O75150: E3 ubiquitin-protein ligase BRE1B

General Information

Protein names	- E3 ubiquitin-protein ligase BRE1B - BRE1-B - 2.3.2.27 {ECO:0000269\|PubMed:16307923, ECO:0000269\|PubMed:19410543} - 95 kDa retinoblastoma-associated protein - RBP95 - RING finger protein 40 - RING-type E3 ubiquitin transferase BRE1B {ECO:0000305}
Gene names	RNF40
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75150

6 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSGPGNKRAA GDGGSGPPEK KLSREEKTTT TLIEPIRLGG ISSTEEMDLK VLQFKNKKLA
        70         80         90        100        110        120
ERLEQRQACE DELRERIEKL EKRQATDDAT LLIVNRYWAQ LDETVEALLR CHESQGELSS
       130        140        150        160        170        180
APEAPGTQEG PTCDGTPLPE PGTSELRDPL LMQLRPPLSE PALAFVVALG ASSSEEVELE
       190        200        210        220        230        240
LQGRMEFSKA AVSRVVEASD RLQRRVEELC QRVYSRGDSE PLSEAAQAHT RELGRENRRL
       250        260        270        280        290        300
QDLATQLQEK HHRISLEYSE LQDKVTSAET KVLEMETTVE DLQWDIEKLR KREQKLNKHL
       310        320        330        340        350        360
AEALEQLNSG YYVSGSSSGF QGGQITLSMQ KFEMLNAELE ENQELANSRM AELEKLQAEL
       370        380        390        400        410        420
QGAVRTNERL KVALRSLPEE VVRETGEYRM LQAQFSLLYN ESLQVKTQLD EARGLLLATK
       430        440        450        460        470        480
NSHLRHIEHM ESDELGLQKK LRTEVIQLED TLAQVRKEYE MLRIEFEQNL AANEQAGPIN
       490        500        510        520        530        540
REMRHLISSL QNHNHQLKGD AQRYKRKLRE VQAEIGKLRA QASGSAHSTP NLGHPEDSGV
       550        560        570        580        590        600
SAPAPGKEEG GPGPVSTPDN RKEMAPVPGT TTTTTSVKKE ELVPSEEDFQ GITPGAQGPS
       610        620        630        640        650        660
SRGREPEARP KRELREREGP SLGPPPVASA LSRADREKAK VEETKRKESE LLKGLRAELK
       670        680        690        700        710        720
KAQESQKEMK LLLDMYKSAP KEQRDKVQLM AAERKAKAEV DELRSRIREL EERDRRESKK
       730        740        750        760        770        780
IADEDALRRI RQAEEQIEHL QRKLGATKQE EEALLSEMDV TGQAFEDMQE QNGRLLQQLR
       790        800        810        820        830        840
EKDDANFKLM SERIKANQIH KLLREEKDEL GEQVLGLKSQ VDAQLLTVQK LEEKERALQG
       850        860        870        880        890        900
SLGGVEKELT LRSQALELNK RKAVEAAQLA EDLKVQLEHV QTRLREIQPC LAESRAAREK
       910        920        930        940        950        960
ESFNLKRAQE DISRLRRKLE KQRKVEVYAD ADEILQEEIK EYKARLTCPC CNTRKKDAVL
       970        980        990       1000
TKCFHVFCFE CVRGRYEARQ RKCPKCNAAF GAHDFHRIYI S

Isoforms

- Isoform 3 of E3 ubiquitin-protein ligase BRE1B - Isoform 4 of E3 ubiquitin-protein ligase BRE1B - Isoform 3 of E3 ubiquitin-protein ligase BRE1B - Isoform 4 of E3 ubiquitin-protein ligase BRE1B

Sequence View

        10         20         30         40         50         60
MSGPGNKRAA GDGGSGPPEK KLSREEKTTT TLIEPIRLGG ISSTEEMDLK VLQFKNKKLA
        70         80         90        100        110        120
ERLEQRQACE DELRERIEKL EKRQATDDAT LLIVNRYWAQ LDETVEALLR CHESQGELSS
       130        140        150        160        170        180
APEAPGTQEG PTCDGTPLPE PGTSELRDPL LMQLRPPLSE PALAFVVALG ASSSEEVELE
       190        200        210        220        230        240
LQGRMEFSKA AVSRVVEASD RLQRRVEELC QRVYSRGDSE PLSEAAQAHT RELGRENRRL
       250        260        270        280        290        300
QDLATQLQEK HHRISLEYSE LQDKVTSAET KVLEMETTVE DLQWDIEKLR KREQKLNKHL
       310        320        330        340        350        360
AEALEQLNSG YYVSGSSSGF QGGQITLSMQ KFEMLNAELE ENQELANSRM AELEKLQAEL
       370        380        390        400        410        420
QGAVRTNERL KVALRSLPEE VVRETGEYRM LQAQFSLLYN ESLQVKTQLD EARGLLLATK
       430        440        450        460        470        480
NSHLRHIEHM ESDELGLQKK LRTEVIQLED TLAQVRKEYE MLRIEFEQNL AANEQAGPIN
       490        500        510        520        530        540
REMRHLISSL QNHNHQLKGD AQRYKRKLRE VQAEIGKLRA QASGSAHSTP NLGHPEDSGV
       550        560        570        580        590        600
SAPAPGKEEG GPGPVSTPDN RKEMAPVPGT TTTTTSVKKE ELVPSEEDFQ GITPGAQGPS
       610        620        630        640        650        660
SRGREPEARP KRELREREGP SLGPPPVASA LSRADREKAK VEETKRKESE LLKGLRAELK
       670        680        690        700        710        720
KAQESQKEMK LLLDMYKSAP KEQRDKVQLM AAERKAKAEV DELRSRIREL EERDRRESKK
       730        740        750        760        770        780
IADEDALRRI RQAEEQIEHL QRKLGATKQE EEALLSEMDV TGQAFEDMQE QNGRLLQQLR
       790        800        810        820        830        840
EKDDANFKLM SERIKANQIH KLLREEKDEL GEQVLGLKSQ VDAQLLTVQK LEEKERALQG
       850        860        870        880        890        900
SLGGVEKELT LRSQALELNK RKAVEAAQLA EDLKVQLEHV QTRLREIQPC LAESRAAREK
       910        920        930        940        950        960
ESFNLKRAQE DISRLRRKLE KQRKVEVYAD ADEILQEEIK EYKARLTCPC CNTRKKDAVL
       970        980        990       1000
TKCFHVFCFE CVRGRYEARQ RKCPKCNAAF GAHDFHRIYI S         10         20         30         40         50         60
MSGPGNKRAA GDGGSGPPEK KLSREEKTTT TLIEPIRLGG ISSTEEMDLK VLQFKNKKLA
        70         80         90        100        110        120
ERLEQRQACE DELRERIEKL EKRQATDDAT LLIVNRYWAQ LDETVEALLR CHESQGELSS
       130        140        150        160        170        180
APEAPGTQEG PTCDGTPLPE PGTSELRDPL LMQLRPPLSE PALAFVVALG ASSSEEVELE
       190        200        210        220        230        240
LQGRMEFSKA AVSRVVEASD RLQRRVEELC QRVYSRGDSE PLSEAAQAHT RELGRENRRL
       250        260        270        280        290        300
QDLATQLQEK HHRISLEYSE LQDKVTSAET KVLEMETTVE DLQWDIEKLR KREQKLNKHL
       310        320        330        340        350        360
AEALEQLNSG YYVSGSSSGF QGGQITLSMQ KFEMLNAELE ENQELANSRM AELEKLQAEL
       370        380        390        400        410        420
QGAVRTNERL KVALRSLPEE VVRETGEYRM LQAQFSLLYN ESLQVKTQLD EARGLLLATK
       430        440        450        460        470        480
NSHLRHIEHM ESDELGLQKK LRTEVIQLED TLAQVRKEYE MLRIEFEQNL AANEQAGPIN
       490        500        510        520        530        540
REMRHLISSL QNHNHQLKGD AQRYKRKLRE VQAEIGKLRA QASGSAHSTP NLGHPEDSGV
       550        560        570        580        590        600
SAPAPGKEEG GPGPVSTPDN RKEMAPVPGT TTTTTSVKKE ELVPSEEDFQ GITPGAQGPS
       610        620        630        640        650        660
SRGREPEARP KRELREREGP SLGPPPVASA LSRADREKAK VEETKRKESE LLKGLRAELK
       670        680        690        700        710        720
KAQESQKEMK LLLDMYKSAP KEQRDKVQLM AAERKAKAEV DELRSRIREL EERDRRESKK
       730        740        750        760        770        780
IADEDALRRI RQAEEQIEHL QRKLGATKQE EEALLSEMDV TGQAFEDMQE QNGRLLQQLR
       790        800        810        820        830        840
EKDDANFKLM SERIKANQIH KLLREEKDEL GEQVLGLKSQ VDAQLLTVQK LEEKERALQG
       850        860        870        880        890        900
SLGGVEKELT LRSQALELNK RKAVEAAQLA EDLKVQLEHV QTRLREIQPC LAESRAAREK
       910        920        930        940        950        960
ESFNLKRAQE DISRLRRKLE KQRKVEVYAD ADEILQEEIK EYKARLTCPC CNTRKKDAVL
       970        980        990       1000
TKCFHVFCFE CVRGRYEARQ RKCPKCNAAF GAHDFHRIYI S         10         20         30         40         50         60
MSGPGNKRAA GDGGSGPPEK KLSREEKTTT TLIEPIRLGG ISSTEEMDLK VLQFKNKKLA
        70         80         90        100        110        120
ERLEQRQACE DELRERIEKL EKRQATDDAT LLIVNRYWAQ LDETVEALLR CHESQGELSS
       130        140        150        160        170        180
APEAPGTQEG PTCDGTPLPE PGTSELRDPL LMQLRPPLSE PALAFVVALG ASSSEEVELE
       190        200        210        220        230        240
LQGRMEFSKA AVSRVVEASD RLQRRVEELC QRVYSRGDSE PLSEAAQAHT RELGRENRRL
       250        260        270        280        290        300
QDLATQLQEK HHRISLEYSE LQDKVTSAET KVLEMETTVE DLQWDIEKLR KREQKLNKHL
       310        320        330        340        350        360
AEALEQLNSG YYVSGSSSGF QGGQITLSMQ KFEMLNAELE ENQELANSRM AELEKLQAEL
       370        380        390        400        410        420
QGAVRTNERL KVALRSLPEE VVRETGEYRM LQAQFSLLYN ESLQVKTQLD EARGLLLATK
       430        440        450        460        470        480
NSHLRHIEHM ESDELGLQKK LRTEVIQLED TLAQVRKEYE MLRIEFEQNL AANEQAGPIN
       490        500        510        520        530        540
REMRHLISSL QNHNHQLKGD AQRYKRKLRE VQAEIGKLRA QASGSAHSTP NLGHPEDSGV
       550        560        570        580        590        600
SAPAPGKEEG GPGPVSTPDN RKEMAPVPGT TTTTTSVKKE ELVPSEEDFQ GITPGAQGPS
       610        620        630        640        650        660
SRGREPEARP KRELREREGP SLGPPPVASA LSRADREKAK VEETKRKESE LLKGLRAELK
       670        680        690        700        710        720
KAQESQKEMK LLLDMYKSAP KEQRDKVQLM AAERKAKAEV DELRSRIREL EERDRRESKK
       730        740        750        760        770        780
IADEDALRRI RQAEEQIEHL QRKLGATKQE EEALLSEMDV TGQAFEDMQE QNGRLLQQLR
       790        800        810        820        830        840
EKDDANFKLM SERIKANQIH KLLREEKDEL GEQVLGLKSQ VDAQLLTVQK LEEKERALQG
       850        860        870        880        890        900
SLGGVEKELT LRSQALELNK RKAVEAAQLA EDLKVQLEHV QTRLREIQPC LAESRAAREK
       910        920        930        940        950        960
ESFNLKRAQE DISRLRRKLE KQRKVEVYAD ADEILQEEIK EYKARLTCPC CNTRKKDAVL
       970        980        990       1000
TKCFHVFCFE CVRGRYEARQ RKCPKCNAAF GAHDFHRIYI S         10         20         30         40         50         60
MSGPGNKRAA GDGGSGPPEK KLSREEKTTT TLIEPIRLGG ISSTEEMDLK VLQFKNKKLA
        70         80         90        100        110        120
ERLEQRQACE DELRERIEKL EKRQATDDAT LLIVNRYWAQ LDETVEALLR CHESQGELSS
       130        140        150        160        170        180
APEAPGTQEG PTCDGTPLPE PGTSELRDPL LMQLRPPLSE PALAFVVALG ASSSEEVELE
       190        200        210        220        230        240
LQGRMEFSKA AVSRVVEASD RLQRRVEELC QRVYSRGDSE PLSEAAQAHT RELGRENRRL
       250        260        270        280        290        300
QDLATQLQEK HHRISLEYSE LQDKVTSAET KVLEMETTVE DLQWDIEKLR KREQKLNKHL
       310        320        330        340        350        360
AEALEQLNSG YYVSGSSSGF QGGQITLSMQ KFEMLNAELE ENQELANSRM AELEKLQAEL
       370        380        390        400        410        420
QGAVRTNERL KVALRSLPEE VVRETGEYRM LQAQFSLLYN ESLQVKTQLD EARGLLLATK
       430        440        450        460        470        480
NSHLRHIEHM ESDELGLQKK LRTEVIQLED TLAQVRKEYE MLRIEFEQNL AANEQAGPIN
       490        500        510        520        530        540
REMRHLISSL QNHNHQLKGD AQRYKRKLRE VQAEIGKLRA QASGSAHSTP NLGHPEDSGV
       550        560        570        580        590        600
SAPAPGKEEG GPGPVSTPDN RKEMAPVPGT TTTTTSVKKE ELVPSEEDFQ GITPGAQGPS
       610        620        630        640        650        660
SRGREPEARP KRELREREGP SLGPPPVASA LSRADREKAK VEETKRKESE LLKGLRAELK
       670        680        690        700        710        720
KAQESQKEMK LLLDMYKSAP KEQRDKVQLM AAERKAKAEV DELRSRIREL EERDRRESKK
       730        740        750        760        770        780
IADEDALRRI RQAEEQIEHL QRKLGATKQE EEALLSEMDV TGQAFEDMQE QNGRLLQQLR
       790        800        810        820        830        840
EKDDANFKLM SERIKANQIH KLLREEKDEL GEQVLGLKSQ VDAQLLTVQK LEEKERALQG
       850        860        870        880        890        900
SLGGVEKELT LRSQALELNK RKAVEAAQLA EDLKVQLEHV QTRLREIQPC LAESRAAREK
       910        920        930        940        950        960
ESFNLKRAQE DISRLRRKLE KQRKVEVYAD ADEILQEEIK EYKARLTCPC CNTRKKDAVL
       970        980        990       1000
TKCFHVFCFE CVRGRYEARQ RKCPKCNAAF GAHDFHRIYI S

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75150-1-unknown	MSGPGN...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75150-1-unknown	MSGPGN...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68627
O75150-1-unknown	MSGPGN...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68628
O75150-135-unknown	GTPLPE...	135	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176081
O75150-135-unknown	GTPLPE...	135	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176082
O75150-135-	GTPLPE...	135		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O75150-376-unknown	SLPEEV...	376	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174176
O75150-376-	SLPEEV...	376		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O75150-931-unknown	ADEILQ...	931	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10907
O75150-931-unknown	ADEILQ...	931	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156606

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EVYADA	930	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10907
...EVYADA	930	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140091
...RIYIS	1001	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RIYIS	1001	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64246

TopFIND

O75150: E3 ubiquitin-protein ligase BRE1B

General Information

6

N-termini

2

C-termini

1

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates