O60664: Perilipin-3

General Information

Protein names	- Perilipin-3 - 47 kDa mannose 6-phosphate receptor-binding protein - 47 kDa MPR-binding protein - Cargo selection protein TIP47 - Mannose-6-phosphate receptor-binding protein 1 - Placental protein 17 - PP17
Gene names	PLIN3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60664

24 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Perilipin-3 - Isoform 3 of Perilipin-3 - Isoform 4 of Perilipin-3

Sequence View

        10         20         30         40         50         60
MSADGAEADG STQVTVEEPV QQPSVVDRVA SMPLISSTCD MVSAAYASTK ESYPHIKTVC
        70         80         90        100        110        120
DAAEKGVRTL TAAAVSGAQP ILSKLEPQIA SASEYAHRGL DKLEENLPIL QQPTEKVLAD
       130        140        150        160        170        180
TKELVSSKVS GAQEMVSSAK DTVATQLSEA VDATRGAVQS GVDKTKSVVT GGVQSVMGSR
       190        200        210        220        230        240
LGQMVLSGVD TVLGKSEEWA DNHLPLTDAE LARIATSLDG FDVASVQQQR QEQSYFVRLG
       250        260        270        280        290        300
SLSERLRQHA YEHSLGKLRA TKQRAQEALL QLSQVLSLME TVKQGVDQKL VEGQEKLHQM
       310        320        330        340        350        360
WLSWNQKQLQ GPEKEPPKPE QVESRALTMF RDIAQQLQAT CTSLGSSIQG LPTNVKDQVQ
       370        380        390        400        410        420
QARRQVEDLQ ATFSSIHSFQ DLSSSILAQS RERVASAREA LDHMVEYVAQ NTPVTWLVGP
       430
FAPGITEKAP EEKK         10         20         30         40         50         60
MSADGAEADG STQVTVEEPV QQPSVVDRVA SMPLISSTCD MVSAAYASTK ESYPHIKTVC
        70         80         90        100        110        120
DAAEKGVRTL TAAAVSGAQP ILSKLEPQIA SASEYAHRGL DKLEENLPIL QQPTEKVLAD
       130        140        150        160        170        180
TKELVSSKVS GAQEMVSSAK DTVATQLSEA VDATRGAVQS GVDKTKSVVT GGVQSVMGSR
       190        200        210        220        230        240
LGQMVLSGVD TVLGKSEEWA DNHLPLTDAE LARIATSLDG FDVASVQQQR QEQSYFVRLG
       250        260        270        280        290        300
SLSERLRQHA YEHSLGKLRA TKQRAQEALL QLSQVLSLME TVKQGVDQKL VEGQEKLHQM
       310        320        330        340        350        360
WLSWNQKQLQ GPEKEPPKPE QVESRALTMF RDIAQQLQAT CTSLGSSIQG LPTNVKDQVQ
       370        380        390        400        410        420
QARRQVEDLQ ATFSSIHSFQ DLSSSILAQS RERVASAREA LDHMVEYVAQ NTPVTWLVGP
       430
FAPGITEKAP EEKK         10         20         30         40         50         60
MSADGAEADG STQVTVEEPV QQPSVVDRVA SMPLISSTCD MVSAAYASTK ESYPHIKTVC
        70         80         90        100        110        120
DAAEKGVRTL TAAAVSGAQP ILSKLEPQIA SASEYAHRGL DKLEENLPIL QQPTEKVLAD
       130        140        150        160        170        180
TKELVSSKVS GAQEMVSSAK DTVATQLSEA VDATRGAVQS GVDKTKSVVT GGVQSVMGSR
       190        200        210        220        230        240
LGQMVLSGVD TVLGKSEEWA DNHLPLTDAE LARIATSLDG FDVASVQQQR QEQSYFVRLG
       250        260        270        280        290        300
SLSERLRQHA YEHSLGKLRA TKQRAQEALL QLSQVLSLME TVKQGVDQKL VEGQEKLHQM
       310        320        330        340        350        360
WLSWNQKQLQ GPEKEPPKPE QVESRALTMF RDIAQQLQAT CTSLGSSIQG LPTNVKDQVQ
       370        380        390        400        410        420
QARRQVEDLQ ATFSSIHSFQ DLSSSILAQS RERVASAREA LDHMVEYVAQ NTPVTWLVGP
       430
FAPGITEKAP EEKK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

24 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O60664-2-unknown	MSADGA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60664-1-unknown	MSADGA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85569
O60664-1-unknown	MSADGA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85570
O60664-2-Acetylation	SADGAE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60664-2-Acetylation	SADGAE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O60664-2-Acetylation	SADGAE...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O60664-2-Acetylation	SADGAE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O60664-2-Acetylation	SADGAE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110560
O60664-2-Acetylation	SADGAE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110561
O60664-10-unknown	GSTQVT...	10		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1114
O60664-10-unknown	GSTQVT...	10			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O60664-10-unknown	GSTQVT...	10		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161772
O60664-10-unknown	GSTQVT...	10		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161773
O60664-10-	GSTQVT...	10			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O60664-10-	GSTQVT...	10			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O60664-10-	GSTQVT...	10			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O60664-10-	GSTQVT...	10			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
O60664-10-	GSTQVT...	10			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60664-10-	GSTQVT...	10			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O60664-10-	GSTQVT...	10			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O60664-41-unknown	MVSAAY...	41		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176552
O60664-41-unknown	MVSAAY...	41		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176553
O60664-41-	MVSAAY...	41			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O60664-44-	AAYAST...	44			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60664-44-unknown	AAYAST...	44		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170757
O60664-44-unknown	AAYAST...	44		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170758
O60664-71-	TAAAVS...	71			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O60664-71-unknown	TAAAVS...	71		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165915
O60664-71-unknown	TAAAVS...	71		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165916
O60664-72-	AAAVSG...	72			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60664-72-unknown	AAAVSG...	72		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172597
O60664-72-unknown	AAAVSG...	72		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172598
O60664-73-	AAVSGA...	73			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O60664-73-unknown	AAVSGA...	73		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167046
O60664-73-unknown	AAVSGA...	73		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167047
O60664-117-	VLADTK...	117			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O60664-117-unknown	VLADTK...	117		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164375
O60664-138-	SAKDTV...	138			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O60664-138-	SAKDTV...	138			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O60664-138-unknown	SAKDTV...	138		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167049
O60664-138-unknown	SAKDTV...	138		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167050
O60664-184-unknown	MVLSGV...	184		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85568
O60664-184-unknown	MVLSGV...	184		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt99441
O60664-184-unknown	MVLSGV...	184		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt99442
O60664-220-	GFDVAS...	220			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O60664-220-	GFDVAS...	220			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O60664-220-	GFDVAS...	220			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O60664-220-	GFDVAS...	220			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O60664-220-	GFDVAS...	220			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60664-220-	GFDVAS...	220			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O60664-220-	GFDVAS...	220			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O60664-220-	GFDVAS...	220			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O60664-220-	GFDVAS...	220			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
O60664-220-	GFDVAS...	220			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O60664-220-unknown	GFDVAS...	220			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O60664-220-unknown	GFDVAS...	220		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161771
O60664-220-unknown	GFDVAS...	220		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161769
O60664-220-unknown	GFDVAS...	220		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161770
O60664-225-unknown	SVQQQR...	225		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176769
O60664-225-unknown	SVQQQR...	225		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176767
O60664-225-unknown	SVQQQR...	225		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176768
O60664-225-	SVQQQR...	225			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O60664-225-	SVQQQR...	225			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GAEADG	9	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1114
...PEEKK	434	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PEEKK	434	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81186
...PEEKK	434	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81188
...PEEKK	434	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81187

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	9	EADG.\|.GSTQ	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)