O60583: Cyclin-T2 {ECO:0000250|UniProtKB:Q7TQK0}

General Information

Protein names	- Cyclin-T2 {ECO:0000250\|UniProtKB:Q7TQK0} - CycT2 {ECO:0000250\|UniProtKB:Q7TQK0}
Gene names	CCNT2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60583

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASGRGASSR WFFTREQLEN TPSRRCGVEA DKELSCRQQA ANLIQEMGQR LNVSQLTINT
        70         80         90        100        110        120
AIVYMHRFYM HHSFTKFNKN IISSTALFLA AKVEEQARKL EHVIKVAHAC LHPLEPLLDT
       130        140        150        160        170        180
KCDAYLQQTQ ELVILETIML QTLGFEITIE HPHTDVVKCT QLVRASKDLA QTSYFMATNS
       190        200        210        220        230        240
LHLTTFCLQY KPTVIACVCI HLACKWSNWE IPVSTDGKHW WEYVDPTVTL ELLDELTHEF
       250        260        270        280        290        300
LQILEKTPNR LKKIRNWRAN QAARKPKVDG QVSETPLLGS SLVQNSILVD SVTGVPTNPS
       310        320        330        340        350        360
FQKPSTSAFP APVPLNSGNI SVQDSHTSDN LSMLATGMPS TSYGLSSHQE WPQHQDSART
       370        380        390        400        410        420
EQLYSQKQET SLSGSQYNIN FQQGPSISLH SGLHHRPDKI SDHSSVKQEY THKAGSSKHH
       430        440        450        460        470        480
GPISTTPGII PQKMSLDKYR EKRKLETLDL DVRDHYIAAQ VEQQHKQGQS QAASSSSVTS
       490        500        510        520        530        540
PIKMKIPIAN TEKYMADKKE KSGSLKLRIP IPPTDKSASK EELKMKIKVS SSERHSSSDE
       550        560        570        580        590        600
GSGKSKHSSP HISRDHKEKH KEHPSSRHHT SSHKHSHSHS GSSSGGSKHS ADGIPPTVLR
       610        620        630        640        650        660
SPVGLSSDGI SSSSSSSRKR LHVNDASHNH HSKMSKSSKS SGSSSSSSSS VKQYISSHNS
       670        680        690        700        710        720
VFNHPLPPPP PVTYQVGYGH LSTLVKLDKK PVETNGPDAN HEYSTSSQHM DYKDTFDMLD
       730
SLLSAQGMNM

Isoforms

- Isoform 2 of Cyclin-T2

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O60583-1-unknown	MASGRG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60583-1-unknown	MASGRG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt69794
O60583-455-unknown	HYIAAQ...	455		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O60583-455-unknown	HYIAAQ...	455	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161347
O60583-455-	HYIAAQ...	455		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O60583-455-	HYIAAQ...	455		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O60583-455-	HYIAAQ...	455		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60583-455-	HYIAAQ...	455		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
O60583-606-unknown	SSDGIS...	606	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13771
O60583-606-unknown	SSDGIS...	606	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154665

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SPVGLS	605	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13771
...SPVGLS	605	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138090
...QGMNM	730	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	605	VGLS.\|.SSDG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)