        360
SKIEGQKIDL KALQQEKQAL KKLDNVRKDH ENRLEALQQA QEIDKLKGEL IEMNLQIVDR
       370        380        390        400        410        420
AIQVVRSALA NQIDWTEIGL IVKEAQAQGD PVASAIKELK LQTNHVTMLL RNPYLLSEEE
       430        440        450        460        470        480
DDDVDGDVNV EKNETEPPKG KKKKQKNKQL QKPQKNKPLL VDVDLSLSAY ANAKKYYDHK
       490        500        510        520        530        540
RYAAKKTQKT VEAAEKAFKS AEKKTKQTLK EVQTVTSIQK ARKVYWFEKF LWFISSENYL
       550        560        570        580        590        600
IIGGRDQQQN EIIVKRYLTP GDIYVHADLH GATSCVIKNP TGEPIPPRTL TEAGTMALCY
       610        620        630        640        650        660
SAAWDARVIT SAWWVYHHQV SKTAPTGEYL TTGSFMIRGK KNFLPPSYLM MGFSFLFKVD
       670        680        690        700        710        720
ESCVWRHQGE RKVRVQDEDM ETLASCTSEL ISEEMEQLDG GDTSSDEDKE EHETPVEVEL
       730        740        750        760        770        780
MTQVDQEDIT LQSGRDELNE ELIQEESSED EGEYEEVRKD QDSVGEMKDE GEETLNYPDT
       790        800        810        820        830        840
TIDLSHLQPQ RSIQKLASKE ESSNSSDSKS QSRRHLSAKE RREMKKKKLP SDSGDLEALE
       850        860        870        880        890        900
GKDKEKESTV HIETHQNTSK NVAAVQPMKR GQKSKMKKMK EKYKDQDEED RELIMKLLGS
       910        920        930        940        950        960
AGSNKEEKGK KGKKGKTKDE PVKKQPQKPR GGQRVSDNIK KETPFLEVIT HELQDFAVDD
       970        980        990       1000       1010       1020
PHDDKEEQDL DQQGNEENLF DSLTGQPHPE DVLLFAIPIC APYTTMTNYK YKVKLTPGVQ
      1030       1040       1050       1060       1070
KKGKAAKTAL NSFMHSKEAT AREKDLFRSV KDTDLSRNIP GKVKVSAPNL LNVKRK         10         20         30         40         50         60
MKSRFSTIDL RAVLAELNAS LLGMRVNNVY DVDNKTYLIR LQKPDFKATL LLESGIRIHT
        70         80         90        100        110        120
TEFEWPKNMM PSSFAMKCRK HLKSRRLVSA KQLGVDRIVD FQFGSDEAAY HLIIELYDRG
       130        140        150        160        170        180
NIVLTDYEYV ILNILRFRTD EADDVKFAVR ERYPLDHARA AEPLLTLERL TEIVASAPKG
       190        200        210        220        230        240
ELLKRVLNPL LPYGPALIEH CLLENGFSGN VKVDEKLETK DIEKVLVSLQ KAEDYMKTTS
       250        260        270        280        290        300
NFSGKGYIIQ KREIKPSLEA DKPVEDILTY EEFHPFLFSQ HSQCPYIEFE SFDKAVDEFY
       310        320        330        340        350        360
SKIEGQKIDL KALQQEKQAL KKLDNVRKDH ENRLEALQQA QEIDKLKGEL IEMNLQIVDR
       370        380        390        400        410        420
AIQVVRSALA NQIDWTEIGL IVKEAQAQGD PVASAIKELK LQTNHVTMLL RNPYLLSEEE
       430        440        450        460        470        480
DDDVDGDVNV EKNETEPPKG KKKKQKNKQL QKPQKNKPLL VDVDLSLSAY ANAKKYYDHK
       490        500        510        520        530        540
RYAAKKTQKT VEAAEKAFKS AEKKTKQTLK EVQTVTSIQK ARKVYWFEKF LWFISSENYL
       550        560        570        580        590        600
IIGGRDQQQN EIIVKRYLTP GDIYVHADLH GATSCVIKNP TGEPIPPRTL TEAGTMALCY
       610        620        630        640        650        660
SAAWDARVIT SAWWVYHHQV SKTAPTGEYL TTGSFMIRGK KNFLPPSYLM MGFSFLFKVD
       670        680        690        700        710        720
ESCVWRHQGE RKVRVQDEDM ETLASCTSEL ISEEMEQLDG GDTSSDEDKE EHETPVEVEL
       730        740        750        760        770        780
MTQVDQEDIT LQSGRDELNE ELIQEESSED EGEYEEVRKD QDSVGEMKDE GEETLNYPDT
       790        800        810        820        830        840
TIDLSHLQPQ RSIQKLASKE ESSNSSDSKS QSRRHLSAKE RREMKKKKLP SDSGDLEALE
       850        860        870        880        890        900
GKDKEKESTV HIETHQNTSK NVAAVQPMKR GQKSKMKKMK EKYKDQDEED RELIMKLLGS
       910        920        930        940        950        960
AGSNKEEKGK KGKKGKTKDE PVKKQPQKPR GGQRVSDNIK KETPFLEVIT HELQDFAVDD
       970        980        990       1000       1010       1020
PHDDKEEQDL DQQGNEENLF DSLTGQPHPE DVLLFAIPIC APYTTMTNYK YKVKLTPGVQ
      1030       1040       1050       1060       1070
KKGKAAKTAL NSFMHSKEAT AREKDLFRSV KDTDLSRNIP GKVKVSAPNL LNVKRK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O60524-1-unknown	MKSRFS...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O60524-1-unknown	MKSRFS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82609
O60524-1-unknown	MKSRFS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82610
O60524-1-unknown	MKSRFS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82611
O60524-722-unknown	TQVDQE...	722	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10825
O60524-722-unknown	TQVDQE...	722	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt155651
O60524-722-unknown	TQVDQE...	722	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt155832
O60524-722-unknown	TQVDQE...	722	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt155868
O60524-770-unknown	EGEETL...	770	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10829
O60524-770-unknown	EGEETL...	770	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156118
O60524-770-unknown	EGEETL...	770	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156243
O60524-770-unknown	EGEETL...	770	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156266
O60524-797-unknown	ASKEES...	797	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13767
O60524-797-unknown	ASKEES...	797	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156289
O60524-797-unknown	ASKEES...	797	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156375
O60524-797-unknown	ASKEES...	797	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156415

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EVELMT	721	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10825
...EVELMT	721	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139093
...EVELMT	721	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139284
...EVELMT	721	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139321
...GEMKDE	769	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10829
...GEMKDE	769	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139581
...GEMKDE	769	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139711
...GEMKDE	769	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139735
...SIQKLA	796	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13767
...SIQKLA	796	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139761
...SIQKLA	796	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139854
...SIQKLA	796	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139895
...NVKRK	1076	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...NVKRK	1076	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78226
...NVKRK	1076	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78228
...NVKRK	1076	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78229
...NVKRK	1076	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78227

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	721	ELMT.\|.TQVD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	769	MKDE.\|.EGEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	796	QKLA.\|.ASKE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)